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Mitochondrion: A Novel Center for Cancer Cell Signaling

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Mitochondria: The Anti- cancer Target for the Third Millennium

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Abstract

Genomic alterations of normal host cells contribute to the development of cancer. Recent cancer research studies have shown that the aggressive growth and metastasis of cancer cells depend on normal host cells such as fibroblasts, endothelial, mesenchymal and immune cells. Balance among this cellular crosstalk determines the natural history of the cancer and its response to therapy. This active tumor-host dynamic mutualism is referred to as a tumor microenvironment, which can be a key target for both cancer prevention and therapy. An important common feature of various host cells and cancer cells is the generation of reactive oxygen species (ROS) that contribute to the effect of the microenvironment. Mitochondria play a central role in the regulation of ROS production and removal. A shift in cell redox status toward an oxidizing condition activates mitochondrial retrograde signaling, a communication pathway from mitochondria to the nucleus that leads to activation of adaptive response or cell death. Thus, in addition to generating ATP, mitochondria, the powerhouse of cells, play an important role in cell signaling in life-and-death conditions.

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Acknowledgments

We thank our colleagues in the field for their excellent publications not cited here due to space limitations. Work on mitochondrial signaling in our lab is supported by NIH grants CA 049797, CA143428, CA139843, RO1CA073599, and T32 ES007266.

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Authors and Affiliations

  1. Graduate Center for Toxicology, University of Kentucky, Lexington, KY, 40536, USA

    Sumitra Miriyala & Aaron K. Holley

  2. Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences, Shreveport, LA, 71103, USA

    Sumitra Miriyala

  3. Graduate Center for Toxicology, Markey Cancer Center, College of Medicine, University of Kentucky, 458 HSRB, 1095 VA Drive, Lexington, KY, 40536-0305, USA

    Daret K. St. Clair

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  1. Sumitra Miriyala
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  2. Aaron K. Holley
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  3. Daret K. St. Clair
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Correspondence to Daret K. St. Clair .

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Editors and Affiliations

  1. School of Medical Science, Griffith University, Southport, Queensland, Australia

    Jiri Neuzil

  2. School of Medicine, National University of Singapore, Singapore, Singapore

    Shazib Pervaiz

  3. Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany

    Simone Fulda

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Miriyala, S., Holley, A.K., Clair, D.K.S. (2014). Mitochondrion: A Novel Center for Cancer Cell Signaling. In: Neuzil, J., Pervaiz, S., Fulda, S. (eds) Mitochondria: The Anti- cancer Target for the Third Millennium. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8984-4_1

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