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Haloperoxidase Enzymes as ‘Redox Catalysts’ Important for Industrial Biocatalysis

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Recent Advances in Redox Active Plant and Microbial Products

Abstract

Many natural compounds are halogenated and the enzymes that carry out these reactions have been characterized. This chapter provides a brief overview of the different types of halogenating enzymes characterized to date and their differing structures. It concentrates specifically on the vanadium haloperoxidases with regard to their structure and mechanism and their uses in industrial biocatalysis. Many new drugs entering the market are halogenated and this modification is known to change their biological activity. The use of the enzymes known to carry out these specific reactions in ‘nature’ is important for the industrial biosynthesis of new drug molecules and halogenated building blocks for the pharmaceutical industry.

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Acknowledgments

The authors acknowledge the support of BBSRC project grants and funding of PhD studentships associated with the vanadium bromoperoxidase project and the support of European Community’s 7th Framework Programme [FP7/2007-2013] under grant agreement No: 215009 (RedCat).

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Authors and Affiliations

  1. Henry Wellcome Building for Biocatalysis, Biosciences, College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter, EX4 4QD, UK

    Jennifer Littlechild & Michail Isupov

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  1. Jennifer Littlechild
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  2. Michail Isupov
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Corresponding author

Correspondence to Jennifer Littlechild .

Editor information

Editors and Affiliations

  1. Bioorganic Chemistry/School of Pharmacy, University of Saarland, Saarbrücken, Saarland, Germany

    Claus Jacob

  2. SRSMC UMR 7565, Université de Lorraine, Metz, Moselle, France

    Gilbert Kirsch

  3. Plant Physiology (Bio III), RWTH Aachen University, Aachen, Germany

    Alan Slusarenko

  4. Medical School, University of Exeter, Exeter, United Kingdom

    Paul G. Winyard

  5. Bioorganic Chemistry/School of Pharmacy, University of Saarland, Saarbrücken, Saarland, Germany

    Torsten Burkholz

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Littlechild, J., Isupov, M. (2014). Haloperoxidase Enzymes as ‘Redox Catalysts’ Important for Industrial Biocatalysis. In: Jacob, C., Kirsch, G., Slusarenko, A., Winyard, P., Burkholz, T. (eds) Recent Advances in Redox Active Plant and Microbial Products. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8953-0_17

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