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Evolution of Biosynthetic Pathways

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Abstract

The main goal of the student of evolution is to reconstruct past events leading to the structure of contemporary proteins, from which the relationships which they share with a common ancestor can be defined. A single sequence can give rise to different sequences by speciation and divergence or by gene duplication within a single organism followed by divergence. We shall see examples of these two cases in our survey of the evolution of biosynthetic pathways.

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Selected References

Two Books

  • Loomis WF (1988) Four billion years, an essay on the evolution of genes and organisms. Sinauer Associates, Sunderland, p 286

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  • Mortlock RP (ed) (1992) The evolution of metabolic function. CRC Press, Boca Raton, p 330

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Two Different Theories on the Evolution of Biosynthetic Pathways

Common Origin of Cystathionine-γ-Synthase and Cystathionase

Common Origin of Threonine Synthase, Threonine Dehydratase, D-Serine Dehydratase, and the B Chain of Tryptophan Synthase

Comparison of Arg Genes with Homologous and Analogous Enzymes

Evolution of the E. coli Aspartokinases and Homoserine Dehydrogenases

Structural and Evolutionary Relationships Between E. coli Aspartokinase-Homoserine Dehydrogenases and Monofunctional Homoserine Dehydrogenases

Superfamily of Transmembrane Facilitators

DNA-Binding Regulator Proteins

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Cohen, G.N. (2014). Evolution of Biosynthetic Pathways. In: Microbial Biochemistry. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8908-0_40

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