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Biosynthesis of the Amino Acids of the Glutamic Acid Family and Its Regulation

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Abstract

This reaction is carried out by an enzyme, glutamine synthetase, whose occurrence is not restricted to microorganisms. It is essential not only for the synthesis of glutamine, a building block of proteins. Glutamine contributes also through its amide group to the synthesis of many nitrogen containing substances; in addition, it is an obligatory intermediate in ammonia assimilation in ammonia-limited media.

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Selected References

Glutamine Synthetase Activity and Its Regulation by Covalent Modification: Structure

Glutamine Synthetase Regulation of Gene Expression

The Levels of Glutamine Synthetase Are Also Regulated by Oxidation Followed by Proteolytic Degradation

Glutamate Synthase

Glutamate Decarboxylase

Proline Biosynthesis

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Polyamine Biosynthesis

The Arginine Repressor

Spermidine Biosynthesis

The Methionine Salvage Pathway

Nitric Oxide Synthase

Aminoadipic Acid Pathway

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Cohen, G.N. (2014). Biosynthesis of the Amino Acids of the Glutamic Acid Family and Its Regulation. In: Microbial Biochemistry. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8908-0_28

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