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Intracellular Delivery II pp 35–53Cite as

Zwitterionic Nanocarriers for Gene Delivery

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Part of the book series: Fundamental Biomedical Technologies ((FBMT,volume 7))

Abstract

“Gene therapy” is studied for its potential in modifying the genetic information of an organism and to treat cancerous, cardiovascular, neurological, and infectious diseases. A key limitation in the current development of human gene therapy is the lack of safe, efficient, and controllable gene delivery methods. Hundreds of clinical trials in human gene therapy have been approved worldwide since the 1980s but is met with only a small number of successes. This review discusses the hurdles and hopes of zwitterionic polybetaines in molecular cargo formulation of multi-functional gene nanocarriers.

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Abbreviations

ADA:

Adenosine deaminase

APE:

Antipolyelectrolyte effect

BCs:

Block copolymers

BMA:

n-Butyl methacrylate

CBMA:

Carboxybetaine methacrylate

CST:

Critical solution temperature

DMAEMA–MPC:

2-(Dimethylamino)ethyl methacrylate-block-2-(methacryloyloxyethyl Phosphorylcholine)

MPC:

Methacryloyloxyethyl phosphorylcholine

MPC-co-LMA2:

2-Methacryloyloxyethyl phosphorylcholine-co-lauryl methacrylat

MPTMS:

3-Methacryloyloxypropyl trimethoxysilane

NIPAAm:

N-isopropylacrylamide

PS:

Phosphatidylserine

PC:

Phosphorylcholine

PAA:

Poly (acrylic acid)

PDMAEMA:

Poly(2-dimethylamino)ethyl methacrylate

PBMA:

Poly(butyl methacrylate)

PCBMA:

Poly(carboxybetaine methacrylate)

PEG:

Poly(ethylene glycol)

PLL:

Poly(L-lysine)

PSD:

Poly(methacryloyl sulfadimethoxine)

PMB:

Poly(MPC-co-BMA)

PHEMA:

Poly(N-(2-hydroxpropyl)methacrylamide)

PPO:

Poly(propylene oxide)

PSBMA:

Poly(sulfobetaine methacrylate)

PEI:

Polyethyleneimine

PZ:

Polyzwitterions

RES:

Reticuloendothelial system

R9:

Nona-arginine peptide

SAMs:

Self-assembled Monolayers

SCID:

Severe combined immunodeficiency

siRNA:

Small interfering RNA

SBMA:

Sulfobetaine methacrylate

SPR:

Surface plasmon resonance

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Authors and Affiliations

  1. R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Chung-Li, Taoyuan, 320, Taiwan

    Yu-Ju Shih, Ching-Wei Tsai, Lemmuel L. Tayo & Yung Chang

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  1. Yu-Ju Shih
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  2. Ching-Wei Tsai
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  3. Lemmuel L. Tayo
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  4. Yung Chang
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Correspondence to Yung Chang .

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Editors and Affiliations

  1. Chemical and Biological Engineering, Vanderbilt University, Nashville, Tennessee, USA

    Aleš Prokop

  2. Chemistry and Materials Engineering, Kansai University, Osaka, Japan

    Yasuhiko Iwasaki

  3. Department of Applied Chemistry, Osaka Prefecture University, Osaka, Japan

    Atsushi Harada

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Shih, YJ., Tsai, CW., Tayo, L.L., Chang, Y. (2014). Zwitterionic Nanocarriers for Gene Delivery. In: Prokop, A., Iwasaki, Y., Harada, A. (eds) Intracellular Delivery II. Fundamental Biomedical Technologies, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8896-0_3

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