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Membrane-Domain-Selective Drug Targeting Based on Lipid Modification

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Intracellular Delivery II

Part of the book series: Fundamental Biomedical Technologies ((FBMT,volume 7))

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Abstract

Cellular lipid bilayers are critical platforms for the myriad of functions performed by membrane proteins. Drugs modified with lipid membrane anchors can selectively target membrane proteins. In this review, we discuss preferences of representative lipidated molecules for specific cellular membrane domains and the recent progress in lipidated drug delivery.

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Abbreviations

ER:

Endoplasmic reticulum

GPI:

Glycosylphosphatidylinositol

PEG:

Polyethylene glycol

CLIC:

Clathrin-independent carrier

GPCR:

G protein-coupled receptor

APP:

Amyloid precursor protein

HIV:

Human immunodeficiency virus

HBV:

Hepatitis B virus

PAR1:

Protease-activated receptor 1

CXCR4:

CXC-type receptor 4

SMO:

Smoothened

IGF1R:

Insulin-like growth factor 1 receptor

STAT3:

Signal transducer and activator of transcription 3

SH2:

Src homology 2

TRPV1:

Transient receptor potential vanilloid 1

PAT:

Palmitoyl acyl transferase

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Author information

Authors and Affiliations

  1. Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan

    Takeshi Mori & Yoshiki Katayama

  2. Center For Future Chemistry, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan

    Takeshi Mori & Yoshiki Katayama

Authors
  1. Takeshi Mori
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  2. Yoshiki Katayama
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Corresponding author

Correspondence to Takeshi Mori .

Editor information

Editors and Affiliations

  1. Chemical and Biological Engineering, Vanderbilt University, Nashville, Tennessee, USA

    Aleš Prokop

  2. Chemistry and Materials Engineering, Kansai University, Osaka, Japan

    Yasuhiko Iwasaki

  3. Department of Applied Chemistry, Osaka Prefecture University, Osaka, Japan

    Atsushi Harada

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Mori, T., Katayama, Y. (2014). Membrane-Domain-Selective Drug Targeting Based on Lipid Modification. In: Prokop, A., Iwasaki, Y., Harada, A. (eds) Intracellular Delivery II. Fundamental Biomedical Technologies, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8896-0_11

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