Abstract
Cancer Stem Cells are defined as group of cells that have the capacity to self-renewal, initiate tumor growth and metastatic potential. Gastric Cancer stem cell (GCSC) investigations are part of the expanding research field of cancer stem-cell biology of a wide variety of organs. New evidence of several years of investigation, indicate the existence of cancer stem cell. Several data suggest that a subpopulation with a defined marker show spheroid colony formation in serum-free media in vitro, as well as tumorigenic ability immunodeficient mice in vivo. There are information about possible origins of gastric cancer stem cell form an organ-specific stem cell versus a recently recognized new candidate bone marrow-derived cell (BMDC), related to malignant epithelial cells in the mouse model of Helicobacter associated gastric cancer. Bone marrow stem cells has provided enough information to explain stem cell cancer model and has open a wide field in treatment research developing a wide variety of treatment such targeted therapies and bone marrow transplantation in hematologic malignances. Using similar models, interesting evidence have been discovered in solid tumors like colon cancer, pancreatic cancer, although evidence in GCSC is inconsistent, further studies focusing on characterization and identification of GCSC biology may lead to novel strategies in diagnostics and therapeutics that could change the prognosis of gastric cancer patients.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Siegel R, Naishadham D, Jemal A (2012) Cancer statistics, 2012. CA Cancer J Clin 62:10–29
Kamangar F, Dores GM, Anderson WF (2006) Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 24:2137–2150
Gupta PB, Chaffer CL, Weinberg RA (2009) Cancer stem cells: mirage or reality? Nat Med 15(9):1010–1012
Camargo MC, Anderson WF, King JB, Correa P, Thomas CC, Rosenberg PS, Eheman CR, Rabkin CS (2011) Divergent trends for gastric cancer incidence by anatomical subsite in US adults. Gut 60:1644–1649
Wu H, Rusiecki JA, Zhu K, Potter J, Devesa SS (2009) Stomach carcinoma incidence patterns in the United States by histologic type and anatomic site. Cancer Epidemiol Biomarkers Prev 18:1945–1952
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127:2893–2917
Yang P, Zhou Y, Chen B, Wan HW, Jia GQ, Bai HL, Wu XT (2009) Overweight, obesity and gastric cancer risk: results from a meta-analysis of cohort studies. Eur J Cancer 45:2867–2873
Alberts SR, Cervantes A, van de Velde CJ (2003) Gastric cancer: epidemiology, pathology and treatment. Ann Oncol 14(Suppl 2):ii31–ii36
Machida-Montani A, Sasazuki S, Inoue M, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Hanaoka T, Tsugane S (2004) Association of Helicobacter pylori infection and environmental factors in non-cardia gastric cancer in Japan. Gastric Cancer 7:46–53
Fox JG, Wang TC (2007) Inflammation, atrophy, and gastric cancer. J Clin Invest 117:60–69
Lauren P (1965) The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 64:31–49
Correa P, Shiao YH (1994) Phenotypic and genotypic events in gastric carcinogenesis. Cancer Res 54:1941s–1943s
Correa P (1995) Helicobacter pylori and gastric carcinogenesis. Am J Surg Pathol 19(Suppl 1):S37–S43
Takaishi S, Okumura T, Tu S, Wang SS, Shibata W, Vigneshwaran R, Gordon SA, Shimada Y, Wang TC (2009) Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells 27(5):1006–1020
Zhang C, Li C, He F, Cai Y, Yang H (2011) Identification of CD44 + CD24+ gastric cancer stem cells. J Cancer Res Clin Oncol 137(11):1679–1686
Takaishi S, Okumura T, Wang TC (2008) Gastric cancer stem cells. J Clin Oncol 26:2876–2882
Houghton J, Morozov A, Smirnova I et al (2007) Stem cells and cancer. Semin Cancer Biol 17:191–203
Lapidot T, Sirard C, Vormoor J et al (1994) A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367:645–648
Vermeulen L, Sprick MR, Kemper K et al (2008) Cancer stem cells—old concepts, new insights. Cell Death Differ 15:947–958
Houghton J, Stoicov C, Nomura S et al (2004) Gastric cancer originating from bone marrow-derived cells. Science 306:1568–1571
Houghton J, Wang TC (2005) Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers. Gastroenterology 128:1567–1578
Woodward WA, Sulman EP (2008) Cancer stem cells: markers or biomarkers? Cancer Metastasis Rev 27(3):459–470
Ferrandina G, Petrillo M, Bonanno G, Scambia G (2009) Targeting CD133 antigen in cancer. Expert Opin Ther Targets 13(7):823–837
Rocco A, Liguori E, Pirozzi G, Tirino V, Compare D, Franco R et al (2012) CD133 and CD44 cell surface markers do not identify cancer stem cells in primary human gastric tumors. J Cell Physiol 227(6):2686–2693
Quante M, Wang TC (2009) Stem cells in gastroenterology and hepatology. Nat Rev Gastroenterol Hepatol 6(12):724–737
Ding SZ, Zheng PY (2012) Helicobacter pylori infection induced gastric cancer; advance in gastric stem cell research and the remaining challenges. Gut Pathog 4(1):18
Dewi DL, Ishii H, Kano Y, Nishikawa S, Haraguchi N, Sakai D, Satoh T, Doki Y, Mori M (2011) Cancer stem cell theory in gastrointestinal malignancies: recent progress and upcoming challenges. J Gastroenterol 46(10):1145–1157
Gomceli I, Demiriz B, Tez M (2012) Gastric carcinogenesis. World J Gastroenterol 18(37):5164–5170
Hoffmann W (2012) Stem cells, self-renewal and cancer of the gastric epithelium. Curr Med Chem 19(35):5975–5983
Nishimura K, Semba S, Aoyagi K, Sasaki H, Yokozaki H (2012) Mesenchymal stem cells provide an advantageous tumor microenvironment for the restoration of cancer stem cells. Pathobiology 79(6):290–306
Worthley DL, Ruszkiewicz A, Davies R, Moore S, Nivison-Smith I, Bik To L, Browett P, Western R, Durrant S, So J et al (2009) Human gastrointestinal neoplasia-associated myofibroblasts can develop from bone marrow-derived cells following allogeneic stem cell transplantation. Stem Cells 27:1463–1468
Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson J, Li H, Cai X, Fox JG, Goldenring JR, Wang TC (2004) Gastric cancer originating from bone marrow-derived cells. Science 306:1568–1571
Cuiffo BG, Karnoub AE (2012) Mesenchymal stem cells in tumor development: emerging roles and concepts. Cell Adh Migr 6(3):220–230
Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM (2006) Cancer stem cells–perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 66:9339–9344
Sell S (2004) Stem cell origin of cancer and differentiation therapy. Crit Rev Oncol Hematol 51:1–28
Saikawa Y, Fukuda K, Takahashi T, Nakamura R, Takeuchi H, Kitagawa Y (2010) Gastric carcinogenesis and the cancer stem cell hypothesis. Gastric Cancer 13(1):11–24
Shaker A, Rubin DC (2010) Intestinal stem cells and epithelial-mesenchymal interactions in the crypt and stem cell niche. Transl Res 156(3):180–187
Yang YC, Wang SW, Hung HY, Chang CC, Wu IC, Huang YL, Lin TM, Tsai JL, Chen A, Kuo FC, Wang WM, Wu DC (2007) Isolation and characterization of human gastric cell lines with stem cell phenotypes. J Gastroenterol Hepatol 22(9):1460–1468
Bellini MF, Cadamuro AC, Succi M, Proença MA, Silva AE (2012) Alterations of the TP53 gene in gastric and esophageal carcinogenesis. J Biomed Biotechnol 2012:891961
Kuhn NZ, Tuan RS (2010) Regulation of stemness and stem cell niche of mesenchymal stem cells: implications in tumorigenesis and metastasis. J Cell Physiol 222(2):268–277
Goldenring JR, Nam KT, Mills JC (2011) The origin of pre-neoplastic metaplasia in the stomach: chief cells emerge from the Mist. Exp Cell Res 317(19):2759–2764
Hoffmann W (2013) Self-renewal of the gastric epithelium from stem and progenitor cells. Front Biosci (Schol Ed) 5:720–731
Karam SM (2008) Cellular origin of gastric cancer. Ann N Y Acad Sci 1138:162–168. doi:10.1196/annals.1414.023
Qiao XT, Gumucio DL (2011) Current molecular markers for gastric progenitor cells and gastric cancer stem cells. J Gastroenterol 46(7):855–865. doi:10.1007/s00535-011-0413-y. Epub 2011 Jun 1
Han ME, Jeon TY, Hwang SH, Lee YS, Kim HJ, Shim HE, Yoon S, Baek SY, Kim BS, Kang CD, Oh SO (2011) Cancer spheres from gastric cancer patients provide an ideal model system for cancer stem cell research. Cell Mol Life Sci 68(21):3589–3605
Saikawa Y, Fukuda K, Takahashi T, Nakamura R, Takeuchi H, Kitagawa Y (2010) Gastric carcinogenesis and the cancer stem cell hypothesis. Gastric Cancer 13(1):11–24
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Rangel, J.D.G. (2014). Cancer Stem Cells in Gastric Cancer. In: Grande, E., Antón Aparicio, L. (eds) Stem Cells in Cancer: Should We Believe or Not?. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8754-3_9
Download citation
DOI: https://doi.org/10.1007/978-94-017-8754-3_9
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-017-8753-6
Online ISBN: 978-94-017-8754-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)