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Paeonia lactiflora

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Selected References

  • Aimi N, Inaba M, Watanabe M, Shibata S (1969) Chemical studies on the oriental plant drugs—XXIII Paeoniflorin, a glucoside of Chinese paeony root. Tetrahedron 25(9):1825–1839

    Article  PubMed  CAS  Google Scholar 

  • Asai M, Kawashima D, Katagiri K, Takeuchi R, Tohnai G, Ohtsuka K (2011) Protective effect of a molecular chaperone inducer, paeoniflorin, on the HCl- and ethanol-triggered gastric mucosal injury. Life Sci 88(7–8):350–357

    Article  PubMed  CAS  Google Scholar 

  • Bao T, Yang Q, Zhang Y, Dong Y, Li Y, Zhu X (2010) Pharmacokinetics study on paeoniflorin in radix paeoniae alba extract by LC-MS. Zhongguo Zhong Yao Za Zhi 35(9):1193–1196 (in Chinese)

    PubMed  CAS  Google Scholar 

  • Baumgartner RR, Steinmann D, Heiss EH, Atanasov AG, Ganzera M, Stuppner H, Dirsch VM (2010) Bioactivity-guided isolation of 1,2,3,4,6-penta-O-galloyl-d-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor. J Nat Prod 73(9):1578–1581

    Article  PubMed  CAS  Google Scholar 

  • Boo KH, Lee DS, Woo JK, Ko SH, Jeong EH, Hong QC, Riu KZ, Lee DS (2011) Anti-bacterial and anti-viral activity of extracts from Paeonia lactiflora roots. J Korean Soc Appl Biol Chem 54(1):132–135

    Article  Google Scholar 

  • Bown D (1995) Encyclopaedia of herbs and their uses. Dorling Kindersley, London, 424 pp

    Google Scholar 

  • Braca A, Kiem PV, Yen PH, Nhiem NX, Quang TH, Cuong NX, Minh CV (2008) New monoterpene glycosides from Paeonia lactiflora. Fitoterapia 79(2):117–120

    Article  PubMed  CAS  Google Scholar 

  • Cao BY, Yang YP, Luo WF, Mao CJ, Han R, Sun X, Cheng J, Liu CF (2010) Paeoniflorin, a potent natural compound, protects PC12 cells from MPP + and acidic damage via autophagic pathway. J Ethnopharmacol 131(1):122–129

    Article  PubMed  CAS  Google Scholar 

  • Chan K, Liu ZQ, Jiang ZH, Zhou H, Wong YF, Xu HX, Liu L (2006) The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model. J Ethnopharmacol 103(3):425–432

    Article  PubMed  CAS  Google Scholar 

  • Chang Y, Wei W, Zhang L, Xu HM (2009) Effects and mechanisms of total glucosides of paeony on synoviocytes activities in rat collagen-induced arthritis. J Ethnopharmacol 121(1):43–48

    Article  PubMed  CAS  Google Scholar 

  • Chang Y, Zhang L, Wang C, Jia XY, Wei W (2011) Paeoniflorin inhibits function of synoviocytes pretreated by rIL-1α and regulates EP4 receptor expression. J Ethnopharmacol 137(3):1275–1282

    Article  PubMed  CAS  Google Scholar 

  • Chang KH, Chen WL, Lee LC, Lin CH, Kung PJ, Lin TH, Wu YC, Wu YR, Chen YC, Lee-Chen GJ, Chen CM (2013) Aqueous extract of Paeonia lactiflora and paeoniflorin as aggregation reducers targeting chaperones in cell models of spinocerebellar ataxia 3. Evid Based Complement Alternat Med 2013:471659

    PubMed Central  PubMed  Google Scholar 

  • Chen G, Zhang L, Yang P (2005) Rapid determination of paeoniflorin and three sugars in Radix Paeoniae Alba by capillary electrophoresis. Anal Sci 21(3):247–251

    Article  PubMed  Google Scholar 

  • Chen G, Deng XH, Guo LX, Liu JH (2008) Effect of total glucosides of paeony on nuclear factor-kappaB activation in rat peritoneal macrophages. Zhongguo Zhong Yao Za Zhi 33(6):669–671

    PubMed  Google Scholar 

  • Chen T, Guo ZP, Jiao XY, Jia RZ, Zhang YH, Li JY, Huang XL, Liu HJ (2011a) Peoniflorin suppresses tumor necrosis factor-α induced chemokine production in human dermal microvascular endothelial cells by blocking nuclear factor-κB and ERK pathway. Arch Dermatol Res 303(5):351–360

    Article  PubMed  CAS  Google Scholar 

  • Chen T, Guo ZP, Jiao XY, Zhang YH, Li JY, Liu HJ (2011b) Protective effects of peoniflorin against hydrogen peroxide-induced oxidative stress in human umbilical vein endothelial cells. Can J Physiol Pharmacol 89(6):445–453

    Article  PubMed  CAS  Google Scholar 

  • Chen JY, Wu HX, Chen Y, Zhang LL, Wang QT, Sun WY, Wei W (2012a) Paeoniflorin inhibits proliferation of fibroblast-like synoviocytes through suppressing G-protein-coupled receptor kinase 2. Planta Med 78(7):665–671

    Article  PubMed  CAS  Google Scholar 

  • Chen Y, Zhou L, Xin R, Wang J, Jia X (2012b) Multi-channel analysis and comparison on absorption difference between paeoniflorin and Paeonia lactiflora extracts. Zhongguo Zhong Yao Za Zhi 37(13):2012–2016 (in Chinese)

    PubMed  CAS  Google Scholar 

  • Chen T, Guo ZP, Wang L, Qin S, Cao N, Li MM, Jia RZ, Wang TT (2013a) Paeoniflorin suppresses vascular damage and the expression of E-selectin and ICAM-1 in a mouse model of cutaneous Arthus reaction. Exp Dermatol 22(7):453–457

    Article  PubMed  CAS  Google Scholar 

  • Chen YF, Wu KJ, Wood WG (2013b) Paeonia lactiflora extract attenuating cerebral ischemia and arterial intimal hyperplasia is mediated by paeoniflorin via modulation of VSMC migration and Ras/MEK/ERK signaling pathway. Evid Based Complement Alternat Med 2013:482428

    PubMed Central  PubMed  Google Scholar 

  • Chen Z, Li XP, Li ZJ, Xu L, Li XM (2013c) Reduced hepatotoxicity by total glucosides of paeony in combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis. Int Immunopharmacol 15(3):474–477

    Article  PubMed  CAS  Google Scholar 

  • Cheng JT, Wang CJ, Hsu FL (1999) Paeoniflorin reverses guanethidine-induced hypotension via activation of central adenosine A1 receptors in Wistar rats. Clin Exp Pharmacol Physiol 26(10):815–816

    Article  PubMed  CAS  Google Scholar 

  • Cheng Y, Peng C, Wen F, Zhang H (2010) Pharmacokinetic comparisons of typical constituents in white peony root and sulfur fumigated white peony root after oral administration to mice. J Ethnopharmacol 129(2):167–173

    Article  PubMed  CAS  Google Scholar 

  • Chevallier A (1996) The encyclopedia of medicinal plants. Dorling Kindersley, London, 336 pp

    Google Scholar 

  • Chimielewska L, Kasprzyk Z (1962) Pyrethrin and gallotannin in the flowers of peony. Nature 196:776

    Article  Google Scholar 

  • Choi EM, Lee YS (2013) Paeoniflorin isolated from Paeonia lactiflora attenuates osteoblast cytotoxicity induced by antimycin A. Food Funct 4(9):1332–1338

    Article  PubMed  CAS  Google Scholar 

  • Choi CW, Choi YH, Cha MR, Park JH, Kim YS, Kim YK, Choi SU, Yon GH, Hong KS, Kim YH, Ryu SY (2009) α-Glucosidase inhibitors from seed extract of Paeonia lactiflora. J Korean Soc Appl Biol Chem 52(6):638–642

    Article  CAS  Google Scholar 

  • Choi CW, Choi YH, Cha MR, Kim YS, Yon GH, Hong KS, Park WK, Kim YH, Ryu SY (2011) In vitro BACE-1 inhibitory activity of resveratrol oligomers from the seed extract of Paeonia lactiflora. Planta Med 77(4):374–376

    Article  PubMed  CAS  Google Scholar 

  • Choung MG, Kang KH, An YN (2000) Isolation and determination of phenolic compounds in peony (Paeonia lactiflora Pall.) root. Korean J Crop Sci 45(2):83–87

    Google Scholar 

  • Chuang WC, Lin WC, Sheu SJ, Chiou SH, Chang HC, Chen YP (1996) A comparative study on commercial samples of the roots of Paeonia vitchii and P. lactiflora. Planta Med 62(4):347–351

    Article  PubMed  CAS  Google Scholar 

  • Deane G (2007–2012) Edible flowers: part seven. http://www.eattheweeds.com/edible-flowers-part-seven/

  • Deng H, Yan C, Xiao T, Yuan D, Xu J (2010) Total glucosides of Paeonia lactiflora Pall inhibit vascular endothelial growth factor-induced angiogenesis. J Ethnopharmacol 127(3):781–785

    Article  PubMed  CAS  Google Scholar 

  • Du JH, Dong BD (2005) Comparative study on clinical efficacy of using methotrexate singly or combined with total glucosides of paeony in treating rheumatoid arthritis. Zhongguo Zhong Xi Yi Jie He Za Zhi 25(6):540–542 (in Chinese)

    PubMed  Google Scholar 

  • Duan WJ, Jiang Y, Jin X, Qin GY, Qiu F (2009a) Chemical constituents of Paeonia albiflora. Zhongguo Yao Wu Hua Xue Za Zhi (Chin J Med Chem) 19(1):55–58

    CAS  Google Scholar 

  • Duan WJ, Jin X, Chen LX, Zhang X, Yao XS, Qiu F (2009b) Four new compounds from Paeonia albiflora. J Asian Nat Prod Res 11(4):299–305

    Article  PubMed  CAS  Google Scholar 

  • Duan WJ, Yang JY, Chen LX, Zhang LJ, Jiang ZH, Cai XD, Zhang X, Qiu F (2009c) Monoterpenes from Paeonia albiflora and their inhibitory activity on nitric oxide production by lipopolysaccharide-activated microglia. J Nat Prod 72(9):1579–1584

    Article  PubMed  CAS  Google Scholar 

  • Duke JA, Ayensu ES (1985) Medicinal plants of China, vols. 1 and 2. Reference Publications, Inc. Algonac, 705 pp

    Google Scholar 

  • Egger K (1961) Aus gefUllten bliiten von Paeonia albiflora. L. var. hortensis (Paeoniaceae). Z Naturf 16b:430–431

    Google Scholar 

  • Facciola S (1990) Cornucopia. A source book of edible plants. Kampong Publ., Vista, 677 pp

    Google Scholar 

  • Fan YF, Xie Y, Liu L, Ho HM, Wong YF, Liu ZQ, Zhou H (2012) Paeoniflorin reduced acute toxicity of aconitine in rats is associated with the pharmacokinetic alteration of aconitine. J Ethnopharmacol 141(2):701–708

    Article  PubMed  CAS  Google Scholar 

  • Fu Q, Wang SB, Zhao SH, Chen XJ, Tu PF (2013) Three new monoterpene glycosides from the roots of Paeonia lactiflora. J Asian Nat Prod Res 15(7):697–702

    Article  PubMed  CAS  Google Scholar 

  • Gao XH, Xu XX, Pan R, Wang C, Sheng R, Xia YF, Dai Y (2011) Qi-Shao-Shuang-Gan, a combination of Astragalus membranaceus saponins with Paeonia lactiflora glycosides, ameliorates polymicrobial sepsis induced by cecal ligation and puncture in mice. Inflammation 34(1):10–21

    Article  PubMed  CAS  Google Scholar 

  • Goto H, Shimada Y, Akechi Y, Kohta K, Hattori M, Terasawa K (1996) Endothelium-dependent vasodilator effect of extract prepared from the roots of Paeonia lactiflora on isolated rat aorta. Planta Med 62(5):436–439

    Article  PubMed  CAS  Google Scholar 

  • Goto H, Shimada Y, Tanaka N, Tanigawa K, Itoh T, Terasawa K (1999) Effect of extract prepared from the roots of Paeonia lactiflora on endothelium-dependent relaxation and antioxidant enzyme activity in rats administered high-fat diet. Phytother Res 13(6):526–528

    Article  PubMed  CAS  Google Scholar 

  • Grieve M (1971) A modern herbal, 2 vols. Penguin, London; Dover Publications, New York, 919 pp

    Google Scholar 

  • Guo D, Ye G, Guo H (2006) A new phenolic glycoside from Paeonia lactiflora. Fitoterapia 77(7–8):613–614

    Article  PubMed  CAS  Google Scholar 

  • Hattori M, Shu YZ, Shimizu M, Hayashi T, Morita N, Kobashi K, Xu GJ, Namba T (1985) Metabolism of paeoniflorin and related compounds by human intestinal bacteria. Chem Pharm Bull 33(9):3838–3846

    Article  PubMed  CAS  Google Scholar 

  • Hayashi T, Shinbo T, Shimizu M, Arisawa M, Morita N, Kimura M, Matsuda S, Kikuchi T (1985) Paeonilactones A, B and C new monoterpenoids from peony Paeonia albiflora var trichocarpa root. Tetrahedron Lett 26:3699–3702

    Article  CAS  Google Scholar 

  • He DY, Dai SM (2011) Anti-inflammatory and immunomodulatory effects of Paeonia lactiflora Pall., a traditional Chinese herbal medicine. Front Pharmacol 2:10

    Article  PubMed Central  PubMed  Google Scholar 

  • He XH, Xing DM, Ding Y, Li YP, Xu LZ, Du LJ (2004) Effects of cerebral ischemia-reperfusion on pharmacokinetic fate of paeoniflorin after intravenous administration of Paeoniae Radix extract in rats. J Ethnopharmacol 94(2–3):339–344

    Article  PubMed  CAS  Google Scholar 

  • He XY, Han L, Huang XS (2011) A new phenolic glucoside from Paeonia lactiflora. China Herb Med 3(2):84–86

    CAS  Google Scholar 

  • Hedrick UP (1972) Sturtevant’s edible plants of the world. Dover Publications, New York, 686 pp

    Google Scholar 

  • Heikal OA, Akao T, Takeda S, Hattori M (1997) Pharmacokinetic study of paeonimetabolin I, a major metabolite of paeoniflorin from paeony roots. Biol Pharm Bull 20(5):517–521

    Article  PubMed  CAS  Google Scholar 

  • Hong DY, Pan KY, Turland NJ (2001) Paeoniaceae. In: Wu ZY, Raven PH, Hong DY (eds) Flora of China, vol 6, Caryophyllaceae through Lardizabalaceae. Science Press/Missouri Botanical Garden Press, Beijing/St. Louis

    Google Scholar 

  • Hsieh CL, Cheng CY, Tsai TH, Lin IH, Liu CH, Chiang SY, Lin JG, Lao CJ, Tang NY (2006) Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. J Ethnopharmacol 106(2):208–215

    Article  PubMed  CAS  Google Scholar 

  • Hsiu SL, Lin YT, Wen KC, Hou YC, Chao PD (2003) A deglucosylated metabolite of paeoniflorin of the root of Paeonia lactiflora and its pharmacokinetics in rats. Planta Med 69(12):1113–1118

    Article  PubMed  CAS  Google Scholar 

  • Hsu FL, Lai CW, Cheng JT (1997) Antihyperglycemic effects of paeoniflorin and 8-debenzoylpaeoniflorin, glucosides from the root of Paeonia lactiflora. Planta Med 63(4):323–325

    Article  PubMed  CAS  Google Scholar 

  • Hu SY (2005) Food plants of China. The Chinese University Press, Hong Kong, 844 pp

    Google Scholar 

  • Huxley AJ, Griffiths M, Levy M (eds) (1992) The new RHS dictionary of gardening, 4 vols. MacMillan, New York

    Google Scholar 

  • Ikuta A, Kamiya K, Satake T, Saiki Y (1995) Triterpenoids from callus tissue cultures of Paeonia species. Phytochemistry 38(5):1203–1207

    Article  CAS  Google Scholar 

  • Im DY, Lee KI (2011) Tyrosinase inhibitory activity and melanin production inhibitory activity of the extract and fractions from paeoniae radix. Korean J Pharmacogn 42(4):323–328

    Google Scholar 

  • Im DY, Lee KI (2012) Nitric oxide production inhibitory effect and antibacterial activity of the extract and fractions from paeoniae radix. Korean J Pharmacogn 43(2):173–178

    Google Scholar 

  • Ji Q, Yang L, Zhou J, Lin R, Zhang J, Lin Q, Wang W, Zhang K (2012) Protective effects of paeoniflorin against cobalt chloride-induced apoptosis of endothelial cells via HIF-1α pathway. Toxicol In Vitro 26(3):455–461

    Article  PubMed  CAS  Google Scholar 

  • Jia YB, Tang TQ (1991) Paeonia lactiflora injection in treating chronic cor pulmonale with pulmonary hypertension. Zhong Xi Yi Jie He Za Zhi 11(4):199–202 (in Chinese)

    PubMed  CAS  Google Scholar 

  • Jian ZY, Yu JB, Wang WQ (2010) RP-HPLC determination of main chemical components in different parts and different harvest periods of Paeonia lactiflora. Yao Xue Xue Bao 45(4):489–493 (in Chinese)

    PubMed  CAS  Google Scholar 

  • Jiang D, Chen Y, Hou X, Xu J, Mu X, Chen W (2011) Influence of Paeonia lactiflora roots extract on cAMP-phosphodiesterase activity and related anti-inflammatory action. J Ethnopharmacol 137(1):914–920

    Article  PubMed  Google Scholar 

  • Jin SN, Wen JF, Wang TT, Kang DG, Lee HS, Cho KW (2012) Vasodilatory effects of ethanol extract of Radix Paeoniae Rubra and its mechanism of action in the rat aorta. J Ethnopharmacol 142(1):188–193

    Article  PubMed  CAS  Google Scholar 

  • Juan YC, Tsai WJ, Lin YL, Wang GJ, Cheng JJ, Yang HY, Hsu CY, Liu HK (2010) The novel anti-hyperglycemic effect of Paeoniae radix via the transcriptional suppression of phosphoenopyruvate carboxykinase (PEPCK). Phytomedicine 17(8–9):626–634

    Article  PubMed  CAS  Google Scholar 

  • Juan YC, Chang CC, Tsai WJ, Lin YL, Hsu YS, Liu HK (2011) Pharmacological evaluation of insulin mimetic novel suppressors of PEPCK gene transcription from Paeoniae Rubra Radix. J Ethnopharmacol 137(1):592–600

    Article  PubMed  Google Scholar 

  • Kadota S, Terashima S, Kikuchi T, Namba T (1992) Palbinone, a potent inhibitor of 3α-hydroxy dehydrogenase from Paeonia albiflora. Tetrahedron Lett 33(2):255–256

    Article  CAS  Google Scholar 

  • Kadota S, Terashima S, Basnet P, Kikuchi T, Namba T (1993) Palbinone, a novel terpenoid from Paeonia albiflora; potent inhibitory activity on 3 alpha-hydroxysteroid dehydrogenase. Chem Pharm Bull (Tokyo) 41(3):487–490

    Article  CAS  Google Scholar 

  • Kajiwara K, Sunaga K, Tsuda T, Sugaya A, Sugaya E, Kimura M (2008) Peony root extract upregulates transthyretin and phosphoglycerate mutase in mouse cobalt focus seizure. Biochem Biophys Res Commun 371(3):375–379

    Article  PubMed  CAS  Google Scholar 

  • Kamiya K, Yoshioka K, Saiki Y, Ikuta A, Satake T (1997) Triterpenoids and flavonoids from Paeonia lactiflora. Phytochemistry 44(1):141–144

    Article  CAS  Google Scholar 

  • Kaneda M, Itaka Y, Shibata S (1972) Chemical studies on the oriental plant drugs Part 33. The absolute structures of paeoniflorin, albiflorin and benzoyl paeoniflorin isolated from Chinese peony root. Tetrahedron 28:4309–4317

    Article  CAS  Google Scholar 

  • Kang SS, Shin KH, Chi HJ (1991) Galloylpaeoniflorin, a new acylated monoterpene glucoside from paeony root. Arch Pharm Res 14(1):52–54

    Article  PubMed  CAS  Google Scholar 

  • Kang JH, Park YH, Choi SW, Yang EK, Lee WJ (2003) Resveratrol derivatives potently induce apoptosis in human promyelocytic leukemia cells. Exp Mol Med 35(6):467–474

    Article  PubMed  CAS  Google Scholar 

  • Kazuhiko S, Ryoichi K, Ken’ichi A, Yasushi K, YujI I (2000) Volatile components of peony flowers. Koryo Terupen oyobi Seiyu Kagaku ni kansuru Toronkai Koen Yoshishu 44:47–49

    Google Scholar 

  • Kim HJ, Chang EJ, Bae SJ, Shim SM, Park HD, Rhee CH, Park JH, Choi SW (2002a) Cytotoxic and antimutagenic stilbenes from seeds of Paeonia lactiflora. Arch Pharm Res 25(3):293–299

    Article  PubMed  CAS  Google Scholar 

  • Kim HJ, Chang EJ, Cho SH, Chung SK, Park HD, Choi SW (2002b) Antioxidative activity of resveratrol and its derivatives isolated from seeds of Paeonia lactiflora. Biosci Biotechnol Biochem 66(9):1990–1993

    Article  PubMed  CAS  Google Scholar 

  • Kim HJ, Ha SC, Choi SW (2002c) Inhibition of tyrosinase and lipoxygenase activities by resveratrol and its derivatives from seeds of Paeonia lactiflora. Nutraceut Food 7(4):447–450

    Article  CAS  Google Scholar 

  • Kim J, Yean M, Lee J, Kim Y, Lee E, Lee S, Kang S (2008) A new monoterpene glucoside from the roots of Paeonia lactiflora. Helv Chim Acta 91:85–89

    Article  CAS  Google Scholar 

  • Kim SH, Lee MK, Lee KY, Sung SH, Kim J, Kim YC (2009) Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro. J Enzym Inhib Med Chem 24(5):1138–1140

    Article  CAS  Google Scholar 

  • Koo YK, Kim JM, Koo JY, Kang SS, Bae K, Kim YS, Chung JH, Yun-Choi HS (2010) Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa. Pharmazie 65(8):624–628

    PubMed  CAS  Google Scholar 

  • Kumagai Y, Hyuga S, Hyuga M, Watanabe K, Kawanishi T, Hanawa T (2005) Estrogen-like activity in Kampo medicines used for menopausal symptoms and gynecological diseases. J Tradit Med 22:28–236

    Google Scholar 

  • Kumar N, Motto MG (1986) Volatile constituents of peony flowers. Phytochemistry 25(1):250–253

    Article  CAS  Google Scholar 

  • Kunkel G (1984) Plants for human consumption. An annotated checklist of the edible phanerogams and ferns. Koeltz Scientific Books, Koenigstein

    Google Scholar 

  • Kuo JJ, Wang CY, Lee TF, Huang YT, Lin YL (2012) Paeoniae radix reduces PDGF-stimulated hepatic stellate cell migration. Planta Med 78(4):341–348

    Article  PubMed  CAS  Google Scholar 

  • Kwon KB, Kim EK, Han MJ, Shin BC, Park YK, Kim KS, Lee YR, Park JW, Park BH, do Ryu G (2006) Induction of apoptosis by Radix Paeoniae Alba extract through cytochrome c release and the activations of caspase-9 and caspase-3 in HL-60 cells. Biol Pharm Bull 29(6):1082–1086

    Article  PubMed  CAS  Google Scholar 

  • Lang HY, Li SZ, Laing XT (1983) Study on chemical components or Radix Peoniae Rubra. Acta Pharm Sin 18(7):551–552 (in Chinese)

    CAS  Google Scholar 

  • Lang HY, Li SZ, McCabe T, Clardy J (1984) A new monoterpene glycoside of Paeonia lactiflora. Planta Med 50(06):501–504

    Article  PubMed  CAS  Google Scholar 

  • Lee SM, Li ML, Tse YC, Leung SC, Lee MM, Tsui SK, Fung KP, Lee CY, Waye MM (2002) Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. Life Sci 71(19):2267–2277

    Article  PubMed  CAS  Google Scholar 

  • Lee SJ, Lee IS, Mar W (2003) Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity by 1,2,3,4,6-penta-O-galloyl-beta-d-glucose in murine macrophage cells. Arch Pharm Res 26(10):832–839

    Article  PubMed  CAS  Google Scholar 

  • Lee SJ, Lee HM, Ji ST, Lee SR, Mar W, Gho YS (2004) 1,2,3,4,6-Penta-O-galloyl-beta-d-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor. Cancer Lett 208(1):89–94

    Article  PubMed  CAS  Google Scholar 

  • Lee SC, Kwon YS, Son KH, Kim HP, Heo MY (2005) Antioxidative constituents from Paeonia lactiflora. Arch Pharm Res 28(7):775–783

    Article  PubMed  CAS  Google Scholar 

  • Lee SJ, Lee HK, Jung MK, Mar W (2006) In vitro antiviral activity of 1,2,3,4,6-penta-O-galloyl-beta-d-glucose against hepatitis B virus. Biol Pharm Bull 29(10):2131–2134

    Article  PubMed  CAS  Google Scholar 

  • Lee B, Shin YW, Bae EA, Han SJ, Kim JS, Kang SS, Kim DH (2008a) Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol. Arch Pharm Res 31(4):445–450

    Article  PubMed  CAS  Google Scholar 

  • Lee SM, Yoon MY, Park HR (2008b) Protective effects of Paeonia lactiflora Pall on hydrogen peroxide-induced apoptosis in PC12 cells. Biosci Biotechnol Biochem 72(5):1272–1277

    Article  PubMed  CAS  Google Scholar 

  • Lee S, Khoo CS, Hennell JR, Pearson JL, Jarouche M, Halstead CW, Bensoussan A (2009) LC determination of albiflorin and paeoniflorin in Bai Shao (Paeonia lactiflora) as a raw herb and dried aqueous extract. J AOAC Int 92(4):1027–1034

    PubMed  CAS  Google Scholar 

  • Leem K, Kim H, Boo Y, Lee HS, Kim JS, Yoo YC, Ahn HJ, Park HJ, Seo JC, Kim HK, Jin SY, Park HK, Chung JH, Cho JJ (2004) Effects of Paeonia lactiflora root extracts on the secretions of monocyte chemotactic protein-1 and -3 in human nasal fibroblasts. Phytother Res 18(3):241–243

    Article  PubMed  CAS  Google Scholar 

  • Li J, Xiong X, Liu Y (2007a) Protective effect of paeoniflorin against optic nerve crush. J Huazhong Univ Sci Technolog Med Sci 27(6):650–652

    Article  PubMed  CAS  Google Scholar 

  • Li XR, Lan ZG, Liang YZ (2007b) Analysis of volatile chemical components of Radix Paeoniae Rubra by gas chromatography–mass spectrometry and chemometric resolution. J Cent South Univ Technol 14(1):57–61

    Article  CAS  Google Scholar 

  • Li J, Chen CX, Shen YH (2011a) Effects of total glucosides from paeony (Paeonia lactiflora Pall) roots on experimental atherosclerosis in rats. J Ethnopharmacol 135(2):469–475

    Article  PubMed  CAS  Google Scholar 

  • Li YF, Wang M, Wang XY, Yu HS, Kang LP, Ma BP, Ruan JX, Zhang ZQ (2011b) Pharmacokinetic properties of albiflorin and paeoniflorin after oral administration of pure compound, Radix Paeoniae alba extract and danggui-shaoyao-san extract to rats. J Asian Nat Prod Res 13(2):117–127

    Article  PubMed  CAS  Google Scholar 

  • Li PP, Liu DD, Liu YJ, Song SS, Wang QT, Chang Y, Wu YJ, Chen JY, Zhao WD, Zhang LL, Wei W (2012) BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin. J Ethnopharmacol 141(1):290–300

    Article  PubMed  CAS  Google Scholar 

  • Li CL, He J, Li ZG, Zheng LW, Hua H (2013) Effects of total glucosides of paeony for delaying onset of Sjogren’s syndrome: an animal study. J Cranomaxillofac Surg 41(7):610–615

    Article  Google Scholar 

  • Liang J, Xu F, Zhang YZ, Huang S, Zang XY, Zhao X, Zhang L, Shang MY, Yang DH, Wang X, Cai SQ (2013) The profiling and identification of the absorbed constituents and metabolites of Paeoniae Radix Rubra decoction in rat plasma and urine by the HPLC-DAD-ESI-IT-TOF-MS(n) technique: a novel strategy for the systematic screening and identification of absorbed constituents and metabolites from traditional Chinese medicines. J Pharm Biomed Anal 83:108–121

    Article  PubMed  CAS  Google Scholar 

  • Lin HR (2013) Paeoniflorin acts as a liver X receptor agonist. J Asian Nat Prod Res 15(1):35–45

    Article  PubMed  CAS  Google Scholar 

  • Lin TJ, Wang KC, Lin CC, Chiang LC, Chang JS (2013) Anti-viral activity of water extract of Paeonia lactiflora Pallas against human respiratory syncytial virus in human respiratory tract cell lines. Am J Chin Med 41(3):585–599

    Article  PubMed  Google Scholar 

  • Liu DF, Wei W, Song LH (2006) Protective effect of paeoniflorin on immunological liver injury induced by bacillus Calmette-Guerin plus lipopolysaccharide: modulation of tumour necrosis factor-alpha and interleukin-6 MRNA. Clin Exp Pharmacol Physiol 33(4):332–339

    Article  PubMed  CAS  Google Scholar 

  • Liu GL, Li YC, Shen YJ (2010) Inhibitory effect of total glucosides of paeonia on the NF-κB/p65 protein expression in paws of RA rats. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26(11):1082–1084 (in Chinese)

    PubMed  CAS  Google Scholar 

  • Long JG, Gao ML, Kong Y, Shen X, Du XY, Son YO, Shi XL, Liu JK, Mo XY (2012) Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats. Phytomedicine 19(8):672–676

    Article  PubMed  CAS  Google Scholar 

  • Ma RQ, Chen JW, Pang JX, Lan XJ, Qiu CH (2005) Protective effects of total paeony glycoside against global cerebral ischemia-reperfusion injury in gerbils. Di Yi Jun Yi Da Xue Xue Bao 25(4):471–473

    PubMed  CAS  Google Scholar 

  • Malviya N, Jain S (2009) Wound healing activity of aqueous extract of Radix paeoniae root. Acta Pol Pharm 66(5):543–547

    PubMed  Google Scholar 

  • Mao QQ, Huang Z, Ip SP, Che CT (2008a) Antidepressant-like effect of ethanol extract from Paeonia lactiflora in mice. Phytother Res 22(11):1496–1499

    Article  PubMed  Google Scholar 

  • Mao QQ, Ip SP, Tsai SH, Che CT (2008b) Antidepressant-like effect of peony glycosides in mice. J Ethnopharmacol 119(2):272–275

    Article  PubMed  CAS  Google Scholar 

  • Mao QQ, Ip SP, Ko KM, Tsai SH, Che CT (2009a) Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor. Prog Neuropsychopharmacol Biol Psychiatry 33(7):1211–1216

    Article  PubMed  CAS  Google Scholar 

  • Mao QQ, Ip SP, Ko KM, Tsai SH, Xian YF, Che CT (2009b) Effects of peony glycosides on mice exposed to chronic unpredictable stress: further evidence for antidepressant-like activity. J Ethnopharmacol 124(2):316–320

    Article  PubMed  CAS  Google Scholar 

  • Mao QQ, Ip SP, Ko KM, Tsai SH, Zhao M, Che CT (2009c) Peony glycosides protect against corticosterone-induced neurotoxicity in PC12 cells. Cell Mol Neurobiol 29(5):643–647

    Article  PubMed  CAS  Google Scholar 

  • Mao QQ, Xian YF, Ip SP, Tsai SH, Che CT (2010) Long-term treatment with peony glycosides reverses chronic unpredictable mild stress-induced depressive-like behavior via increasing expression of neurotrophins in rat brain. Behav Brain Res 210(2):171–177

    Article  PubMed  CAS  Google Scholar 

  • Mao QQ, Ip SP, Xian YF, Hu Z, Che CT (2012) Anti-depressant-like effect of peony: a mini-review. Pharm Biol 50(1):72–77

    Article  PubMed  CAS  Google Scholar 

  • Min CY, Liu HQ, Zhan F, Qiu WZ (2009) Effect of paeonol on protecting endothelial cells of diabetic rats]. Zhong Yao Cai 32(4):564–567 (in Chinese)

    PubMed  CAS  Google Scholar 

  • Miyazawa M, Maruyama H, Kameoka H (1984) Essential oil constituents of “Paeoniae Radix” Paeonia lactiflora Pall. (P. albiflora Pall.). Agric Biol Chem 48(11):2847–2849

    Article  CAS  Google Scholar 

  • Murakami N, Saka M, Shimada H, Matsuda H, Yamahara J, Yoshikawa M (1996) New bioactive monoterpene glycosides from Paeoniae Radix. Chem Pharm Bull 44(6):1279–1281

    Article  PubMed  CAS  Google Scholar 

  • Nam KN, Yae CG, Hong JW, Cho DH, Lee JH, Lee EH (2013) Paeoniflorin, a monoterpene glycoside, attenuates lipopolysaccharide-induced neuronal injury and brain microglial inflammatory response. Biotechnol Lett 35(8):1183–1189

    Article  PubMed  CAS  Google Scholar 

  • Natural Products Research Institute, Seoul National University (1998) Medicinal plants in the Republic of Korea. WHO Regional Publications, Western Pacific Series No 21, Seoul, Korea 316 pp

    Google Scholar 

  • Ngan LT, Moon JK, Kim JH, Shibamoto T, Ahn YJ (2012a) Growth-inhibiting effects of Paeonia lactiflora root steam distillate constituents and structurally related compounds on human intestinal bacteria. World J Microbiol Biotechnol 28(4):1575–1583

    Article  PubMed  CAS  Google Scholar 

  • Ngan LT, Moon JK, Shibamoto T, Ahn YJ (2012b) Growth-inhibiting, bactericidal, and urease inhibitory effects of Paeonia lactiflora root constituents and related compounds on antibiotic-susceptible and -resistant strains of Helicobacter pylori. J Agric Food Chem 60(36):9062–9073

    Article  PubMed  CAS  Google Scholar 

  • Nguyen DV (1993) Medicinal plants of Vietnam, Cambodia, and Laos. Mekong Printing, Santa Monica, 528 pp

    Google Scholar 

  • Nishizawa M, Yamagishi T, Nonaka GI, Nishioka I (1980) Structure of gallotannins in Paeoniae Radix. Chem Pharm Bull 28(9):2850–2852

    Article  CAS  Google Scholar 

  • Nishizawa M, Yamagishi T, Nonaka G, Nishioka I, Nagasawa T, Oura H (1983a) Tannins and related compounds. XII. Isolation and characterization of galloylglucoses from Paeoniae Radix and their effects on urea-nitrogen concentration in rat serum. Chem Pharm Bull (Tokyo) 31(8):2593–2600

    Article  CAS  Google Scholar 

  • Nishizawa M, Yamagishi T, Ohyama T (1983b) Inhibitory effect of gallotannins on the respiration of rat liver mitochondria. Chem Pharm Bull 31:2150–2152

    Article  PubMed  CAS  Google Scholar 

  • Nizamutdinova IT, Oh HM, Min YN, Park SH, Lee MJ, Kim JS, Yean MH, Kang SS, Kim YS, Chang KC, Kim HJ (2007) Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB signaling pathways. Int Immunopharmacol 7(3):343–350

    Article  PubMed  CAS  Google Scholar 

  • Nizamutdinova IT, Jin YC, Kim JS, Yean MH, Kang SS, Kim YS, Lee JH, Seo HG, Kim HJ, Chang KC (2008) Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats. Planta Med 74(1):14–18

    Article  PubMed  CAS  Google Scholar 

  • Ou TT, Wu CH, Hsu JD, Chyau CC, Lee HJ, Wang CJ (2011) Paeonia lactiflora Pall inhibits bladder cancer growth involving phosphorylation of Chk2 in vitro and in vivo. J Ethnopharmacol 135(1):162–172

    Article  PubMed  Google Scholar 

  • Page M (1997) The gardener’s guide to growing peonies. Timber Press, Portland, 160 pp

    Google Scholar 

  • Pham HY, Phan VK, Nguyen XN, Nugyen HT, Tran HQ, Chau VM, Jung WK, Eun MC, Young HK (2007) A new monoterpene glycoside from the roots of Paeonia lactiflora increases the differentiation of osteoblastic MC3T3-E1 cells. Arch Pharm Res 30(10):1179–1185

    Article  Google Scholar 

  • Qi XG (1991) Protective mechanism of Salvia miltiorrhiza and Paeonia lactiflora for experimental liver damage. Zhong Xi Yi Jie He Za Zhi 11(2):102–104, 69 (in Chinese).

    Google Scholar 

  • Ren ML, Zhang X, Ding R, Dai Y, Tu FJ, Cheng YY, Yao XS (2009) Two new monoterpene glucosides from Paeonia lactiflora Pall. J Asian Nat Prod Res 11(7):670–674

    Article  PubMed  CAS  Google Scholar 

  • Shibata S, Nakara M (1963) Studies on the constituents of Japanese and Chinese crude drugs. VIII. Paeoniflorin, a glucoside on Chinese paeony root. (1). Chem Pharm Bull 11:372–378

    Article  CAS  Google Scholar 

  • Shibata S, Nakara M, Aimi N (1963) The constituents of Japanese and Chinese crude drugs. IX. Paeoniflorin. A glucoside of Chinese peony roots. Chem Pharm Bull 11:379–391

    Article  CAS  Google Scholar 

  • Shibutani S, Nagasawa T, Oura H, Nonata G, Nishioka I (1981) Effect of extract from Paeoniae radix on urea-nitrogen concentration in rat serum. Chem Pharm Bull 29:874–878

    Article  PubMed  CAS  Google Scholar 

  • Shimizu M, Hayashiu T, Morita N, Kimura I, Kimura M, Kiuchi F, Noguchi H, Iitaka Y, Sankawa U (1981) Paeoniflorigenone a new monoterpene from peony Paeonia albiflora roots. Tetrahedron Lett 22:3069–3070

    Article  CAS  Google Scholar 

  • Shimizu M, Hayashi T, Morita N, Kuchi F, Noguchi H, Iitaka Y, Sankawa U (1983) The structure of paeoniflorigenone a new monoterpene isolated from paeoniae radix. Chem Pharm Bull 31(2):577–583

    Article  CAS  Google Scholar 

  • Shu YZ, Hattori M, Akao T, Kobashi K, Kagei K, Fukuyama K, Tsukihara T, Namba T (1987) Metabolism of paeoniflorin and related compounds by human intestinal bacteria. II.: structures of 7S-and 7R-paeonimetabolines I and II formed by Bacteroides fragilis and Lactobacillus brevis. Chem Pharm Bull 35(9):726–3733

    Article  Google Scholar 

  • Son KH, Heo MY (2013) Inhibitory effects of Korean indigenous plants on tyrosinase and melanogenesis. J Cosmet Sci 64(2):145–158

    CAS  Google Scholar 

  • Steenbergs Organic (2012) Peony flowers 6G Edible Culinary. Steenberg Organic Company, United Kingdom. http://www.steenbergs.co.uk/product/1150/peony-flowers-6g-edible-culinary/1/69

  • Su J, Zhang P, Zhang JJ, Qi XM, Wu YG, Shen JJ (2010a) Effects of total glucosides of paeony on oxidative stress in the kidney from diabetic rats. Phytomedicine 17(3–4):254–260

    Article  PubMed  CAS  Google Scholar 

  • Su SY, Cheng CY, Tsai TH, Hsiang CY, Ho TY, Hsieh CL (2010b) Paeonol attenuates H2O2-induced NF-κB-associated amyloid precursor protein expression. Am J Chin Med 38(6):1171–1192

    Article  PubMed  CAS  Google Scholar 

  • Sugaya E, Jin W, Sugaya A, Sunaga K, Tsuda T (2006) Inhibitory effects of peony root extract on the large conductance calcium-activated potassium current essential in production of bursting activity. J Herb Pharmacother 6(2):65–77

    Article  PubMed  Google Scholar 

  • Suh KS, Choi EM, Lee YS, Kim YS (2013) Protective effect of albiflorin against oxidative-stress-mediated toxicity in osteoblast-like MC3T3-E1 cells. Fitoterapia 89:33–41

    Article  PubMed  CAS  Google Scholar 

  • Sun WY, Wei W, Wu L, Gui SY, Wang H (2007) Effects and mechanisms of extract from Paeonia lactiflora and Astragalus membranaceus on liver fibrosis induced by carbon tetrachloride in rats. J Ethnopharmacol 112(3):514–523

    Article  PubMed  Google Scholar 

  • Sun WY, Wei W, Gui SY, Wu L, Wang H (2008) Protective effect of extract from Paeonia lactiflora and Astragalus membranaceus against liver injury induced by Bacillus Calmette-Guérin and lipopolysaccharide in mice. Basic Clin Pharmacol Toxicol 103(2):143–149

    Article  PubMed  CAS  Google Scholar 

  • Sun WY, Wang L, Liu H, Li X, Wei W (2012) A standardized extract from Paeonia lactiflora and Astragalus membranaceus attenuates liver fibrosis induced by porcine serum in rats. Int J Mol Med 29(3):491–498

    PubMed  Google Scholar 

  • Tabata K, Matsumoto K, Murakami Y, Watanabe H (2001) Ameliorative effects of paeoniflorin, a major constituent of peony root, on adenosine A1 receptor-mediated impairment of passive avoidance performance and long-term potentiation in the hippocampus. Biol Pharm Bull 24(5):496–500

    Article  PubMed  CAS  Google Scholar 

  • Takagi K, Harada M (1969a) Pharmacological studies on herb paeony root. I. Central effects of paeoniflorin and combined effects with licorice component FM 100. Yakugaku Zasshi 89(7):879–886 (in Japanese)

    PubMed  CAS  Google Scholar 

  • Takagi K, Harada M (1969b) Pharmacological studies on herb paeony root. II.: Anti-inflammatory effect, inhibitory effect on gastric juice secretion, preventive effect on stress ulcer, antidiuretic effect of paeoniflorin and combined effects with licorice component FM 100. Yakugaku Zasshi 89(7):887–892 (in Japanese)

    PubMed  CAS  Google Scholar 

  • Takagi K, Harada M (1969c) Pharmacological studies on herb paeony root. III.: effects of paeoniflorin on circulatory and respiratory systems and isolated organs. Yakugaku Zasshi 89:893–898

    PubMed  CAS  Google Scholar 

  • Takeda S, Isono T, Wakui Y, Matsuzaki Y, Sasaki H, Amagaya S, Maruno M (1995) Absorption and excretion of paeoniflorin in rats. J Pharm Pharmacol 47(12):1036–1040

    Article  PubMed  CAS  Google Scholar 

  • Tan JJ, Zhao QC, Yang L, Shang ZP, Du ZQ, Yan M (2010) Chemical constituents in roots of Paeonia lactiflora. Chin Tradit Herb Drug 41(8):1245–1248

    CAS  Google Scholar 

  • Tanaka T, Kataoka M, Tsuboi N, Kouno I (2000) New monoterpene glycoside esters and phenolic constituents of paeoniae radix, and increase of water solubility of proanthocyanidins in the presence of paeoniflorin. Chem Pharm Bull 48(2):201–207

    Article  PubMed  CAS  Google Scholar 

  • Tanaka T, Fukumori M, Ochi T, Kouno I (2003) Paeonianins A-E, new dimeric and monomeric ellagitannins from the fruits of Paeonia lactiflora. J Nat Prod 66(6):759–763

    Article  PubMed  CAS  Google Scholar 

  • Tang LM, Liu IM, Cheng JT (2003) Stimulatory effect of paeoniflorin on adenosine release to increase the glucose uptake into white adipocytes of Wistar rat. Planta Med 69(4):332–336

    Article  PubMed  CAS  Google Scholar 

  • Tang NY, Liu CH, Hsieh CT, Hsieh CL (2010) The anti-inflammatory effect of paeoniflorin on cerebral infarction induced by ischemia-reperfusion injury in Sprague–Dawley rats. Am J Chin Med 38(1):51–64

    Article  PubMed  CAS  Google Scholar 

  • The Plant List (2013) Paeonia lactiflora. http://www.theplantlist.org/

  • Tomoda M, Matsumoto K, Shimizu N, Gonda R, Ohara N, Hirabayashi K (1994) An acidic polysaccharide with immunological activities from the root of Paeonia lactiflora. Biol Pharm Bull 17(9):1161–1164

    Article  PubMed  CAS  Google Scholar 

  • Tsai TY, Wu SN, Liu YC, Wu AZ, Tsai YC (2005) Inhibitory action of L-type Ca2+ current by paeoniflorin, a major constituent of peony root, in NG108-15 neuronal cells. Eur J Pharmacol 523(1–3):16–24

    Article  PubMed  CAS  Google Scholar 

  • Tsai HY, Lin HY, Fong YC, Wu JB, Chen YF, Tsuzuki M, Tang CH (2008) Paeonol inhibits RANKL-induced osteoclastogenesis by inhibiting ERK, p38 and NF-kappaB pathway. Eur J Pharmacol 588(1):124–133

    Article  PubMed  CAS  Google Scholar 

  • Tsuboi H, Hossain K, Akhand AA, Takeda K, Du J, Rifa’i M, Dai Y, Hayakawa A, Suzuki H, Nakashima I (2004) Paeoniflorin induces apoptosis of lymphocytes through a redox-linked mechanism. J Cell Biochem 93(1):162–172

    Article  PubMed  CAS  Google Scholar 

  • Uphof JCT (1968) Dictionary of economic plants, 2nd ed. (1st ed. 1959). Cramer, Lehre, 591 pp

    Google Scholar 

  • Wang Y, Ma R (1990) Effect of an extract of Paeonia lactiflora on the blood coagulative and fibrinolytic enzymes. Zhong Xi Yi Jie He Za Zhi 10(2):101–102, 70 (in Chinese)

    Google Scholar 

  • Wang Y, Xing HY (2007) Clinical observation on effect of total glucosides of paeony combined with methotrexate on rheumatoid arthritis. Zhongguo Zhong Xi Yi Jie He Za Zhi 27(9):839–840 (in Chinese)

    PubMed  Google Scholar 

  • Wang H, Wei W, Wang NP, Wu CY, Yan SX, Yue L, Zhang LL, Xu SY (2005) Effects of total glucosides of peony on immunological hepatic fibrosis in rats. World J Gastroenterol 11(14):2124–2129

    PubMed  CAS  Google Scholar 

  • Wang XL, Jiao W, Liao X, Peng SL, Ding LS (2006a) Monoterpene glycosides from the roots of Paeonia lactiflora. Chin Chem Lett 17(7):916–918

    CAS  Google Scholar 

  • Wang YZ, Shi RB, Liu B (2006b) Isolation and structure identification of chemical principles from Paeonia lactiflora Pall. J Beijing Univ Tradit Chin Med 29(4):267–269

    Google Scholar 

  • Wang SL, Wang JP, Bian H (2007) Clinical observation on total glucosides of paeony combined with sulfasalazine in treatment of ankylosing spondylitis. Zhongguo Zhong Xi Yi Jie He Za Zhi 27(3):217–219 (in Chinese)

    PubMed  CAS  Google Scholar 

  • Wang KC, Zhang RR, Fang Z, Shen MJ (2008) Analysis of benzoic acid content in Radix Paeoniae Alba treated by different process. Zhong Yao Cai 31(10):1476–1478 (in Chinese)

    PubMed  CAS  Google Scholar 

  • Wang HB, Gu WF, Chu WJ, Zhang S, Tang XC, Qin GW (2009) Monoterpene glucosides from Paeonia lactiflora. J Nat Prod 72(7):1321–1324

    Article  PubMed  CAS  Google Scholar 

  • Wang K, Wu YG, Su J, Zhang JJ, Zhang P, Qi XM (2012a) Total glucosides of paeony regulates JAK2/STAT3 activation and macrophage proliferation in diabetic rat kidneys. Am J Chin Med 40(3):521–536

    Article  PubMed  CAS  Google Scholar 

  • Wang Q, Wang W, Wei S, Yu F, Peng F, Fang Y (2012b) Study on effect of different processing methods on seven main chemical components of wild and cultivated Paeonia lactiflora. Zhongguo Zhong Yao Za Zhi 37(7):920–924 (in Chinese)

    PubMed  CAS  Google Scholar 

  • Wang D, Tan QR, Zhang ZJ (2013a) Neuroprotective effects of paeoniflorin, but not the isomer albiflorin, are associated with the suppression of intracellular calcium and calcium/calmodulin protein kinase II in PC12 cells. J Mol Neurosci 51(2):581–590

    Article  PubMed  CAS  Google Scholar 

  • Wang D, Wong HK, Feng YB, Zhang ZJ (2013b) Paeoniflorin, a natural neuroprotective agent, modulates multiple anti-apoptotic and pro-apoptotic pathways in differentiated PC12 cells. Cell Mol Neurobiol 33(4):521–529

    Article  PubMed  CAS  Google Scholar 

  • Washida K, Itoh Y, Iwashita T, Nomoto K (2009a) Androgen modulators from the roots of Paeonia lactiflora (paeoniae radix) grown and processed in Nara Prefecture, Japan. Chem Pharm Bull 57:971–974

    Article  PubMed  CAS  Google Scholar 

  • Washida K, Yamagaki T, Iwashita T, Nomoto K (2009b) Two new galloylated monoterpene glycosides, 4-o-galloylalbiflorin and 4′-o-galloylpaeoniflorin, from the roots of Paeonia lactiflora (paeoniae radix) grown and processed in Nara Prefecture, Japan. Chem Pharm Bull 57(10):1150–1152

    Article  PubMed  CAS  Google Scholar 

  • Watanabe K, Hyuga S, Hyuga M, Kawanishi T, Hanawa T (2006) Agonistic or antagonistic action of Kampo medicines used for menopausal symptoms at estrogen receptor subtypes, ER α and ER β. J Tradit Med 23:203–207

    Google Scholar 

  • Wu H, Wei W, Song L, Zhang L, Chen Y, Hu X (2007) Paeoniflorin induced immune tolerance of mesenteric lymph node lymphocytes via enhancing beta 2-adrenergic receptor desensitization in rats with adjuvant arthritis. Int Immunopharmacol 7(5):662–673

    Article  PubMed  CAS  Google Scholar 

  • Wu J, Yao N, Wang DW (2008) Determination of paeoniflorin in rat plasma by HPLC-MS/MS and its pharmacokinetics. Zhongguo Zhong Yao Za Zhi 33(20):2369–2373 (in Chinese)

    PubMed  CAS  Google Scholar 

  • Wu Y, Ren K, Liang C, Yuan L, Qi X, Dong J, Shen J, Lin S (2009) Renoprotective effect of total glucosides of paeony (TGP) and its mechanism in experimental diabetes. J Pharmacol Sci 109(1):78–87

    Article  PubMed  CAS  Google Scholar 

  • Wu SH, Wu DG, Chen YW (2010) Chemical constituents and bioactivities of plants from the genus Paeonia. Chem Biodivers 7(1):90–104

    Article  PubMed  CAS  Google Scholar 

  • Xiao L, Wang YZ, Liu J, Luo XT, Ye Y, Zhu XZ (2005) Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats. Life Sci 78:413–420

    Article  PubMed  CAS  Google Scholar 

  • Xie WG, Ma XC, Shao NS (2005) Preliminary study on change of serum proteome in noxious heat blood stasis syndrome treated by radix Paeoniae rubra. Zhongguo Zhong Xi Yi Jie He Za Zhi 25(6):520–524 (In Chinese)

    PubMed  Google Scholar 

  • Xie WK, Yu WZ, Zhao M, Zhou WY, Chen H, Du W, Huang LZ, Xu YS, Li XX (2011) Protective effect of paeoniflorin against oxidative stress in human retinal pigment epithelium in vitro. Mol Vis 17:3512–3522

    CAS  Google Scholar 

  • Xu HY (1986) Studies on the isolation, identification and bioactivities of daucosterol in the roots of Paeonia lactiflora. Acta Bot Sin 28(2):169–174

    CAS  Google Scholar 

  • Xu HM, Wei W, Jia XY, Chang Y, Zhang L (2007) Effects and mechanisms of total glucosides of paeony on adjuvant arthritis in rats. J Ethnopharmacol 109(3):442–448

    Article  PubMed  CAS  Google Scholar 

  • Xu RS, Mao CP, Yu RP, Cheng CG (2008) Determination of trace elements in radix Paeoniae alba by microwave digestion-ICP-AES. Guang Pu Xue Yu Guang Pu Fen Xi 28(3):671–674 (in Chinese)

    PubMed  Google Scholar 

  • Xu H, Song J, Gao X, Xu Z, Xu X, Xia Y, Dai Y (2013) Paeoniflorin attenuates lipopolysaccharide-induced permeability of endothelial cells: involvements of F-actin expression and phosphorylations of PI3K/Akt and PKC. Inflammation 36(1):216–225

    Article  PubMed  CAS  Google Scholar 

  • Yamashita Y, Tanaka K, Tamaki O, Hosoda K, Noguchi M (1994) Studies on the good varieties of Paeoniae radix: I. Yield of root, paeoniflorin and tannin contents in Paeoniae radix. Shoyakugaku Zasshi 47:434–439

    Google Scholar 

  • Yang HO, Ko WK, Kim JY, Ro HS (2004) Paeoniflorin: an antihyperlipidemic agent from Paeonia lactiflora. Fitoterapia 75(1):45–49

    Article  PubMed  CAS  Google Scholar 

  • Yang L, Xu SJ, Tian RT, Xie PS, Wang ZT (2007) HPLC fingerprinting of radix paeoniae alba. Yao Xue Xue Bao 42(1):71–74 (in Chinese)

    PubMed  Google Scholar 

  • Yang L, Xu SJ, Feng QR, Liu HP, Tian RT, Xie PS (2009) A simple thin-layer chromatographic fingerprint method for distinguishing between radix paeoniae rubra and radix paeoniae alba. J Liq Chromatogr Relat Technol 32:2893–2905

    Article  CAS  Google Scholar 

  • Yean MH, Lee JY, Kim JS, Kang SS (2008) Phytochemical studies on paeoniae radix (1)-monoterpene glucosides. Korean J Pharmacogn 39(a):19–27

    CAS  Google Scholar 

  • Yeung HC (1985) Handbook of Chinese herbs and formulas, 2nd edn. Redwing Book, Taos, 431 pp

    Google Scholar 

  • Yu J, Elix JA, Iskander MN (1990) Lactiflorin, a monoterpene glycoside from peony root. Phytochemistry 29:3859–3863

    Article  CAS  Google Scholar 

  • Yu HY, Liu MG, Liu DN, Shang GW, Wang Y, Qi C, Zhang KP, Song ZJ, Chen J (2007) Antinociceptive effects of systemic paeoniflorin on bee venom-induced various ‘phenotypes’ of nociception and hypersensitivity. Pharmacol Biochem Behav 88(2):131–140

    Article  PubMed  CAS  Google Scholar 

  • Yu HK, Chen Y, Sun YJ, Pan X (2008) Isolation and characterization analysis of polysaccharide from Paeonia albiflora Pall. J Biol 145(5):36–38, 73 (in Chinese)

    Google Scholar 

  • Yuk HJ, Ryu HW, Jeong SH, Curtis-Long MJ, Kim HJ, Wang Y, Song YH, Park KH (2013) Profiling of neuraminidase inhibitory polyphenols from the seeds of Paeonia lactiflora. Food Chem Toxicol 55:144–149

    Article  PubMed  CAS  Google Scholar 

  • Zeng J, Dou Y, Guo J, Wu X, Dai Y (2013) Paeoniflorin of Paeonia lactiflora prevents renal interstitial fibrosis induced by unilateral ureteral obstruction in mice. Phytomedicine 20(8–9):753–759

    Article  PubMed  CAS  Google Scholar 

  • Zhan LY, Xia ZY, Chen C, Wang XY (2006) Effect of Radix Paeoniae Rubra on the expression of HO-1 and iNOS in rats with endotoxin-induced acute lung injury. Chin J Traumatol 9(3):181–186

    PubMed  Google Scholar 

  • Zhang Y (1991) The effects of nifedipine, diltiazem, and Paeonia lactiflora Pall. on atherogenesis in rabbits. Zhonghua Xin Xue Guan Bing Za Zhi 19(2):100–103 (in Chinese)

    PubMed  CAS  Google Scholar 

  • Zhang W, Dai SM (2012) Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis. Int Immunopharmacol 14(1):27–31

    Article  PubMed  CAS  Google Scholar 

  • Zhang YZ, Yan XF (1990) Effects of nifedipine and Paeonia lactiflora on plasma TXB2 and 6-Keto-PGF1 alpha in cholesterol-fed rabbits. Zhong Xi Yi Jie He Za Zhi 10(11):669–671, 645 (in Chinese)

    PubMed  CAS  Google Scholar 

  • Zhang XY, Wang JH, Li X (2001) A study on the chemical constituents of Paeonia lactiflora Pall. J Shenyang Pharm Univ 18(1):30–32

    CAS  Google Scholar 

  • Zhang XY, Gao CK, Wang JH, Li X (2002) A new monoterpene glycoside from Paeonia lactiflora Pall. Yao Xue Xue Bao 37(9):705–708 (in Chinese)

    PubMed  CAS  Google Scholar 

  • Zhang HF, Hou P, Xiao WG (2007) Clinical observation on effect of total glucosides of paeony in treating patients with non-systemic involved Sjögren syndrome. Zhongguo Zhong Xi Yi Jie He Za Zhi 27(7):596–598 (in Chinese)

    PubMed  Google Scholar 

  • Zhang M, Zhu DZ, Li ZS, Zhan XB (2008a) Red peony root decoction in treatment of severe acute pancreatitis: a randomized controlled trial. Zhong Xi Yi Jie He Xue Bao 6(6):569–575 (in Chinese)

    Article  PubMed  Google Scholar 

  • Zhang XJ, Li Z, Leung WM, Liu L, Xu HX, Bian ZX (2008b) The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats. J Pain 9(6):497–505

    Article  PubMed  CAS  Google Scholar 

  • Zhang P, Zhang JJ, Su J, Qi XM, Wu YG, Shen JJ (2009a) Effect of total glucosides of paeony on the expression of nephrin in the kidneys from diabetic rats. Am J Chin Med 37(2):295–307

    Article  PubMed  CAS  Google Scholar 

  • Zhang XJ, Chen HL, Li Z, Zhang HQ, Xu HX, Sung JJ, Bian ZX (2009b) Analgesic effect of paeoniflorin in rats with neonatal maternal separation-induced visceral hyperalgesia is mediated through adenosine A(1) receptor by inhibiting the extracellular signal-regulated protein kinase (ERK) pathway. Pharmacol Biochem Behav 94(1):88–97

    Article  PubMed  CAS  Google Scholar 

  • Zhang HF, Xiao WG, Hou P (2011) Clinical study of total glucosides of paeony in patients with systemic lupus erythematosus. Zhongguo Zhong Xi Yi Jie He Za Zhi 31(4):476–479 (in Chinese)

    PubMed  Google Scholar 

  • Zhao YX, Liu Y (2006) Clinical observation on effects of leflunomid and total glucosides of paeony on rheumatoid arthritis. Zhongguo Zhong Xi Yi Jie He Za Zhi 26(4):355–357

    PubMed  CAS  Google Scholar 

  • Zhao D, Tao J, Han C, Ge J (2012) Flower color diversity revealed by differential expression of flavonoid biosynthetic genes and flavonoid accumulation in herbaceous peony (Paeonia lactiflora Pall.). Mol Biol Rep 39(12):11263–11275

    Article  PubMed  CAS  Google Scholar 

  • Zheng YQ, Wei W (2005) Total glucosides of paeony suppresses adjuvant arthritis in rats and intervenes cytokine-signaling between different types of synoviocytes. Int Immunopharmacol 5(10):1560–1573

    Article  PubMed  CAS  Google Scholar 

  • Zheng LL, Yan XF, Zhang YZ (1996) Effect of Paeonia lactiflora on platelet cytosolic free calcium and erythrocyte membrane Ca(2+)-Mg(2+)-ATPase activity in hyperlipid rabbits. Zhongguo Zhong Xi Yi Jie He Za Zhi 16(5):295–296 (in Chinese)

    PubMed  CAS  Google Scholar 

  • Zheng YQ, Wei W, Zhu L, Liu JX (2007) Effects and mechanisms of paeoniflorin, a bioactive glucoside from paeony root, on adjuvant arthritis in rats. Inflamm Res 56:182–188

    Article  PubMed  CAS  Google Scholar 

  • Zheng LY, Pan JQ, Lv JH (2008) Effects of total glucosides of paeony on enhancing insulin sensitivity and antagonizing nonalcoholic fatty liver in rats. Zhongguo Zhong Yao Za Zhi 33(20):2385–2390 (in Chinese)

    PubMed  Google Scholar 

  • Zhong SZ, Ge QH, Qu R, Li Q, Ma SP (2009) Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by D-galactose in ICR mice. J Neurol Sci 277(1–2):58–64

    Article  PubMed  CAS  Google Scholar 

  • Zhou Y, Wang H, Li YS, Tao YW, Zhang JY, Zhang ZQ (2010) Paeoniflorin increases beta-defensin expression and attenuates lesion in the colonic mucosa from mice with oxazolone-induced colitis. Yao Xue Xue Bao 45(1):37–42

    PubMed  CAS  Google Scholar 

  • Zhou CH, Zhang Y, Sheng Y, Zhao D, Lv S, Hu Y, Tao J (2011a) Herbaceous peony (Paeonia lactiflora Pall.) as an alternative source of oleanolic and ursolic acids. Int J Mol Sci 12(1):655–667

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Zhou H, Bian D, Jiao X, Wei Z, Zhang H, Xia Y, He Y, Dai Y (2011b) Paeoniflorin protects against lipopolysaccharide-induced acute lung injury in mice by alleviating inflammatory cell infiltration and microvascular permeability. Inflamm Res 60(10):981–990

    Article  PubMed  CAS  Google Scholar 

  • Zhou Z, Lin J, Huo R, Huang W, Zhang J, Wang L, Sun Y, Shen B, Li N (2012) Total glucosides of paeony attenuated functional maturation of dendritic cells via blocking TLR4/5 signaling in vivo. Int Immunopharmacol 14(3):275–282

    Article  PubMed  CAS  Google Scholar 

  • Zhu L, Wei W, Zheng YQ, Jia XY (2005) Effects and mechanisms of total glucosides of paeony on joint damage in rat collagen-induced arthritis. Inflamm Res 54(5):211–220

    Article  PubMed  CAS  Google Scholar 

  • Zhu L, Wei W, Zheng YQ (2006) Effect and mechanism of action of total glucosides of paeony on synoviocytes from rats with collagen-induced arthritis. Yao Xue Xue Bao 41(2):166–170 (in Chinese)

    PubMed  Google Scholar 

  • Zhu Y, Dang S, Hua Z (2010) Advanced achievements about neuroprotective mechanisms of paeoniflorin. Zhongguo Zhong Yao Za Zhi 35(11):1490–1493 (in Chinese)

    PubMed  CAS  Google Scholar 

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  1. Canberra, Aust Capital Terr, Australia

    T. K. Lim

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Lim, T.K. (2014). Paeonia lactiflora. In: Edible Medicinal and Non Medicinal Plants. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8748-2_44

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