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Nanomaterial pp 157–182Cite as

Design, Synthesis, and Functionalization of Nanomaterials for Therapeutic Drug Delivery

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 811))

Abstract

Nanomaterials have the potential to solve some of the toughest challenges facing modern medicine. Their unique optical, magnetic and chemical properties at the nanoscale make them different from their macroscale counterparts. Successful application of nanomaterials can revolutionize therapeutics, diagnostics and imaging in several biomedical applications. Self-assembled amphiphilic polymeric nanoparticles have been employed to carry poorly soluble chemotherapeutic drugs. Loading of anticancer chemotherapeutic drugs into self assembled polymeric nanoparticles have shown to increase their circulation time, tumor localization and therapeutic potential. This book chapter provides an introductory discussion to organic nanotechnologies for drug delivery. Promising advances in the field of nanomedicine will be discussed and an outlook to the future will be provided.

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Abbreviations

mL:

Milliliters

nm:

Nanometer

NP:

Nanoparticle

PEG:

Poly (ethyleneglycol)

QD:

Quantum Dots

μL:

Microliters

μm:

Micrometer

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Acknowledgements

This work has been supported by the National Science Foundation (NSF grants CBET-0829128 and CBET-1067840). The authors thank Dr. Bhavani Miryala, Ms. Amrita Mallik, Mr. James Ramos, and Mr. Karthik Pushpavanam in the Molecular and Nanoscale Bioengineering (Rege) laboratory for several useful discussions.

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Authors and Affiliations

  1. Biomedical Engineering, School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA

    Taraka Sai Pavan Grandhi

  2. Biomedical Engineering, School of Biological and Health Systems Engineering, Tempe, AZ, USA

    Kaushal Rege

  3. Chemical Engineering, School of Engineering of Matter, Transport and Energy, Arizona State University, Tempe, AZ, 85287, USA

    Kaushal Rege

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  1. Taraka Sai Pavan Grandhi
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Correspondence to Kaushal Rege .

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  1. Arizona State University, Tempe, Arizona, USA

    David G. Capco

  2. Georgia Institute of Technology, Atlanta, Georgia, USA

    Yongsheng Chen

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Grandhi, T.S.P., Rege, K. (2014). Design, Synthesis, and Functionalization of Nanomaterials for Therapeutic Drug Delivery. In: Capco, D., Chen, Y. (eds) Nanomaterial. Advances in Experimental Medicine and Biology, vol 811. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8739-0_9

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