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Nanomaterial pp 45–54Cite as

Influences of Nanomaterials on the Barrier Function of Epithelial Cells

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 811))

Abstract

Recent advances in nanotechnology have led to exciting opportunities in medicine, energy, manufacturing, and other fields. Nevertheless, it is important to adequately assess the potential impacts of nanomaterial exposure. This chapter focuses on the interactions of nanomaterials with epithelial barriers in the lungs, intestine, kidneys, skin, and placenta. Methods for determining transepithelial electrical resistance and paracellular permeability are described. Effects on cell viability and barrier integrity depend on the chemical nature of the nanomaterial, nanoparticle size, surface coatings, and concentration. Disruption of tight junctions can affect permeability and interfere with normal regulatory processes of the epithelial barrier. Future research is needed to better understand the possibilities and the limits of novel approaches in nanotechnology.

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Acknowledgment

Research support from the John Sealy Memorial Endowment Fund for Biomedical Research is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555-0587, USA

    Shariq Ali & Erik Rytting

Authors
  1. Shariq Ali
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  2. Erik Rytting
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Corresponding author

Correspondence to Erik Rytting .

Editor information

Editors and Affiliations

  1. Arizona State University, Tempe, Arizona, USA

    David G. Capco

  2. Georgia Institute of Technology, Atlanta, Georgia, USA

    Yongsheng Chen

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Ali, S., Rytting, E. (2014). Influences of Nanomaterials on the Barrier Function of Epithelial Cells. In: Capco, D., Chen, Y. (eds) Nanomaterial. Advances in Experimental Medicine and Biology, vol 811. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8739-0_3

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