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Risk Exposure: Using Cases in Strategies Involving an Aging Medication

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Developing a Virtue-Imbued Casuistry for Business Ethics

Part of the book series: Issues in Business Ethics ((IBET,volume 42))

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Abstract

Explains the history of a controversial and aging breast cancer preventative drug called tamoxifen, the risk assessment processes used to determine whether or not to continue to aggressively market a medication that remains beneficial to some but not all, the risks associated with moral lacunae, and how virtue-imbued casuistry can fortify current risk analysis processes.

It is better by noble boldness to run the risk of being subject to half the evils we anticipate than to remain in cowardly listlessness for fear of what might happen. (Herodotus 1890).

—Herodotus

The quote here is a summary of the following: It is better to have good courage about everything and to suffer half the evils which threaten, than to have fear beforehand about everything and not to suffer any evil at all: and if, while contendingagainst everything which is said, thou omit to declare the course which is safe, thou dost incur in these matters the reproach of failure equally with him who says the opposite to this. This then, I say, is evenly balanced: but how should one who is but man know the course which is safe? I think, in no way. To those then who choose to act, for the most part gain is wont to come; but to those who reckon for everything andshrink back, it is not much wont to come.

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Notes

  1. 1.

    In April 2013, American celebrity and actress Angelina Jolie had a preventative double mastectomy based on an 87 % risk of breast cancer and a family history of the disease. She reports that now her chances of developing breast cancer have dropped to under 5 % (Jolie 2013).

  2. 2.

    Online sources typically appeal to the claim that, “In 1992 the Lancet published a review of a number of studies in which a total of 30,000 breast cancer patients were randomly assigned either to take tamoxifen or not. The average patient in this collaborative study was followed up for between five and six years. Of the patients taking tamoxifen, 74.4 per cent survived, as compared with 70.9 per cent in the non-tamoxifen group—a less than impressive improvement than was declared at the time the drug passed the clinical trials.” In addition, they point to claims that “Despite tamoxifen’s proven ability to reduce breast cancer recurrence in post-menopausal women, major studies have shown that tamoxifen reduces death from breast cancer only marginally . The majority of women who take tamoxifen live no longer than women who do not take it” (Sellman 1998).

  3. 3.

    (Breast International Group (BIG) 1–98 Collaborative Group et al. 2005; Taras et al. 2000; Young 2007). A large international trial of postmenopausal women surgically treated for early-stage, hormone responsive breast cancer found that letrozole (Femara®) did better to prevent a recurrence of disease (especially distant metastases) than the commonly prescribed tamoxifen (Nolvadex®) (Coates et al. 2007).

  4. 4.

    It should be mentioned that some bodybuilders use tamoxifen illicitly to thwart the gynecomastia (bitch tits) that results from overusing androgenic anabolic steroids .

  5. 5.

    My thanks to Mark Sioma for assistance in framing the profit/risk example here.

  6. 6.

    For more on ethical blind spots , see (Moberg 2006).

  7. 7.

    See (Bernalillo County 1994). For commentary on the case, see (Cain 2007; Ramseyer and Rasmusen 2010).

  8. 8.

    It should be noted that there is disagreement over whether true cases must be based solely on firsthand experience.

  9. 9.

    My thanks to Society for Business Ethics 2013 Conference reviewer #1 for his or her helpful insights about some of the features of this chapter.

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Correspondence to Martin Calkins .

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Calkins, M. (2014). Risk Exposure: Using Cases in Strategies Involving an Aging Medication. In: Developing a Virtue-Imbued Casuistry for Business Ethics. Issues in Business Ethics, vol 42. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8724-6_15

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