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Population Immunology: Germs, Aging and Inflammation

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Eco-immunology

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Abstract

Immunosenescence has been described as a combination of dysfunctional immunity with a state of low grade chronic inflammation (inflammaging) in the elderly. These processes may result either in increased susceptibility to infections or in the development of chronic inflammatory diseases and frailty in the elderly. However, not all elderly bear a dysfunctional immunity. Senescence may also be accompanied by a remodeling of the immune system that is associated with increased longevity and healthy aging. The concept of healthy aging has been proposed initially in Europe to describe the individuals who reach advanced age free of inflammatory consequences of immunosenescence. Since then, the quest for biological markers of healthy aging has been focused on the consequences of inflammaging, but this inflammatory status might be a deleterious event restricted to populations living in clean environments. In other parts of the world where infectious diseases are still prevalent, inflammatory responses may be beneficial and needed to cope with infections agents. Therefore, the debate over the biological markers of healthy aging would have to take into account geographical, cultural and environmental differences that reflect the changes in the past century in our contacts with microorganisms and their immunological consequences.

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References

  • Akbar AN, Fletcher JM (2005) Memory T cell homeostasis and senescence during aging. Curr Opin Immunol 17:480–485

    Article  CAS  Google Scholar 

  • Amaral JF, Foschetti DA, Assis FA, Menezes JS, Vaz NM, Faria AM (2006) Immunoglobulin production is impaired in protein-deprived mice and can be restored by dietary protein supplementation. Braz J Med Biol Res 39(12):1581–1586

    Article  PubMed  CAS  Google Scholar 

  • Amaral JF, Gomes-Santos AC, Paula-Silva J, Nicoli JR, Vieira LQ, Faria AM, Menezes JS (2009) Antigenic dietary protein guides maturation of the host immune system promoting resistance to Leishmania major infection in C57BL/6 mice. Immunology 129(3):455–464

    Article  PubMed  Google Scholar 

  • Andreasen CH, Stender-Petersen KL, Mogensen MS, Torekov SS, Wegner L, Andersen G, Nielsen AL, Albrechtsen A, Borch-Johnsen K, Rasmussen SS, Clausen JO, Sandbaek A, Lauritzen T, Hansen L, Jørgensen T, Pedersen O, Hansen T (2008) Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 57(1):95–101

    Article  PubMed  CAS  Google Scholar 

  • Andrews ZB, Horvath TL (2009) Uncoupling protein-2 regulates lifespan in mice. Am J Physiol Endocrinol Metab 296(4):E621–627

    Google Scholar 

  • Araújo MI, Hoppe BS, Medeiros M Jr, Carvalho EM (2004) Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases. Mem Inst Oswaldo Cruz 99(5 Suppl 1):27–32

    Article  PubMed  Google Scholar 

  • Bethony J, Williams J, Blangero J et al (2002) Additive host genetic factors influence fecal egg excretion rates during Schistosoma mansoni infection in a rural area in Brazil. Am J Trop Med Hyg 67:336–343

    PubMed  CAS  Google Scholar 

  • Biagi E, Nylund L, Candela M, Ostan R, Bucci L, Pini E, Nikkïla J, Monti D, Satokari R, Franceschi C, Brigidi P, De Vos W (2010) Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One 5(5):e10667

    Article  PubMed Central  PubMed  Google Scholar 

  • Candela M, Maccaferri S, Turroni S, Carnevali P, Brigidi P (2010) Functional intestinal microbiome, new frontiers in prebiotic design. Int J Food Microbiol 140(2–3):93–101

    Article  PubMed  CAS  Google Scholar 

  • Carrieri G, Marzi E, Olivieri F, Marchegiani F, Cavallone L, Cardelli M, Giovagnetti S, Stecconi R, Molendini C, Trapassi C, De Benedictis G, Kletsas D, Franceschi C (2004) The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians. Aging Cell 3(6):443–448

    Article  PubMed  CAS  Google Scholar 

  • Coombes JL, Siddiqui KR, Arancibia-Cárcamo CV, Hall J, Sun CM, Belkaid Y, Powrie F (2007) A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 204(8):1757–1764

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Comin F, Speziali E, Martins-Filho OA, Caldas IR, Moura V, Gazzinelli A, Correa-Oliveira R, Faria AM (2007) Ageing and Toll-like receptor expression by innate immune cells in chronic human schistosomiasis. Clin Exp Immunol 149(2):274–284

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Comin F, Speziali E, Correa-Oliveira R, Faria AM (2008) Aging and immune response in chronic human schistosomiasis. Acta Trop 108(2–3):124–130

    Article  PubMed  CAS  Google Scholar 

  • Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261(5123):921–923

    Article  PubMed  CAS  Google Scholar 

  • Cossarizza A, Ortolani C, Monti D, Franceschi C (1997) Cytometric analysis of immunosenescence. Cytometry 27:297–313

    Article  CAS  Google Scholar 

  • Dato S, Carotenuto L, De Benedictis G (2007) Genes and longevity: a genetic-demographic approach reveals sex- and age-specific gene effects not shown by the case-control approach (APOE and HSP70.1 loci). Biogerontology 8:31–41

    Article  PubMed  CAS  Google Scholar 

  • Daynes RA, Araneo BA, Ershler WB, Maloney C, Li GZ, Ryu SY (1993) Altered regulation of IL-6 production with normal aging. Possible linkage to the age associated decline in dehydroepiandrosterone and its sulfated derivative. J Immunol 150:5219–5230. Miller, 1996

    Google Scholar 

  • De Benedictis G, Franceschi C (2009) The unusual genetics of human longevity. Sic Aging Knowledge Environ 2006:20

    Google Scholar 

  • Duchmann R, Neurath MF, Meyer zum Büschenfelde KH (1997) Responses to self and non-self intestinal microflora in health and inflammatory bowel disease. Res Immunol 148(8–9):589–594

    Article  PubMed  CAS  Google Scholar 

  • El Sharawy A, Keller A, Flachsbart F, Wendschlag A, Jacobs G, Kefer N, Brefort T, Leidinger P, Backes C, Meese E, Schreiber S, Rosenstiel P, Franke A, Nebel A (2012) Genome-wide miRNA signatures of human longevity. Ageing Cell 11(4):607–616

    Article  CAS  Google Scholar 

  • Faria AM, Ficker SM, Speziali E, Menezes JS, Stransky B, Silva Rodrigues V, Vaz NM (1998) Aging affects oral tolerance induction but not its maintenance in mice. Mech Ageing Dev 102(1):67–80

    Article  PubMed  Google Scholar 

  • Faria AM, Maron R, Ficker SM, Slavin AJ, Spahn T, Weiner HL (2003) Oral tolerance induced by continuous feeding: enhanced up-regulation of transforming growth factor-beta/interleukin-10 and suppression of experimental autoimmune encephalomyelitis. J Autoimmun 20(2):135–145

    Article  PubMed  CAS  Google Scholar 

  • Faria, AM, Weiner, HL (2005) Oral tolerance. Immunol Rev 206:232–259

    Article  PubMed  CAS  Google Scholar 

  • Faria AM, Weiner HL (2006) Oral tolerance and TGF-beta-producing cells. Inflamm Allergy Drug Targets 5(3):179–190

    Article  PubMed  CAS  Google Scholar 

  • Franceschi C, Valensin S, Bonafe M, Paolisso G, Yashin AI, Monti D, De Benedictis G (2000) The network and the remodeling theories of aging: historical background and new perspectives. Exp Gerontol 35:879–896

    Article  PubMed  CAS  Google Scholar 

  • Franceschi C, Bonafe` M (2003) Centenarians as a model for healthy aging. Biochem Soc Transact 31:457–461

    Article  CAS  Google Scholar 

  • Franceschi C, Bezrukov V, Blanché H, Bolund L, Christensen K, de Benedictis G, Deiana L, Gonos E, Hervonen A, Yang H, Jeune B, Kirkwood TB, Kristensen P, Leon A, Pelicci PG, Peltonen L, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Sikora E, Slagboom PE, Spazzafumo L, Stazi MA, Toussaint O, Vaupel JW (2007) Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging). Ann N Y Acad Sci 1100:21–45

    Article  PubMed  CAS  Google Scholar 

  • Frank DN, Pace NR (2008) Gastrointestinal microbiology enters the metagenomics era. Curr Opin Gastroenterol 24(1):4–10

    Article  PubMed  CAS  Google Scholar 

  • Frei R, Lauener RP, Crameri R, O’Mahony L (2012) Microbiota and dietary interactions: an update to the hygiene hypothesis? Allergy 67(4):451–461

    Article  PubMed  CAS  Google Scholar 

  • Fries JF (2000) Compression of morbidity in the elderly. Vaccine 18:1584–1589

    Article  PubMed  CAS  Google Scholar 

  • Gazzinelli G, Bethony J, Alves Fraga L, LoVerde PT, Correa-Oliveira R, Kloos H (2001) Exposure to Schistosoma mansoni infection in a rural area of Brazil. I. Water contact. Trop Med Int Health 6:126–135

    Article  PubMed  CAS  Google Scholar 

  • Gazzinelli A, Correa-Oliveira R, Yang GJ, Boatin BA, Kloos H (2012) A research agenda for helminth diseases of humans: social ecology, environmental determinants, and health systems. PLoS Negl Trop Dis 6(4):e1603

    Article  PubMed Central  PubMed  Google Scholar 

  • Ginaldi L, De Martinis M, Monti D, Franceschi C (2005) Chronic antigenic load and apoptosis in immunosenescence. Trends Immunol 26(2):79–84

    Article  PubMed  CAS  Google Scholar 

  • Gravina S, Lescai F, Hurteau G, Brock GJ, Saramaki A, Salvioli S, Franceschi C, Roninson IB. (2009) Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population. Aging 1(5):470–480

    PubMed Central  PubMed  CAS  Google Scholar 

  • Guarente L, Picard F (2005) Calorie restriction–the SIR2 connection. Cell 120(4):473–82

    Article  PubMed  CAS  Google Scholar 

  • Hansson J, Bosco N, Favre L, Raymond F, Oliveira M, Metairon S, Mansourian R, Blum S, Kussmann M, Benyacoub J (2011) Influence of gut microbiota on mouse B2 B cell ontogeny and function. Mol Immunol 48(9–10):1091–1101

    Article  PubMed  CAS  Google Scholar 

  • Harman D (1972) The biologic clock: the mitochondria? J Am Geriatr Soc 20:145–147

    PubMed  CAS  Google Scholar 

  • He Y, Li J, Zhuang W, Yin L, Chen C, Li J, Chi F, Bai Y, Chen XP (2010) The inhibitory effect against collagen-induced arthritis by Schistosoma japonicum infection is infection stage-dependent. BMC Immunol 11:28

    Article  PubMed Central  PubMed  Google Scholar 

  • Hodes RJ (1995) Molecular alterations in the aging immune system. J Exp Med 182:1–3

    Article  PubMed  CAS  Google Scholar 

  • International Food Policy Research Institute (2010) Study finds Bolsa Familia children healthier, doing better in school (press release). http://www.ifpri.org/sites/default/files/20100810pressrel.pdf

  • Izcue A, Coombes JL, Powrie F (2006) Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol Rev 212:256–271

    Article  PubMed  CAS  Google Scholar 

  • Keller L, Xu W, Wang HX, Winblad B, Fratiglioni L, Graff C (2011) The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer’s disease risk: a prospective cohort study. J Alzheimers Dis 23(3):461–469

    PubMed  CAS  Google Scholar 

  • Kujoth GC, Bradshaw PC, Haroon S, Prolla TA (2007) The role of mitochondrial DNA mutations in mammalian aging. PLoS Genet 3:e24

    Article  PubMed Central  PubMed  Google Scholar 

  • Lescai F, Blanché H, Nebel A, Beekman M, Sahbatou M, Flachsbart F, Slagboom E, Schreiber S, Sorbi S, Passarino G, Franceschi C (2009) Human longevity and 11p15.5: a study in 1321 centenarians. Eur J Hum Gen 17:1515–1519

    Article  Google Scholar 

  • Ligthart GJ, Corberand JX, Fournier C, Galanaud P, Hijmans W, Kennes B, Muller-Hermelink HK, Steinmann GG (1984) Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech Age Dev 28:47–55

    Article  CAS  Google Scholar 

  • Malaguarnera L, Ferlito L, Imbesi RM, Gulizia GS, Di Mauro S, Maugeri D, Malaguarnera M, Messina A (2001) Immunosenescence: a review. Arch Gerontol Geriatr 32:1–14

    Google Scholar 

  • Martinis M, Franceschi C, Monti D, Ginaldi L (2005) Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett 579(10):2035–2039

    Article  PubMed  Google Scholar 

  • Menezes JS, Mucida DS, Cara DC, Alvarez-Leite JI, Russo M, Vaz NM, de Faria AM (2003) Stimulation by food proteins plays a critical role in the maturation of the immune system. Int Immunol 15(3):447–455

    Article  PubMed  CAS  Google Scholar 

  • Mestecky J, Russell MW, Elson CO (2007) Perspectives on mucosal vaccines: is mucosal tolerance a barrier? J Immunol 179(9):5633–5638

    Article  PubMed  CAS  Google Scholar 

  • Michikawa Y, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G (1999) Aging dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 286:774–779

    Article  PubMed  CAS  Google Scholar 

  • Min CK, Maeda Y, Lowler K, Liu C, Clouthier S, Lofthus D, Weisiger E, Ferrara JL, Reddy P (2004) Paradoxical effects of interleukin-18 on the severity of acute graft-versus-host disease mediated by CD4+ and CD8+ T-cell subsets after experimental allogeneic bone marrow transplantation. Blood 2004 Nov 15 104(10):3393–3399

    Article  PubMed  CAS  Google Scholar 

  • Moreau MC, Raibaud P, Muller MC (1982) Relationship between the development of the intestinal IgA immune system and the establishment of microbial flora in the digestive tract of young holoxenic mice. Ann Immunol (Paris) 133D(1):29–39

    Google Scholar 

  • Moreels TG, Nieuwendijk RJ, De Man JG, De Winter BY, Herman AG, Van Marck EA, Pelckmans PA (2004) Concurrent infection with Schistosoma mansoni attenuates inflammation induced changes in colonic morphology, cytokine levels, and smooth muscle contractility of trinitrobenzene sulphonic acid induced colitis in rats. Gut 53(1):99–107

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, Cheroutre H (2007) Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317(5835):256–260

    Article  PubMed  CAS  Google Scholar 

  • Mutapi F, Imai N, Nausch N, Bourke CD, Rujeni N, Mitchell KM, Midzi N, Woolhouse ME, Maizels RM, Mduluza T (2011) Schistosome infection intensity is inversely related to auto-reactive antibody levels. PLoS One 6(5):e19149

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Neish AS (2009) Microbes in gastrointestinal health and disease. Gastroenterology 136(1):65–80

    Article  PubMed Central  PubMed  Google Scholar 

  • Njemini R, Abeele MV, Demanet C, Lambert M, Vandebosch S, Mets T (2003) Age-related decrease in the inducibility of heat-shock protein 70 in human peripheral blood mononuclear cells. J Clin Immunol 22(4):195–205

    Article  Google Scholar 

  • Olivieri O, Martinelli N, Bassi A, Trabetti E, Girelli D, Pizzolo F, Friso S, Pignatti PF, Corrocher R (2007) ApoE epsilon2/epsilon3/epsilon4 polymorphism, ApoC-III/ApoE ratio and metabolic syndrome. Clin Exp Med 7(4):164–172

    Article  PubMed  CAS  Google Scholar 

  • Osada Y, Kanazawa T (2011) Schistosome: its benefit and harm in patients suffering from concomitant diseases. J Biomed Biotechnol 2011:264173

    Google Scholar 

  • Ottaviani E, Ventura N, Mandrioli M, Candela M, Franchini A, Franceschi C (2011) Gut microbiota as a candidate for lifespan extension: an ecological/evolutionary perspective targeted on living organisms as metaorganisms. Biogerontology 12(6):599–609

    Article  PubMed  CAS  Google Scholar 

  • Pawelec G, Solana R (2001) Immunoageing—the cause or effect of morbidity. Trends Immunol 22:348–349

    Article  CAS  Google Scholar 

  • Pawelec G, Solana R, Remarque E, Mariani E (1998) Impact of aging on innate immunity. J Leukoc Biol 64:703–712

    CAS  Google Scholar 

  • Perls T, Kunkel LM, Puca AA. (2002) The genetics of exceptional human longevity. J Mol Neurol 19:233–238

    Article  CAS  Google Scholar 

  • Rajilić-Stojanović M, Heilig HG, Molenaar D, Kajander K, Surakka A, Smidt H, de Vos WM (2009) Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults. Environ Microbiol 11(7):1736–1751

    Article  PubMed Central  PubMed  Google Scholar 

  • Rao DV, Watson K, Jones GL (1999) Age-related attenuation in the expression of the major heat shock proteins in human peripheral lymphocytes. Mech Ageing Dev 107(1):105–118

    Article  PubMed  CAS  Google Scholar 

  • Rook GA (2012) Hygiene hypothesis and autoimmune diseases. Clin Rev Allergy Immunol 42(1):5–15

    Article  PubMed  CAS  Google Scholar 

  • Rose G, Romeo G, Dato S, Crocco P, Bruni AC, Hervonen A, Majamaa K, Sevini F, Franceschi C, Passarino G, the GEHA Project Consortium (2010) Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA study. PlosOne 5(10):e13395

    Article  Google Scholar 

  • Rosenberg T (2011) To beat back poverty, pay the poor. New York Times. http://opinionator.blogs.nytimes.com/2011/01/03/to-beat-backpoverty-pay-the-poor/

  • Sansoni P, Cossarizza A, Brianti V, Fagnoni F, Snelli G, Monti D, Marcato A, Passeri G, Ortolani C, Forti E et al (1993) Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians. Blood 82:2767–2773

    CAS  Google Scholar 

  • Sansoni P, Vescovini R, Fagnoni F, Biasini C, Zanni F, Zanlari L, Telera A, Lucchini G, Passeri G, Monti D, Franceschi C, Passeri M. (2008) The immune system in extreme longevity. Exp Gerontol 2008 Feb 43(2):61–65

    Article  PubMed  CAS  Google Scholar 

  • Schächter F, Faure-Delanef L, Guénot F, Rouger H, Froguel P, Lesueur-Ginot L, Cohen D (1994) Genetic associations with human longevity at the APOE and ACE loci. Nat Genet 6(1):29–32

    Article  PubMed  Google Scholar 

  • Sheldon WG, Bucci TJ, Hart RW, Turturro A (1995) Age-related neoplasia in a lifetime study of ad libitum-fed and food-restricted B6C3F1 mice. Toxicol Pathol 23(4):458–476

    Article  PubMed  CAS  Google Scholar 

  • Solana R, Alonso MC, Pena J (1999) Natural killer cells in healthy aging. Exp Gerontol 34:435–443

    Google Scholar 

  • Solana R, Mariani E (2000) NK and NK/T cells in human senescence. Vaccine 18:1613–1620

    Article  CAS  Google Scholar 

  • Speziali E, Bethony J, Martins-Filho O, Fraga LA, Lemos DS, Souza LJ, Correa-Oliveira R, Faria AM (2004) Production of interferon-gamma by natural killer cells and aging in chronic human schistosomiasis.Mediat. Inflamm 13:327–333

    CAS  Google Scholar 

  • Strachan DP (2000) The role of environmental factors in asthma. Br Med Bull 56(4):865–882

    Article  PubMed  CAS  Google Scholar 

  • Trifunovic A, Larsson NG (2008) Mitochondrial dysfunction as a cause of ageing. J Intern Med 263:167–178

    Article  PubMed  CAS  Google Scholar 

  • Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI (2007) The human microbiome project. Nature 449(7164):804–810

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Vasto S, Mocchegiani E, Malavolta M, Cuppari I, Listì F, Nuzzo D, Ditta V, Candore G, Caruso C (2007) Zinc and inflammatory/immune response in aging. Ann N Y Acad Sci 1100:111–122

    Article  PubMed  CAS  Google Scholar 

  • Vinolo MA, Rodrigues HG, Nachbar RT, Curi R (2011) Regulation of inflammation by short chain fatty acids. Nutrients 3(10):858–876

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Wang Y, Michikawa Y, Mallidis C, Bai Y, Woodhouse L et al (2001) Musclespecific mutations accumulate with aging in critical human mtDNA control sites for replication. Proc Natl Acad Sci USA 98:4022–4027

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Webster M, Roberts M, Fulford AJ et al (1998). Human IgE responses to rSm22.6 are associated with infection intensity rather than age per se, in a recently established focus of Schistosoma mansoni. Trop Med Int Health 3:318–326

    Article  PubMed  CAS  Google Scholar 

  • Weng NP (2006) Aging of the immune system: howmuch can the adaptive immune system adapt? Immunity 24:495–499

    Article  CAS  Google Scholar 

  • Wong CP, Ho E (2012) Zinc and its role in age-related inflammation and immune dysfunction. Mol Nutr Food Res 56(1):77–87

    Article  PubMed  CAS  Google Scholar 

  • Wood KL, Twigg HL 3rd, Doseff AI (2009) Dysregulation of CD8+ lymphocyte apoptosis, chronic disease, and immune regulation. Front Biosci 14:3771–3781

    Article  CAS  Google Scholar 

  • World Health Organization (2007) Global plan to combat neglected tropical diseases 2008–2015. Geneva: World Health Organization. 40 p

    Google Scholar 

  • Yang J, Zhao J, Yang Y, Zhang L, Yang X, Zhu X, Ji M, Sun N, Su C (2007) Schistosoma japonicum egg antigens stimulate CD4 CD25 T cells and modulate airway inflammation in a murine model of asthma. Immunology 120(1):8–18

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Zaccone P, Burton O, Miller N, Jones FM, Dunne DW, Cooke A (2009) Schistosoma mansoni egg antigens induce Treg that participate in diabetes prevention in NOD mice. Eur J Immunol 39(4):1098–1107

    Article  PubMed  CAS  Google Scholar 

  • Zheng X, Hu X, Zhou G, Lu Z, Qiu W, Bao J, Dai Y (2008) Soluble egg antigen from Schistosoma japonicum modulates the progression of chronic progressive experimental autoimmune encephalomyelitis via Th2-shift response. J Neuroimmunol 194(1–2):107–114

    Article  PubMed  CAS  Google Scholar 

  • Zimmermann E, Kring SII, Berentzen TL, Holst C, Pers TH, Hansen T, Pedersen O, Sørensen TIA, Jess T (2009) Fatness-Associated FTO Gene variant increases mortality independent of fatness—in cohorts of Danish men. PLoS ONE 4(2):e4428

    Article  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Departamento de Bioquimica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

    Ana Maria C. Faria

  2. Department of Experimental, Diagnostic and Specialty medicine, University of Bologna, Via S. Giacomo 12, Bologna, Italy

    Claudio Franceschi

  3. Interdepartmental Centre “Galvani”, University of Bologna, Via Selmi 3, Bologna, Italy

    Claudio Franceschi

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  1. Ana Maria C. Faria
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Correspondence to Claudio Franceschi .

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  1. University of Modena and Reggio Emilia, Modena, Italy

    Davide Malagoli

  2. University of Modena and Reggio Emilia, Modena, Italy

    Enzo Ottaviani

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Faria, A., Franceschi, C. (2014). Population Immunology: Germs, Aging and Inflammation. In: Malagoli, D., Ottaviani, E. (eds) Eco-immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8712-3_8

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