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Endothelial Progenitor Cells Derived from Cord or Peripheral Blood and Their Potential for Regenerative Therapies

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Adult and Pluripotent Stem Cells

Abstract

Cell therapies using stem/progenitor cells hold enormous promise for a wide range of serious and hitherto untreatable diseases. Peripheral blood as well as umbilical cord blood have been demonstrated to be ideal sources of stem/progenitor cells differentiating into endothelial-like cells with high proliferative capacities and the capability to incorporate into hypoxic tissue areas as they occur in ischemic cardiomyopathies. These findings have led to the concept that postnatal vasculogenesis does occur and that neovascularisation in the adult is not solely achieved by sprouting from preexisting mature endothelial cells. In any case, irrespective of the debated origin and normal physiological role of these cells, this opened a new field in tissue regeneration as the cells can be used to trigger neovascularization and the restored supply of oxygen and nutrients is a necessary precondition for the regeneration of any damaged tissue. We will therefore here discuss the occurrence, development and therapeutic potential of postnatal vascular stem and progenitor cells from blood. This will include aspects of our recent work identifying factors characterizing and distinguishing blood-derived endothelial progenitor cells from mature endothelial cells of the vessel wall.

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Abbreviations

HSC:

Hematopoietic stem cell

EPC:

Endothelial progenitor cell

CEC:

Circulating endothelial cell

ECFC:

Endothelial colony forming cell

BOEC:

Blood outgrowth endothelial cell

HUVEC:

Human umbilical vein endothelial cells

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Acknowledgements

This work was supported by grants of the European Commission (Health-F2-2009-222995, INELPY/Infarct Cell Therapy), the Austrian Science Fund (FWF P-21291-B11) and the Research Studio Austria Programme of the FFG (FFG/RSA 832042).

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Authors and Affiliations

  1. Department of Vascular Biology and Thrombosis Research, Center of Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090, Vienna, Austria

    Renate Hofer-Warbinek, Caterina Sturtzel & Erhard Hofer

  2. Institut für morphologische Analytik und Humangenetik, Graz, Austria

    Karl-Heinz Preisegger

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  1. Renate Hofer-Warbinek
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  2. Caterina Sturtzel
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  3. Karl-Heinz Preisegger
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  4. Erhard Hofer
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Correspondence to Renate Hofer-Warbinek .

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Editors and Affiliations

  1. University of Cologne, Germany

    Jürgen Hescheler

  2. Medical University of Vienna, Austria

    Erhard Hofer

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Hofer-Warbinek, R., Sturtzel, C., Preisegger, KH., Hofer, E. (2014). Endothelial Progenitor Cells Derived from Cord or Peripheral Blood and Their Potential for Regenerative Therapies. In: Hescheler, J., Hofer, E. (eds) Adult and Pluripotent Stem Cells. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8657-7_3

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