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Chinese Burn Surgery pp 7–29Cite as

The Alterations of Microcirculation in Burns

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Abstract

The increase in the vascular permeability is the most important pathological event in the pathogenesis of a burn injury. A massive leakage of fluid from the vascular space leads to a loss of blood plasma and a decrease in the effective circulatory blood volume, resulting in the formation of severe tissue edema, hypotension or even shock in a severe burn injury [1]. Fluid resuscitation has been the only valid method of sustaining a burn patient’s blood pressure for a long time owing to the lack of an overall and profound understanding of the mechanisms of a burn-induced vascular hyperpermeability response.

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Acknowledgment

This work was supported by several sources: Chinese National Natural Scientific Foundation grant 30028008, 30771028 and 30971201; National Key Foundation for Basic Science Research of China (grant G2005CB522601); Natural Science Foundation of Guangdong, China (grant 4020373).

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  1. Department of Physiopathology, Nan Fang Hospital, Southern Medical University, Guangzhou, People’s Republic of China

    Keseng Zhao (Professor) & Qiaobing Huang (Professor)

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  1. Keseng Zhao
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  1. Third Military Medical University, Chongqing, Chong Qing, China

    Zongcheng Yang

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Zhao, K., Huang, Q. (2015). The Alterations of Microcirculation in Burns. In: Yang, Z. (eds) Chinese Burn Surgery. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8575-4_2

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  • DOI: https://doi.org/10.1007/978-94-017-8575-4_2

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