• Domenico RibattiEmail author


Angiogenesis is the main process by means of which tumors create their own oxygen and nutrient supply and a route for systemic metastasis. The role of angiogenesis in the growth and survival of haematological malignancies has become evident since 1994, when it was reported for the first time increased microvascular density (MVD) within the bone marrow of multiple myeloma (MM) versus monoclonal gammopathy of undetermined significance (MGUS) and in active (diagnosis, relapse, leukemic phase) versus non active (complete/objective response, plateau) MM. Since 1994, several evidence have been accumulated confirming the role of angiogenesis in haematological tumors.


Angiogenesis Tumor growth Tumor progression Metastasis Solid tumors Hematological tumors. 

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Department of Basic Medical Sciences, Neurosciences and Sensory OrgansUniversity of Bari Medical SchoolBariItaly

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