Abstract
Angiogenesis is the main process by means of which tumors create their own oxygen and nutrient supply and a route for systemic metastasis. The role of angiogenesis in the growth and survival of haematological malignancies has become evident since 1994, when it was reported for the first time increased microvascular density (MVD) within the bone marrow of multiple myeloma (MM) versus monoclonal gammopathy of undetermined significance (MGUS) and in active (diagnosis, relapse, leukemic phase) versus non active (complete/objective response, plateau) MM. Since 1994, several evidence have been accumulated confirming the role of angiogenesis in haematological tumors.
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© 2014 Springer Science+Business Media Dordrecht
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Ribatti, D. (2014). Introduction. In: Angiogenesis and Anti-Angiogenesis in Hematological Malignancies. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8035-3_1
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DOI: https://doi.org/10.1007/978-94-017-8035-3_1
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Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-017-8034-6
Online ISBN: 978-94-017-8035-3
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