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Notch Signaling in Differentiation and Function of Dendritic Cells

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Stem Cells and Cancer Stem Cells, Volume 12

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 12))

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Abstract

Hematopoietic stem cells give rise to multiple lineages of mature cells. This process is governed by a tightly controlled signaling network, regulated by cytokines and the direct interaction between progenitor cells and bone marrow stroma. Notch signaling represents one of the major pathways activated during the direct interaction between hematopoietic progenitor cells and bone marrow stroma. In this review, we discuss the recent findings that shed light on the critical role of Notch in the differentiation and function of dendritic cells, and its impact on immune responses.

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Authors and Affiliations

  1. H. Lee Moffitt Cancer Center, Tampa, FL, USA

    Pingyan Cheng & Hao Liu

  2. The Wistar Institute, Philadelphia, PA, USA

    Dmitry Gabrilovich

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  1. Pingyan Cheng
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  2. Hao Liu
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  3. Dmitry Gabrilovich
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Correspondence to Dmitry Gabrilovich .

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Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Room 213, Library Building, Union, New Jersey, USA

    M.A. Hayat

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Cheng, P., Liu, H., Gabrilovich, D. (2014). Notch Signaling in Differentiation and Function of Dendritic Cells. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 12. Stem Cells and Cancer Stem Cells, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8032-2_7

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