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Stem Cells and Cancer Stem Cells, Volume 12 pp 219–230Cite as

Preoptic Regulatory Factor-2, a Rhogap Domain Protein that Modifies Cell Cycle Progression and Apoptosis in the CNS

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Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 12))

Abstract

RhoGAPS are proteins that control Rho GTPases, small enzymes that regulate diverse cellular functions. Preoptic regulatory factor-2 (Porf-2) is a RhoGAP domain-containing protein that is both pro-apoptotic and anti-proliferative. It is widely distributed among vertebrate taxa and expressed in multiple organs and cell types. Porf-2 expression is regulated at the level of transcription by age, gender, location, gonadal hormones, and pituitary and growth regulating factors. It may help coordinate sexually dimorphic development and be a target for prevention or treatment of diseases that exhibit apoptotic or proliferative imbalance.

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Acknowledgements

 The author thanks first all of the students and collaborators whose innovation and hard work contributed to the basis of this overview of Porf-2, with special mention of Dr. Richard C. Ogden, Dr. Shuang Ma, Dr. Shuang-Bao Hu, and Dr. Andrea C. Gore. Special thanks are given for financial support from the National Institutes of Health, March of Dimes and Pharmaceutical Research and Manufacturers of America. The author also thanks Dr. Y. Slyvka and Dr. R. Savage for critical reading of the manuscript. Finally, the author fondly acknowledges her research mentors: Dr. Gladys King, Dr. Harry J. Karavolas, Dr. Jo Anne Brasel and Dr. Ronald S. Swerdloff, for their intellectual and professional example and guidance.

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Authors and Affiliations

  1. Department of Biomedical Sciences, Ohio University, Athens, OH, USA

    Felicia V. Nowak

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  1. Felicia V. Nowak
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Correspondence to Felicia V. Nowak .

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Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Room 213, Library Building, Union, New Jersey, USA

    M.A. Hayat

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Nowak, F.V. (2014). Preoptic Regulatory Factor-2, a Rhogap Domain Protein that Modifies Cell Cycle Progression and Apoptosis in the CNS. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 12. Stem Cells and Cancer Stem Cells, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8032-2_19

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