New Neoadjuvant Chemotherapy for Resectable Liver Metastases of Colorectal Cancer

  • Antoine Brouquet
  • Stéphane Benoist
  • Bernard NordlingerEmail author


Surgical resection is the only method for treating colorectal liver metastases, because it can ensure long-term survival and cure in some patients. Only approximately 20 % of colorectal cancer patients with liver metastases can undergo liver resection at the time of diagnosis. Modern chemotherapy regimens are received by other patients, which could achieve high response rates but are insufficient for cure. Recurrences are observed in the majority of patients who undergo liver resection despite developed surgical technique and improved surgical skills. Many patients with resectable metastases undergo neoadjuvant chemotherapy before liver resection. Its benefit in terms of long-term disease control has been recently demonstrated, but neoadjuvant chemotherapy has also potential disadvantages, in particular chemotherapy-associated liver injury.


Liver Metastasis Preoperative Chemotherapy Colorectal Liver Metastasis Tumor Regression Grade Undergo Liver Resection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht and People's Medical Publishing House 2017

Authors and Affiliations

  • Antoine Brouquet
    • 1
    • 2
  • Stéphane Benoist
    • 1
    • 2
  • Bernard Nordlinger
    • 1
    • 2
    • 3
    Email author
  1. 1.Assistance Publique Hôpitaux de Paris, Université de VersaillesVersaillesFrance
  2. 2.Hôpital Ambroise ParéBoulogneFrance
  3. 3.Service de Chirurgie DigestiveHôpital Ambroise ParéBoulogne CedexFrance

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