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Clinical Epigenetics and Epigenomics

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Application of Clinical Bioinformatics

Part of the book series: Translational Bioinformatics ((TRBIO,volume 11))

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Abstract

Epigenetics is a molecular phenomenon that pertains to heritable changes in gene expression that do not involve changes in the DNA sequence. Epigenome, epigenetic modifications in a whole genome, play an essential role in the regulation of gene expression in both normal development and disease. DNA methylation, histone modification, and RNA-mediated targeting regulate many biological processes that are fundamental to the genesis of a spectrum of diseases. Here, we give a historical overview of the epigenomics field and focus on the recent progress that has been made in understanding the pathogenic role of cancerous disease, autoimmute disease, and metabolic disorder. We also discuss available traditional epigenetic therapies, epigenetic therapies currently in development, and the potential future use of epigenetic therapeutics in a clinical setting.

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Authors and Affiliations

  1. Department of Pulmonary Medicine, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China

    Nian Dong & Chengshui Chen

  2. Zhongshan Hospital, Shanghai Institute of Clinical Bioinformatics, Fudan University Center for Clinical Bioinformatics, Biomedical Research Center, Fudan University, Shanghai, China

    Lin Shi

  3. Zhabei District Hospital of Traditional Chinese Medicine, Yanchang Middle Road No. 288, Jingan District, Shanghai, China

    Wenhuan Ma

  4. Zhongshan Hospital, Fudan University, Shanghai Institute of Clinical Bioinformatics, Shanghai, China

    Xiangdong Wang

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  1. Nian Dong
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  2. Lin Shi
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  3. Chengshui Chen
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  4. Wenhuan Ma
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  5. Xiangdong Wang
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Correspondence to Chengshui Chen .

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Editors and Affiliations

  1. Shanghai Inst.of Clinical Bioinformatics, Zhongshan Hospital, Fudan University, Shang Hai, China

    Xiangdong Wang

  2. Institute of Health Care Engineering, Graz University of Technology, Graz, Austria

    Christian Baumgartner

  3. School Of Medicine & Medical Science, University College Dublin, Dublin 4, Ireland

    Denis C. Shields

  4. Health and Tropical Medicine, Tulane University School of Public Healt, New Orleans, Louisiana, USA

    Hong-Wen Deng

  5. Section of Clinical Bioinformatics, Swiss Institute of Bioinformatics, Switzerland

    Jacques S Beckmann

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Dong, N., Shi, L., Chen, C., Ma, W., Wang, X. (2016). Clinical Epigenetics and Epigenomics. In: Wang, X., Baumgartner, C., Shields, D., Deng, HW., Beckmann, J. (eds) Application of Clinical Bioinformatics. Translational Bioinformatics, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7543-4_5

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