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Neuropathic Pain: Sensory Nerve Injury or Motor Nerve Injury?

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Translational Research in Pain and Itch

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 904))

Abstract

Peripheral nerve injury often induces chronic neuropathic pain. Peripheral nerve is consisted of sensory fibers and motor fibers, it is questioned injury to which type of fibers is responsible for generation of neuropathic pain? Because neuropathic pain is sensory disorder, it is generally believed that the disease should be induced by injury to sensory fibers. In recent years, however, emergent evidence shows that motor fiber injury but not sensory fiber injury is necessary and sufficient for induction of neuropathic pain. Motor fiber injury leads to neuropathic pain by upregulating pro-inflammatory cytokines and brain-derived neurotrophic factor in pain pathway.

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Acknowledgment

This work was supported by grants from the National Natural Science Foundation of China (U1201223 and 8137119) and from Natural Science Foundation of Guangdong Province, China (Yq2013008).

Conflict of Interest Statement

The authors have declared that no conflict of interest exists.

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  1. Pain Research Center and Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, 74 Zhongshan Rd. 2, Guangzhou, 510080, People’s Republic of China

    Xian-Guo Liu, Rui-Ping Pang, Li-Jun Zhou, Xu-Hong Wei & Ying Zang

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  1. Dep of Anatomy,Histology and Embryology, Inst of Basic Med Sci Neroscien Cntr, Beijing, China

    Chao Ma

  2. Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China

    Yuguang Huang

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Liu, XG., Pang, RP., Zhou, LJ., Wei, XH., Zang, Y. (2016). Neuropathic Pain: Sensory Nerve Injury or Motor Nerve Injury?. In: Ma, C., Huang, Y. (eds) Translational Research in Pain and Itch. Advances in Experimental Medicine and Biology, vol 904. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7537-3_5

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