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Drug Use Trajectories Among Minority Youth pp 399–426Cite as

A Contextual-Genetics Approach to Adolescent Drug Use and Sexual Risk Behavior

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Abstract

In this chapter, we describe a research program that began in 2005 that was designed to refine etiologic models of drug use and sexual risk behavior, as well as the prevention programs the models inform. We were motivated to start this research because inclusive reviews of programs designed to prevent drug use/abuse and sexual risk behavior reveal mixed results. Many prevention programs do not attain their goals, and others are effective for some subgroups but not others (Foxcroft 2006; Foxcroft et al. 2003; Kraemer et al. 2002; White and Pitts 1998), suggesting that the causes of these risk behaviors are not yet well enough understood for prevention efforts to achieve large and reliable effects. This suggested to us a need for new approaches to etiologic models of drug use/abuse and sexual risk behavior, particularly greater articulation of the ways in which interactions among genetic, psychosocial, and developmental processes can inform them. Concurrent advances in both knowledge and technology related to basic genetics and epigenetic processes have created unprecedented opportunities for conceptual integration. We responded to this challenge and this opportunity by initiating a research program that uses findings from gene-environment interplay, developmental, and epigenetic research conducted with rural African Americans and participants in the Iowa Adoption Studies (IAS) to refine etiologic models in ways that increase their predictive utility.

This research was supported by Award Number 3R01AA012768-09S1 from the National Institute on Alcohol Abuse and Alcoholism and by Awards Numbers 5R01DA021736, 5R01DA019230, 3R01DA021736-04S1, 5R01DA010923-04S1, and 1P30DA027827 from the National Institute on Drug Abuse. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute on Alcohol Abuse and Alcoholism, the National Institute on Drug Abuse, or the National Institutes of Health.

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References

  • Beach, S. R. H., Brody, G. H., Gunter, T. D., Packer, H., Wernett, P., & Philibert, R. A. (2010a). Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder. Journal of Family Psychology, 24(1), 12–20.

    Article  Google Scholar 

  • Beach, S. R. H., Brody, G. H., Todorov, A., Gunter, T. D., & Philibert, R. A. (2010b). Methylation at SLC6A4 is linked to family history of child abuse: An examination of the Iowa Adoptee sample. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 153B(2), 710–713.

    Google Scholar 

  • Beitchman, J. H., Davidge, K. M., Kennedy, J. L., Atkinson, L., Lee, V., Shapiro, S., et al. (2003). The serotonin transporter gene in aggressive children with and without ADHD and nonaggressive matched controls. Annals of the New York Academy of Sciences, 1008, 248–251.

    Article  Google Scholar 

  • Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135(6), 885–908.

    Article  Google Scholar 

  • Belsky, J., Jonassaint, C. R., Pluess, M., Stanton, M., Brummett, B., & Williams, R. (2009). Vulnerability genes or plasticity genes? Molecular Psychiatry, 14(8), 746–754.

    Article  Google Scholar 

  • Bradley, S. P., Rastellini, C., da Costa, M. A., Kowalik, T. F., Bloomenthal, A. B., Brown, M., et al. (2005). Gene silencing in the endocrine pancreas mediated by short-interfering RNA. Pancreas, 31(4), 373–379.

    Article  Google Scholar 

  • Brody, G. H., & Flor, D. L. (1996). Coparenting, family interactions, and competence among African American youths. In J. P. McHale & P. A. Cowan (Eds.), Understanding how family-level dynamics affect children’s development: Studies of two-parent families (pp. 77–91). San Francisco: Jossey-Bass.

    Google Scholar 

  • Brody, G. H., & Flor, D. L. (1997). Maternal psychological functioning, family processes, and child adjustment in rural, single-parent African American families. Developmental Psychology, 33(6), 1000–1011.

    Article  Google Scholar 

  • Brody, G. H., & Forehand, R. (1993). Prospective associations among family form, family processes, and adolescents’ alcohol and drug use. Behaviour Research and Therapy, 31(6), 587–593.

    Article  Google Scholar 

  • Brody, G. H., & Stoneman, Z. (1992). Child competence and developmental goals among rural Black families: Investigating the links. In I. E. Sigel, A. V. McGillicuddy-DeLisi, & J. J. Goodnow (Eds.), Parental belief systems: The psychological consequences for children (2nd ed., pp. 415–431). Hillsdale: Erlbaum.

    Google Scholar 

  • Brody, G. H., Neubaum, E., Boyd, G. M., & Dufour, M. (1997). Health consequences of alcohol use in rural America. In E. B. Robertson, Z. Sloboda, G. M. Boyd, L. Beatty, & N. J. Kozel (Eds.), Rural substance abuse: State of knowledge and issues (pp. 137–174). Rockville: U.S. Department of Health and Human Services.

    Google Scholar 

  • Brody, G. H., Flor, D. L., & Neubaum, E. (1998a). Coparenting processes and child competence among rural African-American families. In M. Lewis & C. Feiring (Eds.), Families, risk, and competence (pp. 227–243). Mahwah: Erlbaum.

    Google Scholar 

  • Brody, G. H., Flor, D. L., Hollett-Wright, N., & McCoy, J. K. (1998b). Children’s development of alcohol use norms: Contributions of parent and sibling norms, children’s temperaments, and parent–child discussions. Journal of Family Psychology, 12(2), 209–219.

    Article  Google Scholar 

  • Brody, G. H., Flor, D. L., & Gibson, N. M. (1999). Linking maternal efficacy beliefs, developmental goals, parenting practices, and child competence in rural single-parent African American families. Child Development, 70(5), 1197–1208.

    Article  Google Scholar 

  • Brody, G. H., Ge, X., Katz, J., & Arias, I. (2000). A longitudinal analysis of internalization of parental alcohol-use norms and adolescent alcohol use. Applied Developmental Science, 4(2), 71–79.

    Article  Google Scholar 

  • Brody, G. H., Ge, X., Conger, R. D., Gibbons, F. X., Murry, V. M., Gerrard, M., et al. (2001). The influence of neighborhood disadvantage, collective socialization, and parenting on African American children’s affiliation with deviant peers. Child Development, 72(4), 1231–1246.

    Article  Google Scholar 

  • Brody, G. H., Murry, V. M., Kim, S., & Brown, A. C. (2002). Longitudinal pathways to competence and psychological adjustment among African American children living in rural single-parent households. Child Development, 73(5), 1505–1516.

    Article  Google Scholar 

  • Brody, G. H., Ge, X., Kim, S. Y., Murry, V. M., Simons, R. L., Gibbons, F. X., et al. (2003). Neighborhood disadvantage moderates associations of parenting and older sibling problem attitudes and behavior with conduct disorders in African American children. Journal of Consulting and Clinical Psychology, 71(2), 211–222.

    Article  Google Scholar 

  • Brody, G. H., Murry, V. M., Gerrard, M., Gibbons, F. X., Molgaard, V., McNair, L. D., et al. (2004). The Strong African American Families program: Translating research into prevention programming. Child Development, 75(3), 900–917.

    Article  Google Scholar 

  • Brody, G. H., Murry, V. M., McNair, L. D., Chen, Y.-f., Gibbons, F. X., Gerrard, M., et al. (2005a). Linking changes in parenting to parent–child relationship quality and youth self-control: The Strong African American Families program. Journal of Research on Adolescence, 15(1), 47–69.

    Article  Google Scholar 

  • Brody, G. H., Kim, S., Murry, V. M., & Brown, A. C. (2005b). Longitudinal links among parenting, self-presentations to peers, and the development of externalizing and internalizing symptoms in African American siblings. Development and Psychopathology, 17(1), 185–205.

    Article  Google Scholar 

  • Brody, G. H., Chen, Y.-f., Murry, V. M., Ge, X., Simons, R. L., Gibbons, F. X., et al. (2006a). Perceived discrimination and the adjustment of African American youths: A five-year longitudinal analysis with contextual moderation effects. Child Development, 77(5), 1170–1189.

    Article  Google Scholar 

  • Brody, G. H., Murry, V. M., Gerrard, M., Gibbons, F. X., McNair, L. D., Brown, A. C., et al. (2006b). The Strong African American Families program: Prevention of youths’ high-risk behavior and a test of a model of change. Journal of Family Psychology, 20(1), 1–11.

    Article  Google Scholar 

  • Brody, G. H., Murry, V. M., Kogan, S. M., Gerrard, M., Gibbons, F. X., Molgaard, V., et al. (2006c). The Strong African American Families program: A cluster-randomized prevention trial of long-term effects and a mediational model. Journal of Consulting and Clinical Psychology, 74(2), 356–366.

    Article  Google Scholar 

  • Brody, G. H., Beach, S. R. H., Philibert, R. A., Chen, Y.-f., & Murry, V. M. (2009a). Prevention effects moderate the association of 5-HTTLPR and youth risk behavior initiation: Gene × environment hypotheses tested via a randomized prevention design. Child Development, 80, 645–661.

    Article  Google Scholar 

  • Brody, G. H., Beach, S. R. H., Philibert, R. A., Chen, Y.-f., Lei, M.-K., Murry, V. M., et al. (2009b). Parenting moderates a genetic vulnerability factor in longitudinal increases in youths’ substance use. Journal of Consulting and Clinical Psychology, 77(1), 1–11.

    Article  Google Scholar 

  • Brody, G. H., Chen, Y.-f., & Kogan, S. M. (2010a). A cascade model connecting life stress to risk behavior among rural African American emerging adults. Development and Psychopathology, 22(3), 667–678.

    Article  Google Scholar 

  • Brody, G. H., Chen, Y.-f., Kogan, S. M., Murry, V. M., & Brown, A. C. (2010b). Long-term effects of the Strong African American Families program on youths’ alcohol use. Journal of Consulting and Clinical Psychology, 78(2), 281–285.

    Article  Google Scholar 

  • Bronfenbrenner, U., & Ceci, S. J. (1994). Nature-nurture reconceptualized in developmental perspective: A bioecological model. Psychological Review, 101(4), 568–586.

    Article  Google Scholar 

  • Caprara, G. V., Barbaranelli, C., Pastorelli, C., Bandura, A., & Zimbardo, P. G. (2000). Prosocial foundations of children’s academic achievement. Psychological Science, 11(4), 302–306.

    Article  Google Scholar 

  • Centers for Disease Control and Prevention. (1998). Risks for HIV infection among persons residing in rural areas and small cities: Selected sites, southern United States, 1995–1996. Morbidity and Mortality Weekly Report, 47, 974–978.

    Google Scholar 

  • Centers for Disease Control and Prevention. (2006). HIV/AIDS surveillance report (p. 2008). Washington, DC: U.S. Department of Health and Human Services.

    Google Scholar 

  • Cloninger, C. R., Svrakic, D. M., & Przybeck, T. R. (1993). A psychobiological model of temperament and character. Archives of General Psychiatry, 50(12), 975–990.

    Article  Google Scholar 

  • Conner, B. T., Hellemann, G. S., Ritchie, T. L., & Noble, E. P. (2010). Genetic, personality, and environmental predictors of drug use in adolescents. Journal of Substance Abuse Treatment, 38(2), 178–190.

    Article  Google Scholar 

  • Covault, J., Tennen, H., Armeli, S., Conner, T. S., Herman, A. I., Cillessen, A. H. N., et al. (2007). Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use. Biological Psychiatry, 61(5), 609–616.

    Article  Google Scholar 

  • Davidge, K. M., Atkinson, L., Douglas, L., Lee, V., Shapiro, S., Kennedy, J. L., et al. (2004). Association of the serotonin transporter and 5HT1Dbeta receptor genes with extreme, persistent and pervasive aggressive behaviour in children. Psychiatric Genetics, 14(3), 143–146. URL.

    Article  Google Scholar 

  • Deater-Deckard, K., Fulker, D. W., & Plomin, R. (1999). A genetic study of the family environment in the transition to early adolescence. Journal of Child Psychology and Psychiatry, 40(5), 769–775.

    Article  Google Scholar 

  • DiClemente, R. J., Wingood, G. M., Crosby, R., Sionean, C., Cobb, B. K., Harrington, K., et al. (2001). Parental monitoring: Association with adolescents’ risk behaviors. Pediatrics, 107(6), 1363–1368.

    Article  Google Scholar 

  • Ding, Y.-C., Chi, H.-C., Grady, D. L., Morishima, A., Kidd, J. R., Kidd, K. K., et al. (2002). Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proceedings of the National Academy of Sciences of the United States of America, 99(1), 309–314.

    Article  Google Scholar 

  • Disotell, T. R. (2000). Human genomic variation. Genome Biology, 1(5), comment2004.1–3.

    Google Scholar 

  • Eckhardt, F., Lewin, J., Cortese, R., Rakyan, V. K., Attwood, J., Burger, M., et al. (2006). DNA methylation profiling of human chromosomes 6, 20 and 22. Nature Genetics, 38(12), 1378–1385.

    Article  Google Scholar 

  • Ellickson, P. L., Tucker, J. S., & Klein, D. J. (2001). High-risk behaviors associated with early smoking: Results from a 5-year follow-up. Journal of Adolescent Health, 28(6), 465–473.

    Article  Google Scholar 

  • Espeland, M. A., Dotson, K., Jaramillo, S. A., Kahn, S. E., Harrison, B., Montez, M., et al. (2006). Consent for genetics studies among clinical trial participants: Findings from Action for Health in Diabetes (Look AHEAD). Clinical Trials, 3(5), 443–456.

    Article  Google Scholar 

  • Fabre, V., Boutrel, B., Hanoun, N., Lanfumey, L., Fattaccini, C. M., Demeneix, B., et al. (2000). Homeostatic regulation of serotonergic function by the serotonin transporter as revealed by nonviral gene transfer. Journal of Neuroscience, 20(13), 5065–5075.

    Google Scholar 

  • Feinberg, A. P. (2008). Epigenetics at the epicenter of modern medicine. Journal of the American Medical Association, 299(11), 1345–1350.

    Article  Google Scholar 

  • Flory, J. D., Newcorn, J. H., Miller, C., Harty, S., & Halperin, J. M. (2007). Serotonergic function in children with attention-deficit hyperactivity disorder: Relationship to later antisocial personality disorder. British Journal of Psychiatry, 190, 410–414.

    Article  Google Scholar 

  • Foxcroft, D. R. (2006). Alcohol misuse prevention for young people: A rapid review of recent evidence. Oxford: Oxford Brookes University.

    Google Scholar 

  • Foxcroft, D. R., Ireland, D., Lister-Sharp, D. J., Lowe, G., & Breen, R. (2003). Longer-term primary prevention for alcohol misuse in young people: A systematic review. Addiction, 98(4), 397–411.

    Article  Google Scholar 

  • Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., et al. (2005). Epigenetic differences arise during the lifetime of monozygotic twins. Proceedings of the National Academy of Sciences of the United States of America, 102(30), 10604–10609.

    Article  Google Scholar 

  • French, K., Finkbiner, R., & Duhamel, L. (2002). Patterns of substance use among minority youth and adults in the United States: An overview and synthesis of national survey findings. Fairfax: Department of Health and Human Services. URL.

    Google Scholar 

  • Galea, S., & Rudenstine, S. (2005). Challenges in understanding disparities in drug use and its consequences. Journal of Urban Health, 82(2), iii5–iii12. Suppl. 3.

    Google Scholar 

  • Gerra, G., Garofano, L., Castaldini, L., Rovetto, F., Zaimovic, A., Moi, G., et al. (2005). Serotonin transporter promoter polymorphism genotype is associated with temperament, personality traits and illegal drugs use among adolescents. Journal of Neural Transmission, 112(10), 1397–1410.

    Article  Google Scholar 

  • Gibbons, F. X., Gerrard, M., Cleveland, M. J., Wills, T. A., & Brody, G. H. (2004). Perceived discrimination and substance use in African American parents and their children: A panel study. Journal of Personality and Social Psychology, 86(4), 517–529.

    Article  Google Scholar 

  • Grafodatskaya, D., Choufani, S., Ferreira, J. C., Butcher, D. T., Lou, Y., Zhao, C., et al. (2010). EBV transformation and cell culturing destabilizes DNA methylation in human lymphoblastoid cell lines. Genomics, 95, 73–83.

    Article  Google Scholar 

  • Green, D., Cushman, M., Dermond, N., Johnson, E. A., Castro, C., Arnett, D., et al. (2006). Obtaining informed consent for genetic studies: The multiethnic study of atherosclerosis. American Journal of Epidemiology, 164(9), 845–851.

    Article  Google Scholar 

  • Guo, J., Chung, I.-J., Hill, K. G., Hawkins, J. D., Catalano, R. F., & Abbott, R. D. (2002). Developmental relationships between adolescent substance use and risky sexual behavior in young adulthood. Journal of Adolescent Health, 31(4), 354–362.

    Article  Google Scholar 

  • Haberstick, B. C., Smolen, A., & Hewitt, J. K. (2006). Family-based association test of the 5HTTLPR and aggressive behavior in a general population sample of children. Biological Psychiatry, 59(9), 836–843.

    Article  Google Scholar 

  • Hall, H. I., Li, J., & McKenna, M. T. (2005). HIV in predominantly rural areas of the United States. The Journal of Rural Health, 21(3), 245–254.

    Article  Google Scholar 

  • Halperin, J. M., Newcorn, J. H., Schwartz, S. T., Sharma, V., Siever, L. J., Koda, V. H., et al. (1997). Age-related changes in the association between serotonergic function and aggression in boys with ADHD. Biological Psychiatry, 41(6), 682–689.

    Article  Google Scholar 

  • Halperin, J. M., Kalmar, J. H., Schulz, K. P., Marks, D. J., Sharma, V., & Newcorn, J. H. (2006). Elevated childhood serotonergic function protects against adolescent aggression in disruptive boys. Journal of the American Academy of Child and Adolescent Psychiatry, 45, 833–840.

    Article  Google Scholar 

  • Hamer, D. (2002). Rethinking behavior genetics. Science, 298, 71–72.

    Article  Google Scholar 

  • Hawkins, J. D., Catalano, R. F., & Miller, J. Y. (1992). Risk and protective factors for alcohol and other drug problems in adolescence and early adulthood: Implications for substance abuse prevention. Psychological Bulletin, 112(1), 64–105.

    Article  Google Scholar 

  • Heath, A. C., Jardine, R., & Martin, N. G. (1989). Interactive effects of genotype and social environment on alcohol consumption in female twins. Journal of Studies on Alcohol, 50(1), 38–48. URL.

    Article  Google Scholar 

  • Heath, A. C., Eaves, L. J., & Martin, N. G. (1998). Interaction of marital status and genetic risk for symptoms of depression. Twin Research, 1(3), 119–122.

    Article  Google Scholar 

  • Herd, D. (1994). Predicting drinking problems among Black and White men: Results from a national survey. Journal of Studies on Alcohol, 55, 61–71.

    Article  Google Scholar 

  • Herman, A. I., Philbeck, J. W., Vassilopoulos, N. L., & Depetrillo, P. B. (2003). Serotonin transporter promoter polymorphism and differences in alcohol consumption behavior in a college student population. Alcohol and Alcoholism, 38(5), 446–449.

    Article  Google Scholar 

  • Hopfer, C. J., Timberlake, D., Haberstick, B. C., Lessem, J. M., Ehringer, M. A., Smolen, A., et al. (2005). Genetic influences on quantity of alcohol consumed by adolescents and young adults. Drug and Alcohol Dependence, 78, 187–193.

    Article  Google Scholar 

  • Howe, G. W., Beach, S. R. H., & Brody, G. H. (2010). Microtrial methods for translating gene-environment dynamics into preventive interventions. Prevention Science, 11(4), 343–354.

    Article  Google Scholar 

  • Jacobson, J. O., Robinson, P. L., & Bluthenthal, R. N. (2007). Racial disparities in completion rates from publicly funded alcohol treatment: Economic resources explain more than demographics and addiction severity. Health Services Research, 42(2), 773–794.

    Article  Google Scholar 

  • Johnson, P. O., & Fay, L. C. (1950). The Johnson-Neyman technique: Its theory and application. Psychometrika, 15, 349–367.

    Article  Google Scholar 

  • Johnson, P. O., & Neyman, J. (1936). Tests of certain linear hypotheses and their applications to some educational problems. Statistical Research Memoirs, 1, 57–93.

    Google Scholar 

  • Kahn, R. S., Khoury, J., Nichols, W. C., & Lanphear, B. P. (2003). Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors. Journal of Pediatrics, 143(1), 104–110.

    Article  Google Scholar 

  • Kaufman, J., Yang, B.-Z., Douglas-Palumberi, H., Crouse-Artus, M., Lipschitz, D., Krystal, J. H., et al. (2007). Genetic and environmental predictors of early alcohol use. Biological Psychiatry, 61, 1228–1234.

    Article  Google Scholar 

  • Kellam, S. G., & Van Horn, Y. V. (1997). Life course development, community epidemiology, and preventive trials: A scientific structure for prevention research. American Journal of Community Psychology, 25(2), 177–188.

    Article  Google Scholar 

  • Kendler, K. S., & Eaves, L. (1986). Models for the joint effect of genotype and environment on liability to psychiatric illness. American Journal of Psychiatry, 143(3), 279–289.

    Article  Google Scholar 

  • Kendler, K. S., Aggen, S. H., Prescott, C. A., Jacobson, K. C., & Neale, M. C. (2004). Level of family dysfunction and genetic influences on smoking in women. Psychological Medicine, 34(7), 1263–1269.

    Article  Google Scholar 

  • Kline, A. (1996). Pathways into drug user treatment: The influence of gender and racial/ethnic identity. Substance Use and Misuse, 31(3), 323–342.

    Article  Google Scholar 

  • Kogan, S. M., Berkel, C., Chen, Y.-F., Brody, G. H., & Murry, V. M. (2006). Metro status and African-American adolescents’ risk for substance use. Journal of Adolescent Health, 38(4), 454–457.

    Article  Google Scholar 

  • Kraemer, H. C., Wilson, G. T., Fairburn, C. G., & Agras, W. S. (2002). Mediators and moderators of treatment effects in randomized clinical trials. Archives of General Psychiatry, 59(10), 877–883.

    Article  Google Scholar 

  • Laucht, M., Becker, K., El-Faddagh, M., Hohm, E., & Schmidt, M. H. (2005). Association of the DRD4 exon III polymorphism with smoking in fifteen-year-olds: A mediating role for novelty seeking? Journal of the American Academy of Child and Adolescent Psychiatry, 44(5), 477–484.

    Article  Google Scholar 

  • Laucht, M., Becker, K., Blomeyer, D., & Schmidt, M. H. (2007). Novelty seeking involved in mediating the association between the dopamine D4 receptor gene exon III polymorphism and heavy drinking in male adolescents: Results from a high-risk community sample. Biological Psychiatry, 61(1), 87–92.

    Article  Google Scholar 

  • Laucht, M., Becker, K., Frank, J., Schmidt, M. H., Esser, G., Treutlein, J., et al. (2008). Genetic variation in dopamine pathways differentially associated with smoking progression in adolescence. Journal of the American Academy of Child and Adolescent Psychiatry, 47(6), 673–681.

    Article  Google Scholar 

  • Leigh, B. C., & Stahl, R. (1993). Substance use and risky sexual behavior for exposure to HIV: Issues in methodology, interpretation, and prevention. American Psychologist, 48(10), 1035–1045.

    Article  Google Scholar 

  • Lerner, R. M. (1991). Changing organism-context relations as the basic process of development: A developmental context and perspective. Developmental Psychology, 27(1), 27–32.

    Article  Google Scholar 

  • Levine, S. B., & Coupey, S. M. (2003). Adolescent substance use, sexual behavior, and metropolitan status: Is “urban” a risk factor? Journal of Adolescent Health, 32, 350–355.

    Article  Google Scholar 

  • Levitan, R. D., Masellis, M., Lam, R. W., Kaplan, A. S., Davis, C., Tharmalingam, S., et al. (2006). A birth-season/DRD4 gene interaction predicts weight gain and obesity in women with seasonal affective disorder: A seasonal thrifty phenotype hypothesis. Neuropsychopharmacology, 31(11), 2498–2503.

    Article  Google Scholar 

  • Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., et al. (1997). Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science, 277(5332), 1659–1662.

    Article  Google Scholar 

  • Lowman, C., & Le Fauve, C. E. (2003). Health disparities and the relationship between race, ethnicity, and substance abuse treatment outcomes. Alcoholism, Clinical and Experimental Research, 27(8), 1324–1326.

    Article  Google Scholar 

  • Luciano, M., Zhu, G., Kirk, K. M., Whitfield, J. B., Butler, R., Heath, A. C., et al. (2004). Effects of dopamine receptor D4 variation on alcohol and tobacco use and on novelty seeking: Multivariate linkage and association analysis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 124B(1), 113–123.

    Article  Google Scholar 

  • McClelland, G. H., & Judd, C. M. (1993). Statistical difficulties of detecting interactions and moderator effects. Psychological Bulletin, 114(2), 376–390.

    Article  Google Scholar 

  • McGowan, P. O., Sasaki, A., Huang, T. C. T., Unterberger, A., Suderman, M., Ernst, C., et al. (2008). Promoter-wide hypermethylation of ribosomal RNA gene promoter in the suicide brain [electronic article]. PLoS ONE, 3(5). e2085.

    Google Scholar 

  • McGowan, P. O., Sasaki, A., D’Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., et al. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience, 12(3), 342–348.

    Article  Google Scholar 

  • McQuillan, G. M., Porter, K. S., Agelli, M., & Kington, R. (2003). Consent for genetic research in a general population: The NHANES experience. Genetics in Medicine, 5(1), 35–42.

    Article  Google Scholar 

  • McQuillan, G. M., Pan, Q., & Porter, K. S. (2006). Consent for genetic research in a general population: An update on the National Health and Nutrition Examination Survey experience. Genetics in Medicine, 8(6), 354–360.

    Article  Google Scholar 

  • Mitsis, E. M., Halperin, J. M., & Newcorn, J. H. (2000). Serotonin and aggression in children. Current Psychiatry Reports, 2(2), 95–101.

    Article  Google Scholar 

  • Munafò, M. R., Lingford-Hughes, A. R., Johnstone, E. C., & Walton, R. T. (2005). Association between the serotonin transporter gene and alcohol consumption in social drinkers. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 135B(1), 10–14.

    Article  Google Scholar 

  • Murry, V. M., & Brody, G. H. (2004). Partnering with community stakeholders: Engaging rural African American families in basic research and the Strong African American Families preventive intervention program. Journal of Marital and Family Therapy, 30(3), 271–283.

    Article  Google Scholar 

  • Murry, V. M., Brown, P. A., Brody, G. H., Cutrona, C. E., & Simons, R. L. (2001). Racial discrimination as a moderator of the links among stress, maternal psychological functioning, and family relationships. Journal of Marriage and Family, 63(4), 915–926.

    Article  Google Scholar 

  • Pandina, R. J., & Johnson, V. L. (1999). Why people use, abuse, and become dependent on drugs: Toward a heuristic model. In M. D. Glantz & C. R. Hartel (Eds.), Drug abuse: Origins and interventions (pp. 119–147). Washington, DC: American Psychological Association.

    Chapter  Google Scholar 

  • Petraitis, J., Flay, B. R., & Miller, T. Q. (1995). Reviewing theories of adolescent substance use: Organizing pieces in the puzzle. Psychological Bulletin, 117(1), 67–86.

    Article  Google Scholar 

  • Philibert, R. A., Zadorozhnyaya, O., Beach, S. R. H., & Brody, G. H. (2008a). Comparison of the genotyping results using DNA obtained from blood and saliva. Psychiatric Genetics, 18(6), 275–281.

    Article  Google Scholar 

  • Philibert, R. A., Sandhu, H., Hollenbeck, N., Gunter, T., Adams, W., & Madan, A. (2008b). The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B(5), 543–549.

    Article  Google Scholar 

  • Proctor, B. D., & Dalaker, J. (2003)Poverty in the United States: 2002 (Current population reports, P60-222). Washington, DC: U.S. Bureau of the Census.

    Google Scholar 

  • Ray, L. A., Bryan, A., MacKillop, J., McGeary, J., Hesterberg, K., & Hutchison, K. E. (2008). The dopamine D4 Receptor (DRD4) gene exon III polymorphism, problematic alcohol use and novelty seeking: Direct and mediated genetic effects. Addiction Biology, 14(2), 238–244.

    Article  Google Scholar 

  • Reardon, S. F., & Buka, S. L. (2002). Differences in onset and persistence of substance abuse and dependence among Whites, Blacks, and Hispanics. Public Health Reports, 117(Suppl 1), S51–S59.

    Google Scholar 

  • Rodríguez, S., Huang, S., Chen, X.-h., Gaunt, T. R., Syddall, H. E., Gilg, J. A., et al. (2006). A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys. Pharmacogenetics and Genomics, 16(1), 15–23.

    Article  Google Scholar 

  • Rose, R. J., Dick, D. M., Viken, R. J., & Kaprio, J. (2001). Gene–environment interaction in patterns of adolescent drinking: Regional residency moderates longitudinal influences on alcohol use. Alcoholism, Clinical and Experimental Research, 25(5), 637–643.

    Article  Google Scholar 

  • Rutter, M. L. (1985). Resilience in the face of adversity: Protective factors and resistance to psychiatric disturbance. British Journal of Psychiatry, 147, 598–611.

    Article  Google Scholar 

  • Rutter, M. L. (2005). Environmentally mediated risks for psychopathology: Research strategies and findings. Journal of the American Academy of Child and Adolescent Psychiatry, 44(1), 3–18.

    Article  Google Scholar 

  • Rutter, M. L. (2007). Proceeding form observed correlation to causal inference: The use of natural experiments. Perspectives on Psychological Science, 2(4), 377–395.

    Article  Google Scholar 

  • Rutter, M. L., & Silberg, J. (2002). Gene-environment interplay in relation to emotional and behavioral disturbance. Annual Review of Psychology, 53(1), 463–490.

    Article  Google Scholar 

  • Sakai, J. T., Young, S. E., Stallings, M. C., Timberlake, D., Smolen, A., Stetler, G. L., et al. (2006). Case–control and within-family tests for an association between conduct disorder and 5HTTLPR. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 141B(8), 825–832.

    Article  Google Scholar 

  • Sakai, J. T., Lessem, J. M., Haberstick, B. C., Hopfer, C. J., Smolen, A., Ehringer, M. A., et al. (2007). Case–control and within-family tests for association between 5HTTLPR and conduct problems in a longitudinal adolescent sample. Psychiatric Genetics, 17(4), 207–214.

    Article  Google Scholar 

  • Schmidt, L., Greenfield, T., & Mulia, N. (2006). Unequal treatment: Racial and ethnic disparities in alcoholism treatment services. Alcohol Research & Health, 29(1), 49–54.

    Google Scholar 

  • Shields, P. G., Lerman, C., Audrain, J., Bowman, E. D., Main, D., Boyd, N. R., et al. (1998). Dopamine D4 receptors and the risk of cigarette smoking in African-Americans and Caucasians. Cancer Epidemiology, Biomarkers and Prevention, 7(6), 453–458.

    Google Scholar 

  • Simons, R. L., Chen, Y.-f., Stewart, E. A., & Brody, G. H. (2003). Incidents of discrimination and risk for delinquency: A longitudinal test of strain theory with an African American sample. Justice Quarterly, 20(4), 827–854.

    Article  Google Scholar 

  • Skowronek, M. H., Laucht, M., Hohm, E., Becker, K., & Schmidt, M. H. (2006). Interaction between the dopamine D4 receptor and the serotonin transporter promoter polymorphisms in alcohol and tobacco use among 15-year-olds. Neurogenetics, 7(4), 239–246.

    Article  Google Scholar 

  • Stack, K., Cortina, J., Samples, C., Zapata, M., & Arcand, L. F. (2000). Race, age, and back pain as factors in completion of residential substance abuse treatment by veterans. Psychiatric Services, 51(9), 1157–1161.

    Article  Google Scholar 

  • Stueve, A., & O’Donnell, L. N. (2005). Early alcohol initiation and subsequent sexual and alcohol risk behaviors among urban youths. American Journal of Public Health, 95(5), 887–893.

    Article  Google Scholar 

  • Tickamyer, A. R., & Duncan, C. M. (1990). Poverty and opportunity structure in rural America. Annual Review of Sociology, 16, 67–86.

    Article  Google Scholar 

  • Tubman, J. G., Windle, M., & Windle, R. C. (1996). Cumulative sexual intercourse patterns among middle adolescents: Problem behavior precursors and concurrent health risk behaviors. Journal of Adolescent Health, 18(3), 182–191.

    Article  Google Scholar 

  • Tucker, J. S., Orlando, M., & Ellickson, P. L. (2003). Patterns and correlates of binge drinking trajectories from early adolescence to young adulthood. Health Psychology, 22(1), 79–87.

    Article  Google Scholar 

  • Turkheimer, E., Haley, A., Waldron, M., D’Onofrio, B., & Gottesman, I. I. (2003). Socioeconomic status modifies heritability of IQ in young children. Psychological Science, 14(6), 623–628.

    Article  Google Scholar 

  • Vaughn, M. G., Beaver, K. M., DeLisi, M., Howard, M. O., & Perron, B. E. (2009). Dopamine D4 receptor gene exon III polymorphism associated with binge drinking attitudinal phenotype. Alcohol, 43(3), 179–184.

    Article  Google Scholar 

  • Wallace, J. M., Jr., Bachman, J. G., O’Malley, P. M., Johnston, L. D., Schulenberg, J. E., & Cooper, S. M. (2002). Tobacco, alcohol, and illicit drug use: Racial and ethnic differences among U.S. high school seniors, 1976–2000. Public Health Reports, 117(Suppl 1), S67–S75.

    Google Scholar 

  • Weinberg, N. Z., Rahdert, E., Colliver, J. D., & Glantz, M. D. (1998). Adolescent substance abuse: A review of the past 10 years. Journal of the American Academy of Child and Adolescent Psychiatry, 37, 252–261.

    Article  Google Scholar 

  • Whale, R., Quested, D. J., Laver, D., Harrison, P. J., & Cowen, P. J. (2000). Serotonin transporter (5-HTT) promoter genotype may influence the prolactin response to clomipramine. Psychopharmacology, 150(1), 120–122.

    Article  Google Scholar 

  • White, D., & Pitts, M. (1998). Educating young people about drugs: A systematic review. Addiction, 93(10), 1475–1487.

    Article  Google Scholar 

  • Wills, T. A., Gibbons, F. X., Gerrard, M., Murry, V. M., & Brody, G. H. (2003). Family communication and religiosity related to substance use and sexual behavior in early adolescence: A test for pathways through self-control and prototype perceptions. Psychology of Addictive Behaviors, 17(4), 312–323.

    Article  Google Scholar 

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Authors and Affiliations

  1. Center for Family Research, Institute for Behavioral Research, University of Georgia, Athens, GA, 30602, USA

    Gene H. Brody & Steven R. H. Beach

  2. Department of Behavioral Science and Health Education, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA

    Gene H. Brody

  3. Department of Psychiatry, University of Iowa, Iowa City, IA, 52242, USA

    Robert A. Philibert

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  1. Gene H. Brody
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  3. Robert A. Philibert
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Correspondence to Gene H. Brody .

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  1. The New York Academy of Medicine and the American Association of Geographers, Glenn Dale, Maryland, USA

    Yonette F. Thomas

  2. Health Inequities and Global Health Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA

    LeShawndra N. Price

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Brody, G.H., Beach, S.R.H., Philibert, R.A. (2016). A Contextual-Genetics Approach to Adolescent Drug Use and Sexual Risk Behavior. In: Thomas, Y., Price, L. (eds) Drug Use Trajectories Among Minority Youth. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7491-8_19

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