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Non-coding RNA in Ovarian Development and Disease

  • J. Browning Fitzgerald
  • Jitu George
  • Lane K. ChristensonEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 886)

Abstract

The ovary’s primary function is to produce the mature female gamete, the oocyte that, following fertilization, can develop into an embryo, implant within the uterus and ultimately allow the mother’s genetic material to be passed along to subsequent generations. In addition to supporting the generation of the oocyte, the ovary and specific ephemeral tissues within it, follicles and corpora lutea, produce steroids that regulate all aspects of the reproductive system, including the hypothalamic/pituitary axis, the reproductive tract (uterus, oviduct, cervix), secondary sex characteristics all of which are also essential for pregnancy and subsequent nurturing of the offspring. To accomplish these critical roles, ovarian development and function are tightly regulated by a number of exogenous (hypothalamic/pituitary) and endogenous (intraovarian) hormones. Within ovarian cells, intricate signalling cascades and transcriptional and post-transcriptional gene regulatory networks respond to these hormonal influences to provide the exquisite control over all of the temporal and spatial events that must be synchronized to allow this organ to successfully complete its function. This book chapter will focus specifically on the role of non-coding RNAs, their identification and described functional roles within the ovary with respect to normal function and their possible involvement in diseases, which involve the ovary.

Keywords

Folliculogenesis MicroRNA Premature ovarian failure Ovarian cancer Endo-siRNA Long non-coding RNA 

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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • J. Browning Fitzgerald
    • 1
  • Jitu George
    • 1
  • Lane K. Christenson
    • 1
    Email author
  1. 1.Department of Molecular and Integrative PhysiologyUniversity of Kansas Medical CenterKansas CityUSA

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