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Surgical Treatment of Hepatocellular Carcinoma Accompanied with Portal Vein Tumor Thrombus

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Operative Techniques in Liver Resection

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Abstract

In the 1980s, Lee and Lin et al. [1, 2] performed a hepatectomy to treat hepatocellular carcinoma associated with portal vein tumor thrombus (PVTT). At first, this surgery was used only for PVTTs of the first branch of the portal vein and not for PVTTs invading the bifurcation or the trunk of the portal vein.

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References

  1. Lee NW, Wong J, Ong GB. The surgical management of primary carcinoma of the liver. World J Surg. 1982;6(1):66–75.

    Article  PubMed  CAS  Google Scholar 

  2. Lin TY, Lee CS, Chen KM, Chen CC. Role of surgery in the treatment of primary carcinoma of the liver: a 31-year experience. Br J Surg. 1987;74(9):839–42.

    Article  PubMed  CAS  Google Scholar 

  3. Kumada K, Ozawa K, Okamoto R, et al. Hepatic resection for advanced hepatocellular carcinoma with removal of portal vein tumor thrombi. Surgery. 1990;108(5):821–7.

    PubMed  CAS  Google Scholar 

  4. Yamaoka Y, Kumada K, Ino K, et al. Liver resection for hepatocellular carcinoma (HCC) with direct removal of tumor thrombi in the main portal vein. World J Surg. 1992;16(6):1172–6.

    Article  PubMed  CAS  Google Scholar 

  5. Chok KH, Cheung TT, Chan SC, et al. Surgical outcomes in hepatocellular carcinoma patients with portal vein tumor thrombosis. World J Surg. 2014;38:490–6.

    Article  PubMed  Google Scholar 

  6. Shi J, Lai EC, Li N, et al. Surgical treatment of hepatocellular carcinoma with portal vein tumor thrombus. Ann Surg Oncol. 2010;17(8):2073–80.

    Article  PubMed  Google Scholar 

  7. Zimmerman MA, Ghobrial RM, Tong MJ, et al. Recurrence of hepatocellular carcinoma following liver transplantation: a review of preoperative and postoperative prognostic indicators. Arch Surg. 2008;143(2):182–8.

    Article  PubMed  Google Scholar 

  8. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 1996;334(11):693–9.

    Article  PubMed  CAS  Google Scholar 

  9. Marsh JW, Dvorchik I, Bonham CA, et al. Is the pathologic TNM staging system for patients with hepatoma predictive of outcome? Cancer. 2000;88(3):538–43.

    Article  PubMed  CAS  Google Scholar 

  10. Yao FY, Ferrell L, Bass NM, et al. Liver transplantation for hepatocellular carcinoma: comparison of the proposed UCSF criteria with the Milan criteria and the Pittsburgh modified TNM criteria. Liver Transpl. 2002;8(9):765–74.

    Article  PubMed  Google Scholar 

  11. Zheng SS, Xu X, Wu J, et al. Liver transplantation for hepatocellular carcinoma: Hangzhou experiences. Transplantation. 2008;85(12):1726–32.

    Article  PubMed  CAS  Google Scholar 

  12. Fan J, Yang GS, Fu ZR, et al. Liver transplantation outcomes in 1,078 hepatocellular carcinoma patients: a multi-center experience in Shanghai, China. J Cancer Res Clin Oncol. 2009;135(10):1403–12.

    Article  PubMed  Google Scholar 

  13. Liver Cancer Study Group of Japan. The general rules for the clinical and pathological study of primary liver cancer, second english edition. Tokyo: Kanehara & Co., Ltd.; 2003.

    Google Scholar 

  14. Shuqun C, Mengchao W, Han C, et al. Tumor thrombus types influence the prognosis of hepatocellular carcinoma with the tumor thrombi in the portal vein. Hepatogastroenterology. 2007;54(74):499–502.

    PubMed  Google Scholar 

  15. Chen JS, Wang Q, Chen XL, et al. Clinicopathologic characteristics and surgical outcomes of hepatocellular carcinoma with portal vein tumor thrombosis. J Surg Res. 2012;175(2):243–50.

    Article  PubMed  Google Scholar 

  16. Toyosaka A, Okamoto E, Mitsunobu M, et al. Pathologic and radiographic studies of intrahepatic metastasis in hepatocellular carcinoma; the role of efferent vessels. HPB Surg. 1996;10(2):97–103.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  17. Okuda K, Ohtsuki T, Obata H, et al. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Cancer. 1985;56(4):918–28.

    Article  PubMed  CAS  Google Scholar 

  18. The Cancer of the Liver Italian Program (CLIP) Investigators. A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients. Hepatology. 1998;28(3):751–5.

    Article  Google Scholar 

  19. Wong VW, Chan SL, Mo F, et al. Clinical scoring system to predict hepatocellular carcinoma in chronic hepatitis B carriers. J Clin Oncol. 2010;28(10):1660–5.

    Article  PubMed  CAS  Google Scholar 

  20. Forner A, Reig ME, de Lope CR, Bruix J. Current strategy for staging and treatment: the BCLC update and future prospects. Semin Liver Dis. 2010;30(1):61–74.

    Article  PubMed  CAS  Google Scholar 

  21. Yau T, Tang VY, Yao TJ, et al. Development of Hong Kong Liver Cancer staging system with treatment stratification for patients with hepatocellular carcinoma. Gastroenterology. 2014;146(7):1691–700.

    Article  PubMed  Google Scholar 

  22. Minagawa M, Ikai I, Matsuyama Y, et al. Staging of hepatocellular carcinoma: assessment of the Japanese TNM and AJCC/UICC TNM systems in a cohort of 13,772 patients in Japan. Ann Surg. 2007;245(6):909–22.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Edge SB, editor. Liver. In: AJCC cancer staging manual. 7th ed. New York: Springer; 2009. p. 201–10.

    Google Scholar 

  24. Ikai I, Itai Y, Okita K, et al. Report of the 15th follow-up survey of primary liver cancer. Hepatol Res. 2004;28(1):21–9.

    Article  PubMed  Google Scholar 

  25. Shi J, Lai EC, Li N, et al. A new classification for hepatocellular carcinoma with portal vein tumor thrombus. J Hepatobiliary Pancreat Sci. 2011;18(1):74–80.

    Article  PubMed  Google Scholar 

  26. Jia WD. Key techniques in precise hepatectomy for hepatocellular carcinoma. Chin J General Surg. 2014;23(1):1–5.

    Google Scholar 

  27. Jia WD, Xu GL, Li JS, et al. Value of indocyanine green excretion test in predicting hepatic failure after hepatectomy. Chin J Dig Surg. 2011;10(1):61–3.

    Google Scholar 

  28. Makuuchi M, Kokudo N. Clinical practice guidelines for hepatocellular carcinoma: the first evidence based guidelines from Japan. World J Gastroenterol. 2006;12(5):828–9.

    PubMed  PubMed Central  Google Scholar 

  29. Schneider PD. Preoperative assessment of liver function. Surg Clin North Am. 2004;84(2):355–73.

    Article  PubMed  Google Scholar 

  30. Clavien PA, Petrowsky H, DeOliveira ML, et al. Strategies for safer liver surgery and partial liver transplantation. N Engl J Med. 2007;356(15):1545–59.

    Article  PubMed  Google Scholar 

  31. Dong JH, Zheng SS, Chen XP, et al. Consensus on evaluation of hepatic functional reserve before hepatectomy (2011 edition). Chin J Dig Surg. 2011;10(1):22–5.

    Google Scholar 

  32. Kudo M, Izumi N, Kokudo N, et al. Management of hepatocellular carcinoma in Japan: consensus-based clinical practice guidelines proposed by the Japan Society of Hepatology (JSH) 2010 updated version. Dig Dis. 2011;29(3):339–64.

    Article  PubMed  Google Scholar 

  33. Benson AB, D’Angelica MI, Abrams TA, et al. Hepatobiliary cancers, version 2.2014. J Natl ComprCancNetw. 2014; 12(8):1152–82.

    Google Scholar 

  34. Zeng ZP, Xu ZQ, Zhou CC, et al. S. Efficacy of autogenous peritoneo-fascial patch graft in repairing portal vein. Chin J Dig Surg. 2013;12(2):145–6.

    Google Scholar 

  35. Chen XP, Qiu FZ, Wu ZD, et al. Effects of location and extension of portal vein tumor thrombus on long-term outcomes of surgical treatment for hepatocellular carcinoma. Ann Surg Oncol. 2006;13(7):940–6.

    Article  PubMed  Google Scholar 

  36. Ikai I, Hatano E, Hasegawa S, et al. Prognostic index for patients with hepatocellular carcinoma combined with tumor thrombosis in the major portal vein. J Am Coll Surg. 2006;202(3):431–8.

    Article  PubMed  Google Scholar 

  37. Matono R, Yoshiya S, Motomura T, et al. Factors linked to longterm survival of patients with hepatocellular carcinoma accompanied by tumour thrombus in the major portal vein after surgical resection. HPB (Oxford). 2012;14(4):247–53.

    Article  Google Scholar 

  38. Ban D, Shimada K, Yamamoto Y, et al. Efficacy of a hepatectomy and a tumor thrombectomy for hepatocellular carcinoma with tumor thrombus extending to the main portal vein. J Gastrointest Surg. 2009;13(11):1921–8.

    Article  PubMed  Google Scholar 

  39. Katagiri S, Yamamoto M. Multidisciplinary treatments for hepatocellular carcinoma with major portal vein tumor thrombus. Surg Today. 2014;44(2):219–26.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. General Surgery Department, Anhui Provincial Hospital, Hefei, Anhui, China

    Weidong Jia MD, PhD

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  1. Weidong Jia MD, PhD
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Correspondence to Weidong Jia MD, PhD .

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Editors and Affiliations

  1. Department of Surgery, West China Hospital, Chengdu, China

    Lunan Yan

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Jia, W. (2016). Surgical Treatment of Hepatocellular Carcinoma Accompanied with Portal Vein Tumor Thrombus. In: Yan, L. (eds) Operative Techniques in Liver Resection. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7411-6_16

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  • DOI: https://doi.org/10.1007/978-94-017-7411-6_16

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-017-7409-3

  • Online ISBN: 978-94-017-7411-6

  • eBook Packages: MedicineMedicine (R0)

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