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Intercellular Communication in Cancer pp 151–168Cite as

Cadherin-Based Cell-Cell Adhesions: Adhesion Structure, Signalling and Computational Modeling

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Abstract

Cadherins represent a large group (more than 100) of transmembrane cell surface glycoproteins that play central roles in tissue organization and morphogenesis by modulating cell-cell adhesions in a Ca++ dependent manner. In this chapter, we review the various types of cadherins, interacting partners of cadherins, the structure and assembly of cadherin-mediated cell-cell adhesions, force-sensitive nature of cadherin bonds, and the role of cadherins in cancer. Finally, we discuss about some of the different computational and mathematical approaches used to explore different aspects of cell-cell adhesions, and their relationship to cellular processes relevant to cancer.

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Authors and Affiliations

  1. Department of Biosciences and Bioengineering, IIT Bombay, Mumbai, India

    Sandeep Kumar & Shamik Sen

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  1. Sandeep Kumar
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  2. Shamik Sen
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Correspondence to Shamik Sen .

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  1. Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan, USA

    Mustapha Kandouz

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Kumar, S., Sen, S. (2015). Cadherin-Based Cell-Cell Adhesions: Adhesion Structure, Signalling and Computational Modeling. In: Kandouz, M. (eds) Intercellular Communication in Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7380-5_5

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