Abstract
Within a solid tumor, cancer cells interact with normal host cells as well as with insoluble and soluble factors, including extracellular matrix proteins and chemokines. Here, we survey the molecular mechanisms by which cancer cells interact with their surrounding microenvironment, with a particular focus on intercellular communication. This host-tumor crosstalk provides key signals that direct the growth, migration, and dissemination of cancer cells. Approaches that disrupt or coopt intercellular communication between the tumor and its host are exciting and potentially powerful anti-cancer therapeutic strategies.
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Abbreviations
- CAF:
-
Cancer-associated fibroblast
- CAR:
-
Coxsackie-adenovirus receptor
- CC:
-
Chemokine
- CCR:
-
Chemokine receptor
- CSC:
-
Cancerstem cell
- ECM:
-
Extracellular matrix
- EGF:
-
Epidermal growth factor
- EMT:
-
Epithelial-mesenchymal transition
- GJ:
-
Gap junction
- GJIC:
-
Gap junction intercellular communication
- HCC:
-
Hepatocellular carcinoma
- HGF:
-
Hepatocyte growth factor
- ICAM:
-
Intercellular adhesion molecule
- IL:
-
Interleukin
- LN:
-
Lymph node
- MSC:
-
Mesenchymal stem cell
- MVB:
-
Multi-vesicular body
- PDGF:
-
Platelet-derived growth factor
- SLN:
-
Sentinel lymph node
- TAK:
-
Transforming growth factor kinase
- siRNA:
-
Short interfering RNA
- TGF:
-
Transforming growth factor
- TNF:
-
Tumor necrosis factor
- VCAM:
-
Vascular cell adhesion molecule
- VEGF:
-
Vascular endothelial growth factor
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Pang, MF., Nelson, C.M. (2015). Intercellular Communication, the Tumor Microenvironment, and Tumor Progression. In: Kandouz, M. (eds) Intercellular Communication in Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7380-5_13
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DOI: https://doi.org/10.1007/978-94-017-7380-5_13
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