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Signaling Pathways Regulating Stem Cells

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Stem Cells: Basics and Clinical Translation

Part of the book series: Translational Medicine Research ((TRAMERE,volume 1))

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Abstract

Stem cells have a unique ability to self-renewal and a potential to differentiate into one or more types of specialized cells. These properties in vivo are commonly maintained and regulated by signaling pathways involved in cell-to-cell communications. Signaling communications occur between stem cells and the niche supporting cells, as well as between stem cells and their differentiated daughter cells. Different types of stem cells within the same tissue are also coordinately regulated by signaling pathways to maintain tissue architecture and function. Signaling pathways are also critical in mediating stem cell activation in response to tissue damage for accelerated regeneration. This chapter will review signaling mechanisms in controlling various behaviors of several well-characterized tissue stem cells, including self-renewal, differentiation, and regenerative activation of stem cells.

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  1. National Institute of Biological Sciences, Beijing, 102206, China

    Xingting Guo, Jun Chen, Zhaohui Li & Rongwen Xi

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    Robert Chunhua Zhao

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Guo, X., Chen, J., Li, Z., Xi, R. (2015). Signaling Pathways Regulating Stem Cells. In: Zhao, R. (eds) Stem Cells: Basics and Clinical Translation. Translational Medicine Research, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7273-0_6

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