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Stem Cells: Basics and Clinical Translation pp 85–109Cite as

Induced Pluripotent Stem Cell, a Rising Star in Regenerative Medicine

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Part of the book series: Translational Medicine Research ((TRAMERE,volume 1))

Abstract

The generation of induced pluripotent stem cells (iPSCs) is a milestone in biomedical researches. With the iPS technology, mouse somatic cells could be reprogrammed into a pluripotent state similar to that of embryonic stem cells (ESCs) by overexpression of only several defined transcription factors. This technology also enables the successful generation of human iPSCs from various human somatic cells and therefore avoids the ethical conflicts of ESCs that are derived from human embryos. The iPSCs generated from somatic cells of patients are generally considered to be free of immune rejection in autogenous transplantation therapy, thus they hold great therapeutic potential for producing personalized regenerative medicine. Besides, the autologous iPSCs from patients and the subsequent differentiation can be directly used for the disease modeling and drug screening in dishes. Though holding invaluable therapeutic potential, the iPS technology also faces some challenges such as immunogenicity, oncogenicity, in vitro differentiation propensities, and genome or epigenome integrities, which must be carefully evaluated before clinical translation. In this chapter, we briefly summarize the history and progress of the iPSC researches and the application of iPSCs in regenerative medicine and disease modeling.

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Authors and Affiliations

  1. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, People’s Republic of China

    Yihuan Mao, Yukai Wang, Libin Wang & Qi Zhou

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  1. Yihuan Mao
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  2. Yukai Wang
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  3. Libin Wang
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  4. Qi Zhou
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Correspondence to Qi Zhou .

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Editors and Affiliations

  1. Center of Excellence in Tissue Engineeri, Institute of Basic Medical Sciences School of Basic Medicine, Beijing, China

    Robert Chunhua Zhao

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© 2015 Shanghai Jiao Tong University Press, Shanghai and Springer Science+Business Media Dordrecht

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Mao, Y., Wang, Y., Wang, L., Zhou, Q. (2015). Induced Pluripotent Stem Cell, a Rising Star in Regenerative Medicine. In: Zhao, R. (eds) Stem Cells: Basics and Clinical Translation. Translational Medicine Research, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7273-0_4

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