Abstract
The most consistent feature of the migrating myoelectrical complex (MMC) of the small intestine of carnivores is its abolition by oral feeding1,2. Two studies3,4 have been published reporting the effects of exogenous pentagastrin on the fasting myoelectrical pattern; the resemblance of the effects of gastrin to the effects of food led both groups to suggest that endogenous gastrin is the agent responsible for the switch of pattern from fasting to feeding. The effects of cholecystokinin (CCK) on myoelectrical activity in the small intestine are less well-documented, but one recent study5 showed an effect of exogenous CCK similar to that of pentagastrin. Since CCK is also released by food, and is a structural analogue of gastrin, a similarity of action on digestive smooth muscle seems plausible.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Szurszewski, J. H. (1969). A migrating complex of the canine small intestine. Am. J. Physiol., 217, 1757
Code, C. F. and Marlett, J. A. (1975). The interdigestive myoelectric complex of the stomach and small bowel of dogs. J. Physiol., 246, 289
Weisbrodt, N. W., Copeland, E. M., Kearley, R. W., Moore, E. P. and Johnson, L. R. (1974). Effect of pentagastrin on the electrical activity of the small intestine of the dog. Am. J. Physiol., 227, 425
Marik, F. and Code, C. F. (1975). Control of the interdigestive myoelectric activity in dogs by the vagus nerve and pentagastrin. Gastroenterology, 69, 387
Mukhopadhyay, A. K., Thor, P. J., Copeland, E. M., Johnson, L. R. and Weisbrodt, N. W. (1977). Effect of cholecystokinin on myoelectric activity of small bowel of dog. Am. J. Physiol., 232, E44
Wingate, D. L., Barnett, T. G., Green, W. E. R. and Armstrong-James, M. A. (1977). Automated high-speed analysis of gastrointestinal myoelectric activity. Am. J. Dig. Dis., 22, 243
Barnett, T. G. and Wingate, D. L. (1977). The logical analysis of the canine electroenterogram. J. Physiol., 268, 14 P
Wingate, D. L., Thompson, H. H., Pearce, E. A. and Dand, A. (1977). Quantitative analysis of the effects of oral feeding on canine intestinal myoelectric activity. Gastroenterology, 72, 1151
Malagelada, J. R., Go, V. L. W. and Summerskill, W. H. J. (1973). Differing sensitivities of gallbladder and pancreas to cholecystokinin—pancreozymin in man. Gastroenterology, 64, 950
Carlson, G. M., Bedi, B. S. and Code, C. F. (1972). The mechanism of propagation of the intestinal interdigestive myoelectric complex. Am. J. Physiol., 222, 1027
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 Springer Science+Business Media New York
About this chapter
Cite this chapter
Wingate, D.L., Thompson, H.H., Pearce, E.A., Dand, A. (1978). The effects of exogenous cholecystokinin and pentagastrin on myoelectrical activity in the small intestine of the conscious fasted dog. In: Duthie, H.L. (eds) Gastrointestinal Motility in Health and Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-4389-1_7
Download citation
DOI: https://doi.org/10.1007/978-94-017-4389-1_7
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-017-4391-4
Online ISBN: 978-94-017-4389-1
eBook Packages: Springer Book Archive