Cycle control and modern contraception: some relevant aspects

  • M. J. Weijers


Literature data regarding cycle control of oral contraceptives are often unclear because of the lack of information on definitions concerning the evaluation of clinical trials. This frequently makes a valid comparison of results from different studies impossible. Information considered to be meaningful for practical purposes is discussed. Based on experience from multicentre trials with 14 000 women involving 180 000 cycles with combinations containing varying doses of a progestational and an oestrogenic substance, details are given about the role these active substances play in cycle control.

It is demonstrated that the progestational and oestrogenic components have independent influences on spotting and breakthrough bleeding. Predictions regarding cycle control, based only on the ratio progestogen to oestrogen, should not be made.


Oral Contraceptive Oral Contraception Modern Contraception Oestrogen Dose Breakthrough Bleeding 
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  1. 1.
    Vessey, M. (1982). Efficacy of different contraceptive methods. Lancet, 1, 841PubMedCrossRefGoogle Scholar
  2. 2.
    N.I.S.S.O. (Nederlands Instituut voor Sociaal Sexuologisch Onderzoek) (1975). Anticonceptiegedrag. Verslag van een onderzoek bij 1200 nederlandse vrouwen en mannen naar de wijze waarop men een zwangerschap probeert to voorkomen. (Report on an investigation in 1200 Dutch women and men with respect to their ways of preventing pregnancy). (Zeist: N.I.S.S.O. )Google Scholar
  3. 3.
    Orme, M. L. E. (1982). The clinical pharmacology of oral contraceptive steroids. Br. J. Clin. Pharmacol., 14, 31PubMedCrossRefGoogle Scholar
  4. 4.
    Fay, R. A. (1982). Failure with the new triphasic oral contraceptive Logynon. Br. Med. J., 284, 17CrossRefGoogle Scholar
  5. 5.
    Graham, H. (1982). Failure with the new triphasic oral contraceptive Logynon. Br. Med. J., 284, 422Google Scholar
  6. 6.
    Cullberg, G., et al. (1982). Two oral contraceptives, efficacy, serum proteins, and lipid metabolism. Contraception, 26, 229PubMedCrossRefGoogle Scholar
  7. 7.
    Cullberg, G. (1983). Säkerheten hos lagdoserade p-piller-metodfel en biverkning? (Reliability of low-dose contraceptive pill-method error a side effect?) Läkartidningen, 80, 2484Google Scholar
  8. 8.
    Johns Hopkins University (1982). Population Reports. Oral Contraceptives in the 1980s, Series A, No. 6, A189 - A221. ( Baltimore: Johns Hopkins University )Google Scholar
  9. 9.
    Briggs, M. H. and Briggs, M. (1981). Metabolic effects of oral contraceptives. In Fen, C. C., et al. (eds.). Recent Advances in Fertility Regulation. Proceedings of a symposium on recent advances in fertility regulation. Beijing 2–5 September 1980, pp. 83–111. ( Geneva: S. A. Atar )Google Scholar
  10. 10.
    Wiseman, R. A. and MacRae, K. D. (1981). Oral contraceptives and the decline in mortality from circulatory disease. Fertil. Steril., 35, 277PubMedGoogle Scholar
  11. 11.
    Kay, C. R. (1980). The happiness pill? J. R. Coll. Gen. Pract., 30, 8Google Scholar
  12. 12.
    Mishell, D. R. (1982). Noncontraceptive health benefits of oral steroidal contraceptives. Am. J. Obstet. Gynecol., 142, 809PubMedGoogle Scholar
  13. 13.
    Lachnit-Fixson, U. (1979). Erstes Dreistufenpraeparat zur hormonalen Konzeptionsverhuetung, Klinische Ergebnisse. Muench. Med, Wochenschr., 121, 1421Google Scholar
  14. 14.
    Woutersz, T. B. (1981). A low-dose combination oral contraceptive. J. Reprod. Med., 26, 615PubMedGoogle Scholar
  15. 15.
    Bergstein, N. A. M. (1976). Clinical efficacy, acceptability and metabolic effects of new low dose combined oral contraceptives. Acta Obstet. Gynecol. Scand. Suppl., 54, 51PubMedCrossRefGoogle Scholar
  16. 16.
    Upton, G. V. (1982). Clinical experience wits triphasics. Presented at the San Francisco Congress, October 17–22Google Scholar
  17. 17.
    Lawson, J. S. (1979). Optimum dosage of an oral contraceptive. Am. J. Obstet. Gynecol., 134, 315PubMedGoogle Scholar

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© Springer Science+Business Media New York 1984

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  • M. J. Weijers

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