Comparative haematological effects of new ethinyloestradiol-progestogen combinations
A randomized, prospective study on metabolic effects of three oral contraceptives is presented. The products used were a low-dose triphasic formulation of levonorgestrel (LNG) and ethinyloestradiol (EE), a fixed dose combination of 0.15 mg desogestrel (DOG) + 30μg EE, and a sequential formulation of 50μg EE (× 7), then 0.125 mg DOG + 50μg EE (×15). Over the initial six cycles significant changes were seen in coagulation and fibrinolytic factors in users of the sequential product, but much less with the other two products. Women using the sequential formulation were therefore switched to the triphasic product. After a further three cycles the laboratory tests showed restoration towards normality.
KeywordsOral Contraceptive Sequential Formulation Oral Contraception Fibrinolytic Factor Large Epidemiological Survey
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