Comparative haematological effects of new ethinyloestradiol-progestogen combinations

  • M. H. Briggs


A randomized, prospective study on metabolic effects of three oral contraceptives is presented. The products used were a low-dose triphasic formulation of levonorgestrel (LNG) and ethinyloestradiol (EE), a fixed dose combination of 0.15 mg desogestrel (DOG) + 30μg EE, and a sequential formulation of 50μg EE (× 7), then 0.125 mg DOG + 50μg EE (×15). Over the initial six cycles significant changes were seen in coagulation and fibrinolytic factors in users of the sequential product, but much less with the other two products. Women using the sequential formulation were therefore switched to the triphasic product. After a further three cycles the laboratory tests showed restoration towards normality.


Oral Contraceptive Sequential Formulation Oral Contraception Fibrinolytic Factor Large Epidemiological Survey 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Royal College of General Practitioners (1974). Oral Contraceptives and Health. ( London: Pitman )Google Scholar
  2. 2.
    Meade, T. W., Greenberg, G. and Thompson, S. C. (1980). Progestogens and cardiovascular reactions associated with oral contraceptives and a comparison of the safety of 50 and 30µg oestrogen preparations. Br. Med. J., i, 1157Google Scholar
  3. 3.
    Bottiger, L. E., Boman, G., Eklund, G. and Westerholm, B. (1980). Oral contraceptives and thromboembolic disease: effects of lowering oestrogen content. Lancet, 1, 1097PubMedCrossRefGoogle Scholar
  4. 4.
    Bergink, E. W., Hamburger, A. D., de Jager, E. and van der Vies, J. (1981). Binding of a contraceptive progestogen ORG 2969 and its metabolites to receptor proteins and human sex hormone binding globulin. J. Steroid Biochem., 14, 175PubMedCrossRefGoogle Scholar
  5. 5.
    Triplett, D. A. and Harms, C. S. (1981). Procedures for the Coagulation Laboratory. ( Chicago: American Society of Clinical Pathologists )Google Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • M. H. Briggs

There are no affiliations available

Personalised recommendations