Abstract
In the early days of modern toxicology, say about half a century ago, major goals of toxicity studies were the detection of the critical adverse effect of the chemical and the establishment of the dose-effect/response curve including the “No-Observed-Adverse-Effect-Level” (NOAEL). Starting from the overall NOAEL, using body weight for scaling up between experimental animals and humans, and applying uncertainty factors to compensate for intraand interspecies differences, a “safe” dose for humans was calculated. It is sad to observe that today too often we are still doing the same thing when recommending health-based exposure limits as the basis for setting standards.
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Feron, V.J. (2002). The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals. In: Krüse, J., Verhaar, H.J.M., de Raat, W.K. (eds) The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-3437-0_1
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DOI: https://doi.org/10.1007/978-94-017-3437-0_1
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