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A review of bioartificial liver development from an artificial organ engineering perspective

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Book cover The Hepatocyte Review

Abstract

Fulminant hepatic failure (FHF) and acute episodes in chronic liver failure are associated with high mortality [1–3]. Organ transplantation is the only treatment acknowledged to improve patient survival when compared with intensive care [4,5]. There is a shortage of donors worldwide [6–8] resulting in approximately 50% mortality amongst patients awaiting transplants [9]. Furthermore, OLT renders graft recipients dependent upon immunosuppression [10,11]. US hospital charges average $250,000 for liver transplants [12]. It was estimated that in the USA in 1996, there were approximately 1,700 emergency liver transplants with 1,000 patients dying while waiting for a transplant. A further 1,000 patients with FHF or sudden onset of acute liver failure (ALF) were either not listed for transplant or died before being listed [13].

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  1. Bioengineering Unit and Dept. Chemical and Process Engineering, University of Strathclyde, Glasgow, UK

    Mark D. Smith, M. Helen Grant, Rod B. Cousins & John D. S. Gaylor

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  1. Mark D. Smith
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  2. M. Helen Grant
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  3. Rod B. Cousins
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  4. John D. S. Gaylor
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Michael N. Berry Anthony M. Edwards

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Smith, M., Grant, M.H., Cousins, R.B., Gaylor, J.D.S. (2000). A review of bioartificial liver development from an artificial organ engineering perspective. In: Berry, M.N., Edwards, A.M. (eds) The Hepatocyte Review. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-3345-8_30

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