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The peritoneal microcirculation in peritoneal dialysis

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Textbook of Peritoneal Dialysis

Abstract

The peritoneal microcirculation is an intricate microvascular network through which physiological interactions occur between the systemic vasculature and the peritoneal cavity. In peritoneal dialysis these dynamic interactions are of paramount importance in maintaining effective dialysis. The peritoneal microcirculation participates in numerous physiological functions including solute transfer and exchange, regulation of fluid dynamics and ultrafiltration, delivery of nutrients and hormones, delivery of leukocytes to areas of inflammation and distribution of drugs. Physiological and pathophysiological changes, as well as the process of peritoneal dialysis, may affect many of these microvascular functions. The emphasis of this chapter will be to review available information regarding the peritoneal microcirculation and to integrate this information into a general functional knowledge as it relates to peritoneal dialysis. The chapter will examine: (1) the functional anatomy and blood supply of the peritoneum, (2) components of the peritoneal microvascular network, (3) peritoneal microvascular haemodynamics and the effects of vasoactive agents on the microcirculation and (4) inflammation in the peritoneal microcirculation with emphasis on leukocyte—endothelial interactions.

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Authors
  1. R. White
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  2. D. N. Granger
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Editor information

Editors and Affiliations

  1. Department of Renal Medicine, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK

    R. Gokal

  2. Division of Nephrology, Department of Medicine, MA 436 Health Services Centre, University of Missouri-Columbia, 65212, Columbia, MO, USA

    R. Khanna

  3. Academisch Medisch Centrum, Amsterdam, The Netherlands

    R. Th. Krediet

  4. Department of Internal Medicine, MA 436 Health Sciences Center, University of Missouri-Columbia, 65212, Columbia, MO, USA

    K. D. Nolph

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© 2000 Springer Science+Business Media Dordrecht

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White, R., Granger, D.N. (2000). The peritoneal microcirculation in peritoneal dialysis. In: Gokal, R., Khanna, R., Krediet, R.T., Nolph, K.D. (eds) Textbook of Peritoneal Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-3225-3_4

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  • DOI: https://doi.org/10.1007/978-94-017-3225-3_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-017-3227-7

  • Online ISBN: 978-94-017-3225-3

  • eBook Packages: Springer Book Archive

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