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The PIAS Protein Family and TC-PTP

Inhibiting STATs in the Nucleus

  • Chapter
Book cover Signal Transducers and Activators of Transcription (STATs)

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Abstract

The JAK-STAT signaling pathway can be negatively regulated at various steps. In the nucleus, tyrosine phosphorylated STATs bind to DNA to activate transcription. It has been suggested that the activity of STATs in the nucleus can be negatively regulated by two distinct mechanisms: the repression of STAT-dependent transcription by PIAS proteins and the dephosphorylation of STATs by nuclear protein tyrosine phosphatases (PTPases). This chapter is focused on the negative regulation of STATs in the nucleus.

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Author information

Authors and Affiliations

  1. Division of Hematology-Oncology, Department of Medicine; Department of Biological Chemistry, University of California, Los Angeles, CA, 90095, USA

    Bin Liu & Ke Shuai

Authors
  1. Bin Liu
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  2. Ke Shuai
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Editors and Affiliations

  1. New York University School of Medicine, USA

    Pravin B. Sehgal  & David E. Levy  & 

  2. Osaka University, Japan

    Toshio Hirano

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Liu, B., Shuai, K. (2003). The PIAS Protein Family and TC-PTP. In: Sehgal, P.B., Levy, D.E., Hirano, T. (eds) Signal Transducers and Activators of Transcription (STATs). Springer, Dordrecht. https://doi.org/10.1007/978-94-017-3000-6_6

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  • DOI: https://doi.org/10.1007/978-94-017-3000-6_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6421-9

  • Online ISBN: 978-94-017-3000-6

  • eBook Packages: Springer Book Archive

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