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Drug Discovery Approaches Targeting the JAK/STAT Pathway

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Signal Transducers and Activators of Transcription (STATs)

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Abstract

Efforts in molecular and cellular biology over the past two decades have resulted in the discovery and development of breakthrough drugs that have started to fulfill the promise of the biotechnology industry. In addition to products already on the market, large numbers of additional agents are in clinical trials, or awaiting approval. Moreover, with the revolution in genomic capabilities, the pace of target discovery has increased further which should lead to the discovery of many more therapeutically useful compounds with novel mechanisms of action.

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Authors and Affiliations

  1. Ligand Pharmaceuticals, San Diego, CA, 92121, USA

    Jonathan Rosen

  2. The Genomics Institute Novartis Research Foundation, San Diego, CA, 92121, USA

    H. Martin Seidel

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  1. H. Martin Seidel
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  1. New York University School of Medicine, USA

    Pravin B. Sehgal  & David E. Levy  & 

  2. Osaka University, Japan

    Toshio Hirano

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Seidel, H.M., Rosen, J. (2003). Drug Discovery Approaches Targeting the JAK/STAT Pathway. In: Sehgal, P.B., Levy, D.E., Hirano, T. (eds) Signal Transducers and Activators of Transcription (STATs). Springer, Dordrecht. https://doi.org/10.1007/978-94-017-3000-6_45

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  • DOI: https://doi.org/10.1007/978-94-017-3000-6_45

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