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Jak3 and the Pathogenesis of Severe Combined Immunodeficiency

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Signal Transducers and Activators of Transcription (STATs)

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Abstract

By the early 1990’s it had become abundantly clear that protein tyrosine kinases (PTK) were critical elements in growth and regulation of virtually all cell types. Impressed by the emerging importance of PTK in lymphocyte activation, it seemed likely that there might be a panoply of lymphoid-specific PTK that presumably would have critical functions in regulating immune responses. We thought it would be a good idea to try to get our hands on some of our own lymphoid-expressed kinases to study. Andrew Wilks’ PCR-based strategy for identifying novel PTK’s looked like an outstanding approach; Wilks, of course, had identified Jak1 and Jak2 using this method (1–4). At this point however, this was not what made an impression on us — who knew what these Jaks were anyway. The importance to us was that this was a rapid way of getting some kinases in hand.

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Authors and Affiliations

  1. Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, MD, 20892, USA

    Fabio Candotti

  2. Department of Pediatrics, University of Brescia, Brescia, Italy

    Luigi Notarangelo

  3. Department of Immunology, Queen’s University, Belfast, Belfast, Northern Ireland, UK

    James A. Johnston

  4. Laboratory of Experimental Immunology, National Cancer Institute, Frederick, MD, 21702, USA

    Daniel McVicar

  5. Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA

    John J. O’Shea

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  1. Fabio Candotti
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  2. Luigi Notarangelo
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  1. New York University School of Medicine, USA

    Pravin B. Sehgal  & David E. Levy  & 

  2. Osaka University, Japan

    Toshio Hirano

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Candotti, F., Notarangelo, L., Johnston, J.A., McVicar, D., O’Shea, J.J. (2003). Jak3 and the Pathogenesis of Severe Combined Immunodeficiency. In: Sehgal, P.B., Levy, D.E., Hirano, T. (eds) Signal Transducers and Activators of Transcription (STATs). Springer, Dordrecht. https://doi.org/10.1007/978-94-017-3000-6_39

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