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Introduction: A Brief History of the STATs and a Glance at the Future

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Signal Transducers and Activators of Transcription (STATs)

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Abstract

In the Spring of 1991 Chris Schindler and X.Y. Fu in our lab had succeeded in purifying sufficiently ISGF3, the interferon-α induced DNA binding complex that David Levy had identified, so that we had some hope of identifying the constituent protein(s). The sizes of the proteins in ISGF3 were identified in an experiment that Dan Kessler and I cooked up. Dan ran an EMSA with32P-labeled DNA and sufficient partially purified ISGF3 so that the labeled DNA and attached protein could be excised from the gel, the proteins eluted and run on a sizing gel revealing the presence of 91, 84, 113 and 48 kD molecules. He saw the same molecules in two separate experiments convincing us that this was correct.

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Author information

Authors and Affiliations

  1. Laboratory of Molecular Cell Biology, The Rockefeller University, New York, NY, 10021, USA

    James E. Darnell Jr.

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  1. James E. Darnell Jr.
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Editors and Affiliations

  1. New York University School of Medicine, USA

    Pravin B. Sehgal  & David E. Levy  & 

  2. Osaka University, Japan

    Toshio Hirano

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© 2003 Springer Science+Business Media Dordrecht

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Darnell, J.E. (2003). Introduction: A Brief History of the STATs and a Glance at the Future. In: Sehgal, P.B., Levy, D.E., Hirano, T. (eds) Signal Transducers and Activators of Transcription (STATs). Springer, Dordrecht. https://doi.org/10.1007/978-94-017-3000-6_1

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  • DOI: https://doi.org/10.1007/978-94-017-3000-6_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6421-9

  • Online ISBN: 978-94-017-3000-6

  • eBook Packages: Springer Book Archive

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