Abstract
Relaxin is a powerful dipsogen [1] and may be important in water balance in pregnancy. Neutralizing the action of endogenous relaxin within the ventricular system of the brain blocks the normal nighttime drinking response observed in pregnant rats [2] and there appears to be a differential response to central relaxin during pregnancy [3]. Evidence suggests that relaxin acts on the brain through the circumventricular organs, in particular the subfornical organ [4]. The central actions of relaxin are mediated through the angiotensin II receptors [5], which are also present in the subfornical organ. Therefore, experiments were done to investigate the possibility that the changing response to relaxin during pregnancy may be due to differential expression of the AT1 receptors in the subfornical organ.
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References
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© 2001 Springer Science+Business Media Dordrecht
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Summerlee, A.J.S., Poterski, R.S., Wilson, B.C. (2001). Effect of Relaxin on the Expression of Angiotensin II Receptors in the Subfornical Organ of Rats during Pregnancy. In: Tregear, G.W., Ivell, R., Bathgate, R.A., Wade, J.D. (eds) Relaxin 2000. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2877-5_31
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DOI: https://doi.org/10.1007/978-94-017-2877-5_31
Publisher Name: Springer, Dordrecht
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