Abstract
Circulating relaxin, like most (but not all) peptide hormones, probably does not readily pass across the blood-brain barrier. However, relaxin can exert influences on the brain, and in vitro autoradiographic binding [1] and physiological studies [2] suggest that it does this by binding to specific receptors in the subfornical organ and organum vasculosum of the lamina terminalis (OVLT), two circumventricular organs (CVOs) lacking a blood-brain barrier [3], that are situated in the anterior wall of the third cerebral ventricle. Included in the brain-mediated responses that circulating relaxin invokes are water drinking, as well as vasopressin and oxytocin secretion from the posterior pituitary [2].
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McKinley, M.J. et al. (2001). Neurons and neural pathways mediating the actions of circulating relaxin on the brain. In: Tregear, G.W., Ivell, R., Bathgate, R.A., Wade, J.D. (eds) Relaxin 2000. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2877-5_29
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DOI: https://doi.org/10.1007/978-94-017-2877-5_29
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