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Modulation of the Immune Response of the Immunosuppressed Host by Probiotics

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Probiotics 3

Abstract

An immunocompromised host is an immunodeficient host. The immunodeficiency disorders can be primary (genetically determined) which is rare occurring with a frequency of aproximately 1/50,000 or secondary induced by malnutrition, tumour growth, drug therapy (such as in autoimmunity or allergic illness) or by the strong immunosuppression associated with organ transplantation. In the immunosuppressed host the disorders may affect one or more components of the immune system including T and B cells and natural killer (NK) lymphocytes as well as phagocytic cells and the humoral immune response. The immunodeficiency is characterized by an increase in the suceptibility to infection, malignancy or defective tumour immunosurveillance.

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References

  • Abraham, R. and Ogra, P. (1993) Effect of intestinal microenviroment on mucosal immune response to viruses. In Immunophysiology of the Gut (eds. A. Walker, P. Harmatz and B. Wershil.), Academic Press, Inc. San Diego, USA, pp. 373–388.

    Google Scholar 

  • Agiiero, G., Sanchez, S., Fernandez, S., Allori, C., P.de Ruiz Holgado A. and Perdigón G. (1996) Administration of yoghurt or Lactobacillus casei to malnourished mice: comparative effect on lymphoid cells and mucosal reconditioning of the intestine, F. Agricult. Immunol, 8, 229–238.

    Article  Google Scholar 

  • Allori, C., Aguero, G., P.de Ruiz Holgado, A., M.de Nader, O. and Perdigón, G. (1999,in press) Gut mucosa morphology and microflora after renutrition with milk and administration of L. casei. J. Food Prot. 62.

    Google Scholar 

  • Anderson, M., Reynolds, S., You, M., Maronpot, R. (1992) Role of proto-oncogens activation in carcinogenesis, Environ. Health Persp., 98, 13–24.

    Article  CAS  Google Scholar 

  • Backer, S. and Backer, R. (1993) Enteric versus parenteral feeding and mucosal function. In Immunophysiology of the Gut, (eds. A. Walker, P. Harmatz and B. Wershil)Academic Press, Inc. San Diego, USA, pp. 401–414.

    Google Scholar 

  • Berg, R. (1981) Promotion of the translocation of enteric bacteria from the GI tracts of mice by oral treatment with penicillin, clindamycin or metronidazole, Infect. Immun., 33, 854–871.

    PubMed  CAS  Google Scholar 

  • Berg, R., Wommark, E. and Deitch, E. (1988) Immunosuppression and intestinal bacterial overgrowth synergistically promote bacterial translocation. Archives of Surgery, 123, 1359–1364.

    Article  PubMed  CAS  Google Scholar 

  • Bidoli, E., Franceschi, S. and Talamini, R. (1992) Food consumption and cancer of the colon and recturm in north-eastern Italy, Int. J. Cancer 50, 223–229.

    Article  PubMed  CAS  Google Scholar 

  • Birt, D Kris, E., Choe M. and Pelling, J. (1992) Dietary, energy, and fat effects on tumour promotion, Cancer Res,52, 2035 s-2039 s.

    Google Scholar 

  • Borgia, M., Sepe, N., Brancato, V. and Borgia, R. (1982) A controlled clinical study on Streptococcus faecium preparation for the prevention of side reactions during long term antibiotic therapy, Curr. Ther. Res. 31, 265–271.

    Google Scholar 

  • Bostick, R., Potter, J., Kushi, L., Sellers, T., Steinmetz, K., McKenzie, D., Gapstur, S. and Folsom, A. (1994) Sugar, meat, and fat intake and non-dietary risk factors for colon cancer incidence in Iowa women (United States), Cancer Res. 5, 38–52.

    CAS  Google Scholar 

  • Boudraa, G., Touhami, M., Pochart., P., Soltana, R., Mary, J and Desjeux, J., (1989) Effets comparés du yaourt et du lait sur la diarrhée persistante du nourrisson et de l’ enfant: résultats préliminaires. In Les laits Fermentés. Actualité de la Recherche, John Libbey Eurotext Ltd., pp. 229 - 232.

    Google Scholar 

  • Bugelski, P., Corwin, S., North, S., Kirsh, R., Nicolsanarid, G. and Poste, G. (1987) Macrophage content of spontaneous metastases at different stages of growth. Cancer Res. 47, 4141–4145.

    PubMed  CAS  Google Scholar 

  • Buts, J., Corthier, G. and Delmée, M. (1993) Saccharomyces boulardii for Clostridium difficile associated enteropathies in infants, J. Pediatr. Gastroenterol. 16, 419–425.

    Article  CAS  Google Scholar 

  • Chandra, R. and Wadhwa, M. (1993) Nutritional deficiences and intestinal mucosal immunity. In Immunophysiology of the Gut, (eds. A. Walker, P. Harmatz and B. Wershil ), Academic Press, Inc. San Diego, USA, pp. 389–399.

    Google Scholar 

  • Chyou, P., Momura, A. and Stemmermann, G. (1993) A prospective study of diet, smoking, and lower urinary tract cancer, Ann. Epidemiol. 3, 211–216.

    Article  PubMed  CAS  Google Scholar 

  • Claman, H. (1983) Glucortids I anti-inflammatory mechanisms. II the clinical response. Hosp. Pract, 18, 123–135.

    CAS  Google Scholar 

  • Cohen, J. and Duke, R. (1984) Glucocorticoid activation of a calcium dependent endonuclease in thymocyte nucleid lead to cell death, J. Immunol. 132, 38–43.

    PubMed  CAS  Google Scholar 

  • Corthier, G. (1997) Antibiotic-associated diarrhoea: treatments by living organisms given by the oral route (probiotics). In Probiotics 2: Applications and Practical Aspects. (ed. R. Fuller) Chapman and Hall, London, pp. 40–64.

    Google Scholar 

  • De Simone, C., Bianchi Salvadori, B., Jirillo, E., Baldinelli, L., Di Fabio, S. and Vesely, R. (1989) Yogurt and the immune response. in Les laits Fermentés. Actualité de la Recherche,John Libbey Eurotext Ltd., pp. 63–67.

    Google Scholar 

  • De Simone, C., Bianchi-Salvadori, R., Negri, R., Ferrazi, M., Boldinelli, L. and Vessely, R. (1986) The adjuvant effect of yogurt on production of gamma-interferon by Con A- stimulated human peripheral blood lymphocytes, Nutr. Rep. Intern, 33, 419–433.

    Google Scholar 

  • Fransceschi, S., Bidoli, E., Baron, A. and LaVecchia, C. (1990) Maize and risk of cancers of the oral cavity, pharynx and esophagus in northern Italy,JNCI, 82, 1407–1411.

    Google Scholar 

  • Fukuda, K., Shibata, A., Hirohata, I., Tanikawa, K., Yamaguchi, G., and Ishii, M. (1993) A hospital-based case-control study on hepatocellular carcinoma in Fukuoka and Saga prefectures, Northerm Kyushu, Japan, Jpn. J. Cancer Res. 84, 708–714.

    Article  PubMed  CAS  Google Scholar 

  • Fuller, R. (1997) Introduction. In Probiotics 2: Applications and Practical Aspects, (ed.R.Fuller), Chapman and Hall, London, pp. 1–9.

    Google Scholar 

  • Gotz, V., Romankiewics, J., Mose, J. et al. (1979) Prophylaxis against ampicillinassociated diarrhoea with a Lactobacillus preparation, Am. J. Hosp. Pharm,36 754–757.

    Google Scholar 

  • Hague, A., Elder, D., Hicks, D. and Paraskeva, C. (1995) Apoptosis in colorectal tumour cells: induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate, Int. J. Cancer, 60, 400–406

    Article  PubMed  CAS  Google Scholar 

  • Harris, C. (1991) Chemical and physical carcinogenesis: advances and perspectives for the 1990’s, Cancer Res. (Suppl) 51, 5023 s-5044 s.

    Google Scholar 

  • Harris, C. (1993) At the crossroads of molecular carcinogenesis and risk assessment, Science, 262, 1980–1981.

    Article  PubMed  CAS  Google Scholar 

  • Hising, A., Guo, W., Chen, J., Stone, B., Blot, W. and Fraumeni, C. (1991) Correlates of liver cancer mortality in China, Int. J. Epidemiol. 20, 54–59.

    Article  Google Scholar 

  • Issacson, P. (1982) Immunoperoxidase study of the secretory immunoglobulin system in colonic neoplasia, J. Clin. Pathol. 35, 14–25.

    Article  Google Scholar 

  • Kampman, E., Goldbohm, A., van den Brandt, P. and van’t Veer, P. (1994) Fermented dairy products, calcium and colorectal cancer in the Netherlands cohort study, Cancer Res. 54, 3186–3190.

    PubMed  CAS  Google Scholar 

  • Kato, I., Miura, S., Kasumi, F., Iwase, T., Tashiro, H. et al. (1992) A case-control study of breast cancer among japanese women: with special reference to family history and reproductive and dietary factors, Breast Cancer Research Treatment, 24, 51–59.

    Article  CAS  Google Scholar 

  • Katosouyanni, K., Trichopoulos, D. and Boyle, P. (1986) Diet and breast cancer: a case-control study in Greece, Int J. Cancer 38, 815–820.

    Article  Google Scholar 

  • Kayser, H. and Meise, H. (1996) Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins, FEBS Letters, 383, 18–20.

    Article  PubMed  CAS  Google Scholar 

  • Koldovsky, O. (1989) Hormones in milk: their possible physiological significance for the neonate. In Gastroenterology and Nutrition in Infancy, (ed. E. Lebenthal ), Raven Press, New York, pp. 97–119.

    Google Scholar 

  • Kong, W., Koldovsky, O. and Rao, R. (1992) Appearance of exogenous epidermal growth factor in liver, bile and intestinal lumen of suckling rats, Gastroenterology, 102, 661–667.

    PubMed  CAS  Google Scholar 

  • LaVecchia, C., Negri, E. and D’Avanzo, B. (1991) Dietary indicators of oral and pharyngeal cancer, Int. J. Epidemiol., 20, 39–44.

    Article  PubMed  Google Scholar 

  • LaVecchia, C., Negri, E., Decarli, A., D’ Avanzo, B. and Franceschi, S. (1988) Risk factors for hepatocellular carcinoma in northern Italy, Int. J. Cancer, 42, 872 - 876.

    Article  PubMed  Google Scholar 

  • Lee, H., Gourley, L. and Duffy, S. (1989) Colorectal cancer and diet in an Asian population a case control study among Singapore Chinese, Int. J Cancer, 43, 1007–1016.

    Article  PubMed  CAS  Google Scholar 

  • Lise,L.and Audibert, F. (1989) Immunoadjuvants and analogs of immunomodulatory bacterial structures, Current Opinion in Immunology, 2, 269–274.

    Article  PubMed  CAS  Google Scholar 

  • Lunn, P.G., Northrop-Clewes, C. and Downes, R. (1991) Intestinal permeability, mucosal injury and growth faltering in gambian infants, Lancet 338, 907–910.

    Article  PubMed  CAS  Google Scholar 

  • Mac Dermott, R. (1993) Effect of nutritional factors and the microenviroment on mucosal immune function. In Immunophysiology of the Gut, (eds. A. Walker, P.Harmatz and B. Wershil), Academic Press, Inc. San Diego, USA, pp. 365–371.

    Google Scholar 

  • Macquart-Moulin, G., Riboli, E. and Cornje, J. (1986) Case-control study on colorectal cancer diet in Marseilles, Int, J. Cancer 38, 183–191.

    CAS  Google Scholar 

  • Manousos, O., Day, N., Trichopoulos, D. (1983) Diet and colorectal cancer: A case-control study in Greece, Int. J. Cancer, 32, 1–5.

    Article  PubMed  CAS  Google Scholar 

  • McLaughlin, J., Gridley, G., and Block, G. (1988) Dietary factors in oral and pharyngeal cancer, J. Natl. Cancer Inst., 80, 1237–1243.

    Article  PubMed  CAS  Google Scholar 

  • Meuth, M. (1989) The molecular basis of mutations induced by deoxynucleotide triphosphate pool imbalances in mammalian cells, Exp. Cell Res., 181, 305–316.

    Article  PubMed  CAS  Google Scholar 

  • Mils, P., Beeson, W., Phillips, R. and Fraser, G. (1991) Bladder cancer in a low risk population: results from the adventist health study, Am. J. Epidemiol. 133, 230–239.

    Google Scholar 

  • Munck, A. and Crabtree, G. (1981) Glucocorticoid induced lymphocyte death. In Biology and Pathology, (eds. I. Bowen. and R. Lockshin ), Chapman and Hall, New York pp. 329–359.

    Google Scholar 

  • Nardi, R., Vierira, E. and Crocco-Alfonso, L. (1990) Experimental salmonellosis in conventional and germ-free mice. Bacteriological and immunological aspects. Program and Abstracts 10` h Symposium on Gnotobiology, pp. 27–34.

    Google Scholar 

  • Newberne, P. and Rogers, A. (1986) The role of nutrients in cancer causation. In Diet, Nutrition, and Cancer, (ed. Y. Hayashi ), Japan Scientific Press, pp. 205–222.

    Google Scholar 

  • Newmark, H. and Lipkin, M. (1992) Calcium, Vitamin D and colon cancer, Cancer Res.52, 2067 s- 2070 s.

    Google Scholar 

  • Notani, P. and Jayant, K. (1987) Role of diet in upper aerodigestive tract cancers, Nutr. Cancer, 10, 103–111

    Article  PubMed  CAS  Google Scholar 

  • Perdigón, G., Agüero, G., Alvarez, S., Gaudioso de Allori, C. and P.de Ruiz Holgado, A. (1995 a) Effect of viable Lactobacillus casei feeding on the immunity of the mucosae and intestinal microflora in mal-nourished mice, Milchwiss. 50, 251–256.

    Google Scholar 

  • Perdigón, G., Alvarez, S., Rachid, M., Agüero, G. and Gobbato, N. (1995 b) Immune system stimulation by Probiotics, J. Dairy Sci 78 1597–1606.

    Google Scholar 

  • Perdigón, G., Alvarez, S., Valdez, J. and Rachid, M. (1996) Effect of feeding Lactobacillus casei, Lactobacillus acidophilus and yogurt on the secretory immune system. In Proceedings: “Yogurt: Myth versus Reality” Conference, (ed. D. Curtis)Published in the United States of America by National Yogurt Association, pp. 65–76.

    Google Scholar 

  • Perdigon, G., B.B.de Jorrat, M. E., Petrino, S. de, and Rachid, M. (1993 a) Antitumour activity of orally administered Lactobacillus casei: Significance of its dose in the inhibition of a fibrosarcoma in mice, F. Agricult. Immunol 5, 39–49.

    Article  CAS  Google Scholar 

  • Perdigón, G., B.B.de Jorrat, M.E., Valdez, J., Budeguer, M. de and Oliver, G. (1995 c) Cytolytic effect of the serum of mice fed with Lactobacillus card on tumour cells, Microbiol. Alim. Nutr 13, 15–24.

    Google Scholar 

  • Perdigón, G., Medici, M., B.B.de Jorrat, M.E., Valverde de Budeguer, M. and Pesce de Ruiz Holgado, A. (1993 b) Immunomodulating effects of lactic acid bacteria on mucosal and tumoral immunity, Int. J. Immunotherapy IX, 29–52.

    Google Scholar 

  • Perdigón, G., Valdez, J. and Rachid, M. (1998) Antitumour activity of yogurt: study of possible immune mechanisms, J. Dairy Res 65, 129–138.

    Article  PubMed  Google Scholar 

  • Pereyra, B FalcoffR., Falcoff, D. and Lemmonier, D. (1989) Production d’ interférons chez la souris par les bactéries lactiques du yaourt. In Les laits Fermentés. Actualité de la Recherche,John Libbey Eurotext Ltd., pp. 69–76.

    Google Scholar 

  • Petrino, S. de, B. B. de Jorrat, M. E., Meson, O. and Perdigón, G. (1995) Protective ability of certain lactic acid bacteria against an infection with Candida albicans in a mouse immunosuppression model by corticoid, Fd. Agricult. Immunol., 7, 365–373.

    Article  Google Scholar 

  • Petrino, S. de, B. B.de Jorrat, M.E., de Budeguer, M. and Perdigón, G. (1997) Influence of the oral administration of different lactic acid bacteria on intestinal microflora and IgA-secreting cells in mice treated with ampicillin,, Fd Agricult. Immunol., 9, 265–275.

    Article  Google Scholar 

  • Petrino, S. de, B.B. de Jorrat, M.E. and Perdigón, G. (1996) Effect of different lactic acid bacteria on immune response in corticoid immunosuppressed mice. Microbiol. Alien. Nutr., 14, 227–236.

    Google Scholar 

  • Pitot, H., Dragan, Y. (1994) The multistage nature of chemically induced hepatocarcinogenesis in the rat, Drug Metab.Rev. 26, 209–220.

    Article  PubMed  CAS  Google Scholar 

  • Poirier, L. (1987) Stages in carcinogenesis: alteration by diet, J. Clin Nutr. 45, 185–190.

    CAS  Google Scholar 

  • Poirier, L., Newberne, P. and Pariza, M. (1986) Essential Nutrients in Carcinogenesis, New York: Plenum Press.

    Google Scholar 

  • Roux, M. and Lopez, M. (1987) Impairment of IgA expression and cell mediated immunity observed on Peyer’s patch protein-depleted rats at weaning and then fed on 20% casein, Recent Adv. Exp. Med Biol., 216 A, 847–855.

    Google Scholar 

  • Roux, M., Slobodianik, N., Cosaninsky, R., Langini, S. and Sanahuja, Y. (1983) Effect of severe protein deficiency on the expression of surface and intracellular markers of lymphoid organs in growing rats, Comunicaciones Biologicas, 2, 175–181.

    CAS  Google Scholar 

  • Salminen, S. and Deighton, M. (1992) Lactic acid bacteria in the gut in normal and disordered states. In Digestive Diseases (eds. T. Chen, N. East Orange) Karger, Basel, pp. 227–238.

    Google Scholar 

  • Siitonen, S., Vapaatalo, H., Salminen, S. et al (1990) Effect of Lactobacillus GG yogurt in prevention of antibiotic associated diarrhoea, Am. Med. 22: 57–59.

    CAS  Google Scholar 

  • Spector, S. and Hadden, J. (1988) Immunopharmacology basis of immunotherapy to correct T cell deficiences. In Advances in Immunomodulation, (eds. B. Bizzini and S. Bonasar ), Pythagorz Press, Rome-Milan, Italy, pp. 363–370.

    Google Scholar 

  • Steinmetz, K. and Potter, J. (1991) A review of vegetables, fruit, and cancer II: Mechanisms, Cancer Causes Control, 2 427–442.

    Article  PubMed  CAS  Google Scholar 

  • Sullivan, D. and Wira C. (1983 a) Variations in free secretory component levels in mucosal secretions of the rat, J. Immunol, 130, 1330–1335.

    Google Scholar 

  • Sullivan, D. and Wira, C. (1983 b) Hormonal regulation of immunoglobulins in the rat uterus: uterine response to multiple estradiol treatment, Endocronology, 112, 260–268.

    Google Scholar 

  • Sullivan, P.B., Marsh, M., Mirakian, R., Hill, S., Mila, P. and Neale, G. (1991) Cronic diarrhea and malnutrition: Histology of the small intestinal lesion, J. Pediatric Gastroenterol. Nutr., 12, 195–203.

    Article  CAS  Google Scholar 

  • Tirelli, A., De Noni, I. and Resmini (1997) Bioactive peptides in milk products, Ital. J. Food Sci., 2, 91–98.

    Google Scholar 

  • Tuyns, A., Kaaks, R. and Haelterman, M. (1988) Colorectal cancer and the consumption of foods: a case-control study in Belgium, Nutr. Cancer 11, 189–204.

    Article  PubMed  CAS  Google Scholar 

  • Tuyns, A., Riboli, E., and Doombos, G. (1987) Diet and esophageal cancer in Calvadas (France), Nutr. Cancer, 9, 81–92.

    Article  PubMed  CAS  Google Scholar 

  • Valdez, J., Rachid, M., Bru, E. and Perdigón, G. (1997) The effect of yoghurt on the cytotoxic and phagocytic activity of macrophages in tumour-bearing mice, Fd. Agricult. Immunol. 9, 299–308.

    Article  Google Scholar 

  • Wattenberg, L. (1992) Inhibition of carcinogenesis by minor dietary constituents, Cancer Res, 52, 2085 s-2091 s.

    Google Scholar 

  • Wira, Ch., and Prabhala, R. (1993) Sex hormone, glucorticoid and cytokine regulation of mucosal immunity: hormonal influences on antibody levels and antigen presentation in the female genital tract. In Immunophysiology of the Gut, (eds. A. Walker, P. Harmatz and B. Wershil ), Academic Press, Inc. 13, 183–205.

    Google Scholar 

  • Zheng, W., Blot, W. and Shu, X. (1992) Risk factors for oral and pharyngeal cancer in Shanghai, with emphasis on diet cancer, Epidemiol. Biomarkers Prov., 1, 441–448.

    CAS  Google Scholar 

  • Ziegler, R., Brinton, L. and Hamman, R. (1990) Diet and risk of invasive cervical cancer among white women in the United States, Am. J. Epidemiol. 132, 432–445.

    PubMed  CAS  Google Scholar 

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  1. G. Perdigón
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  2. G. Oliver
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Editors and Affiliations

  1. Gut Microecology, 59 Ryeish Green, Three Mile Cross, RG7 1ES, Reading, UK

    R. Fuller (Freelance Consultant) (Freelance Consultant)

  2. Tucumán University, Argentina

    G. Perdigon (Professor of Immunology) (Professor of Immunology)

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Perdigón, G., Oliver, G. (2000). Modulation of the Immune Response of the Immunosuppressed Host by Probiotics. In: Fuller, R., Perdigon, G. (eds) Probiotics 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2768-6_6

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  • DOI: https://doi.org/10.1007/978-94-017-2768-6_6

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