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Multiple Drug Resistance in Cancer 2 pp 71–79Cite as

Membrane topology of the human multidrug resistance-associated protein (MRP) and its homologs

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Abstract

The discovery of the human multidrug resistance-associated protein (hMRP) involved in conferring a multidrug resistant phenotype to tumor cells by Cole et al.,1992 [1], was a landmark in our improved understanding of the molecular basis of multidrug resistance. It subsequently became clear that the majority of non-P-glycoprotein mediated multidrug resistance is due to the overexpression of hMRP. The clinical importance and the functional characteristics of this transporter have been the subject of several reviews in recent years [2–5], and according to our current understanding hMRP probably transports both hydrophobic anticancer agents and anionic (e.g. glutathione) drug conjugates, and its physiological functioning may provide a wide range of cellular xenobiotic resistance [1,6–9].

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Author information

Authors and Affiliations

  1. Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, H-1113, Budapest, Hungary

    András Váradi, Gábor E. Tusnády & Éva Bakos

  2. National Institute of Haematology and Immunology, Membrane Research Group of the Hungarian Academy of Sciences, H-1113, Budapest, Hungary

    Balázs Sarkadi

Authors
  1. András Váradi
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  2. Gábor E. Tusnády
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  3. Éva Bakos
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  4. Balázs Sarkadi
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Corresponding author

Correspondence to András Váradi .

Editor information

Editors and Affiliations

  1. National Cell & Tissue Center, Bioresearch Ireland, Dublin City University, Glasnevin, Dublin, Ireland

    Martin Clynes

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© 1998 Springer Science+Business Media Dordrecht

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Váradi, A., Tusnády, G.E., Bakos, É., Sarkadi, B. (1998). Membrane topology of the human multidrug resistance-associated protein (MRP) and its homologs. In: Clynes, M. (eds) Multiple Drug Resistance in Cancer 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2374-9_4

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  • DOI: https://doi.org/10.1007/978-94-017-2374-9_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5108-0

  • Online ISBN: 978-94-017-2374-9

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