Abstract
The use of transgenic plants expressing autoantigens to induce protective oral immune tolerance represents a novel approach for antigen-specific therapy of autoimmune disease. A transgenic plant-based strategy offers several attractive advantages for oral tolerance, including relatively inexpensive production of large amounts of soluble protein antigens essential for the clinical application of oral tolerance, and absence of potential pathogens and endotoxins which are issues in the production of therapeutic proteins from animal tissues or bacterial cells. Plants also offer a simple and efficient system for the direct oral delivery of human proteins for immune modulation which in many cases will not require extensive and expensive protein purification steps. Here we discuss strategies to prevent autoimmune diabetes by oral delivery of diabetes-associated autoantigens such as glutamic acid decarboxylase (GAD) and insulin in transgenic plants. These principles and approaches may be relevant to other clinical indications such as transplant rejection, allergy and the delivery of bio-therapeutics in inflammatory bowel disease.
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Ma, S., Jevnikar, A.M. (2002). Suppression of Autoimmune Diabetes by the Use of Transgenic Plants Expressing Autoantigens to Induce Oral Tolerance. In: Erickson, L., Yu, WJ., Brandle, J., Rymerson, R. (eds) Molecular Farming of Plants and Animals for Human and Veterinary Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2317-6_8
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DOI: https://doi.org/10.1007/978-94-017-2317-6_8
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