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The Production of Recombinant Cytokines in Plants

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Molecular Farming of Plants and Animals for Human and Veterinary Medicine

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Abstract

Cytokines are soluble, secreted glycoproteins that, like hormones, regulate the functions of cells and tissues. Many cytokines possess therapeutic properties and attempts to produce them in large quantities are ongoing. Transgenic plants are one system that has the potential to yield large amounts of low cost recombinant proteins. In addition, plants have the ability to introduce post-translational modifications needed for biological activity of many cytokines. In this review, we describe the efforts aimed at producing recombinant cytokines in plants and discuss some of the issues that have arisen from such activities.

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Authors and Affiliations

  1. Southern Crop Protection and Food Research Centre, Agriculture and Agri-Food Canada, 1391 Sandford St., London, Ontario, N5V 4T3, Canada

    R. Menassa & J. Brandle

  2. MOTS -Transplantation and Immunobiology Group, London Health Sciences Centre, 339 Windermere Road, London, Ontario, N6A 5A5, Canada

    A. Jevnikar

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  1. R. Menassa
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Editors and Affiliations

  1. Department of Plant Agriculture, University of Guelph, Geulph, Ontario, Canada

    L. Erickson

  2. Syngenta Biotechnology Inc., Research Triangle Park, North Carolina, USA

    W.-J. Yu

  3. Research Branch, Agriculture and Agri-Food Canada, London, Ontario, Canada

    J. Brandle  & R. Rymerson  & 

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Menassa, R., Jevnikar, A., Brandle, J. (2002). The Production of Recombinant Cytokines in Plants. In: Erickson, L., Yu, WJ., Brandle, J., Rymerson, R. (eds) Molecular Farming of Plants and Animals for Human and Veterinary Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2317-6_14

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  • DOI: https://doi.org/10.1007/978-94-017-2317-6_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6110-2

  • Online ISBN: 978-94-017-2317-6

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