Abstract
The advantages of microreactors or microcomponents for unit operations are generally acknowledged today. Promising economical and ecological aspects result from increased selectivities and yields as well as from low specific energy consumption. Large surface area to volume ratios, high gradients of temperature, pressure, concentration and density as well as short response times and pathways characterize typical process engineering aspects of such microdevices. The possibility to integrate a large number of microunits within a comparatively small space opens up two major fields of application. Firstly, production of chemicals, especially fine chemicals, on-site and on-demand can be achieved in a continuous process when a large number of identical units is operated in parallel. Secondly, combinatorial synthesis and high throughput screening can be performed with high efficiency in the field of lead discovery and catalyst development, respectively, when microunits with different functions or different educts are applied. This field of application aims at the generation of a huge amount of information about the properties and interactions of substances. A variety of three-dimensional microfabrication processes, applicable to a diversity of materials, meanwhile allows cheap mass production of microreactors and microreactor components.
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References
W. Ehrfeld, K. Golbig, V. Hessel, H. Löwe, Th. Richter, „Characterization of mixing in micromixers by a test reaction: Single mixing units and mixer arrays“, Ind. Eng. Chem. Res., 38, (1999) 1075.
K. Schubert, W. Bier, J. Brandner, M. Fichtner, C. Franz, G. Linder, „Realization and testing of microstructure reactors, micro heat exchangers and micromixers for industrial applications in chemical engineering“, in W. Ehrfeld, I. H. Rinard, R. S. Wegeng (Eds.) Process miniaturization: 2nd International Conference on Microreaction Technology; Topical Conferences Preprints, AIChE, New Orleans, LU, (1998).
K. Kadel, F. Götz, R. P. Peters, “Cross-flow filter made using deep dry etching” in W. Ehrfeld, I. H. Rinard, R. S. Wegeng (Eds.) Process miniaturization: 2nd International Conference on Microreaction Technology; Topical Conferences Preprints, AIChE, New Orleans, LU, (1998).
I. Robins, J. Shaw, B. Miller, C. Turner, M. Harper, “Solute transfer by liquid l liquid exchange without mixing in micro-contactor devices” in W. Ehrfeld (Ed.) Microreaction Technology, Proceedings of the 1st International Conference on Microreaction Technology, Springer Verlag, Berlin, (1997).
Th. Richter, W. Ehrfeld, T. Hang, H. Löwe, J. Schiewe, X. L. Yan, A. A. Kurganov, K. Unger, “Integrated heating and cooling module for miniaturized fast GC-analysis”, Proceedings of the 4 h International Conference on Microreaction Technology, 5–9 March, 2000, Atlanta, USA.
W. Ehrfeld, V. Hessel, S. Kiesewalter, H. Löwe, Th. Richter, J. Schiewe, “Implementation of Microreaction Technology in Process Engineering and Biochemistry” in W. Ehrfeld (Ed.) Microreaction Technology: 40 Conference on Microreaction Technology, Proceedings of IMRET 3,Springer Verlag, (2000), in press.
H. Löwe, W. Ehrfeld, V. Hessel, Th. Richter, J. Schiewe, “Micromixing Technology”, Proceedings of the 4 th International Conference on Microreaction Technology, 5–9 March, 2000, Atlanta, USA.
W. Ehrfeld, V. Hessel, V. Haverkamp, “Microreactors”, Ullmann’s Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, (1999).
W. Ehrfeld, V. Hessel, H. Löwe, “Extending the Knowledge Base in Microfabrication towards Chemical Engineering and Fluiddynamic Simulation”, Proceedings of the 4th International Conference on Microreaction Technology, 5–9 March, 2000, Atlanta, USA.
Th. Richter, W. Ehrfeld, A. Wolf, H.-P. Gruber, O. Wörz, “Fabrication of microreactor components by electro discharge machining” in W. Ehrfeld (Ed.) Microreaction Technology, Proceedings of the 1 St International Conference on Microreaction Technology, Springer Verlag, Berlin, (1997).
V. Hessel, W. Ehrfeld, K. Golbig, V. Haverkamp, H. Löwe, M. Storz, Ch. Wille, A. Gruber, K. Jänisch, M. Baerns, “Gas/Liquid Microreactors for Direct Fluorination of Aromatic Compounds Using Elemental Fluorine” in W. Ehrfeld (Ed.) Microreaction Technology: 3 nd International Conference on Microreaction Technology, Proceedings of IMRET 3, Springer Verlag, (2000), in press.
Th. Richter, W. Ehrfeld, K. Gebauer, K. Golbig, V. Hessel, H. Löwe, A. Wolf, “Metallic microreactors: Components and integrated systems” in W. Ehrfeld, I. H. Rinard, R. S. Wegeng (Eds.) Process miniaturization: 2nd International Conference on Microreaction Technology; Topical Conferences Preprints, AIChE, New Orleans, LU, (1998).
Th. Richter, W. Ehrfeld, D. Emtner, K. Gebauer, K. Golbig, O. Hausner, H. Löwe, A. Lange de Oliveira, W. Schmidt, F. Schüth, “Microstructured reactor for consecutive heterogeneous/homogeneous gas phase reactions” in W. Ehrfeld (Ed.) Microreaction Technology: 3 nd International Conference on Microreaction Technology, Proceedings of IMRET 3, Springer Verlag, (2000), in press.
T. Zech, D. Hönicke, A. Lohf, K. Golbig, T. Richter, “Simultaneous screening of catalysts in microchannels: Methodology and experimental set-up” in W. Ehrfeld (Ed.) Microreaction Technology: 3 nd International Conference on Microreaction Technology, Proceedings of IMRET 3, Springer Verlag, (2000), in press.
H. Becker, W. Ehrfeld, R. Pommersheim, “Multichannel Arrays on Polymer Substrates — Towards a Disposable Proteomics Chip”, Design, Test, and Microfabrication of MEMS and MOEMS (1999) 728–733.
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Ehrfeld, W., Hartmann, HJ., Hessel, V., Kiesewalter, S., Löwe, H. (2000). Microreaction Technology for Process Intensification and High Throughput Screening. In: van den Berg, A., Olthuis, W., Bergveld, P. (eds) Micro Total Analysis Systems 2000. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2264-3_7
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DOI: https://doi.org/10.1007/978-94-017-2264-3_7
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