Abstract
1-(2-Nitro-1-imidazolyl)-3-fluoro-2-propanol, FMISO (1), was suggested as a tracer for the determination of hypoxic tissue in vivo with PET in 19841. Since then, several synthetic approaches to FMISO have been undertaken with the aim of serving clinical applications. Though the focus has been on FMISO production, the development of other alternative hypoxia tracers has merit, based on pursuit of simpler synthetic methods or the long range goal of discovering new tracers that act biologically under less severe hypoxic conditions.
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Grierson, J., Patt, M. (1999). Syntheses of PET-Tracers for the Determination of Hypoxia. In: Machulla, HJ. (eds) Imaging of Hypoxia. Developments in Nuclear Medicine, vol 33. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-1828-8_5
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DOI: https://doi.org/10.1007/978-94-017-1828-8_5
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