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Helicobactor pylori pp 413–422Cite as

Novel targets for Helicobacter pylori eradication

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Abstract

The finding that Helicobacter pylori infected the human stomach and induced a pathological response not only revolutionized concepts as to causation of peptic ulcer disease and gastric cancer, but raised a question as to the nature of the organism able to colonize the gastric surface1–3. Understanding more about this group 1 carcinogen should enable simpler, more selective and more effective eradication therapy worldwide. It is perhaps unfortunate that duodenal ulcer is declining in the Western world, resulting in a loss of interest in means of eradication among the major pharmaceutical companies. Here we therefore present concepts that might illuminate specific drug targets in H. pylori essential for survival in the stomach, but perhaps not in an in-vitro neutral pH environment.

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Authors
  1. G. Sachs
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  2. Y. Wen
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  3. D. Weeks
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  4. E. A. Marcus
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  5. D. R. Scott
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Editor information

Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, L8N 3Z5, Hamilton, Ontario, Canada

    Richard H. Hunt (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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© 2003 Springer Science+Business Media Dordrecht

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Sachs, G., Wen, Y., Weeks, D., Marcus, E.A., Scott, D.R. (2003). Novel targets for Helicobacter pylori eradication. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobactor pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-1763-2_43

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  • DOI: https://doi.org/10.1007/978-94-017-1763-2_43

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5778-5

  • Online ISBN: 978-94-017-1763-2

  • eBook Packages: Springer Book Archive

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