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Helicobacter pylori eradication in non-ulcer dyspepsia: the case for

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Helicobactor pylori

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Abstract

Upper gastrointestinal symptoms have troubled patients for centuries. Until recent years the options left open to clinicians were severely limited and centred mainly on special diets and antacids1. The discovery of Helicobacter pylori infection and antibiotic combinations that eradicate the infection has led to cure of most peptic ulcer disease2 whilst proton pump inhibitors (PPI) have proved effective therapy for the symptoms of gastro-oesophageal reflux disease3. Peptic ulcer and gastro-oesophageal reflux disease account for about half of patients with upper gastrointestinal symptoms, with non-ulcer dyspepsia (NUD) responsible for the remaining 50%4. It is the treatment of NUD that has proved most resistant to clinical research. The cause of this disorder is uncertain but it is likely to be multifactorial with evidence of poor gastric accommodation, hypomotility and hyperalgesia5. The multi-factorial nature of NUD suggests that one therapy is unlikely to cure all patients and any intervention is going to achieve success in only a proportion of patients.

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Authors
  1. P. Moayyedi
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Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, L8N 3Z5, Hamilton, Ontario, Canada

    Richard H. Hunt (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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© 2003 Springer Science+Business Media Dordrecht

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Moayyedi, P. (2003). Helicobacter pylori eradication in non-ulcer dyspepsia: the case for. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobactor pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-1763-2_27

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  • DOI: https://doi.org/10.1007/978-94-017-1763-2_27

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5778-5

  • Online ISBN: 978-94-017-1763-2

  • eBook Packages: Springer Book Archive

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