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Role of interleukin-1 beta and other potential genetic markers as indicators of gastric cancer risk

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Helicobactor pylori

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Abstract

It has long been established that human susceptibility to infectious agents is at least partly under genetic control. Several observations from twin, adoptee, pedigree, and candidate gene studies point to host genetic factors as key determinants of this susceptibility1,2. The recent explosion in genetic knowledge, accelerated by the human genome project, is helping to unravel the molecular pathways that mediate genetic susceptibility to human diseases, including infections and cancer3–5. While genetic susceptibility may apply to the risk of acquisition of an infectious agent, it is becoming increasingly recognized that host genes also influence the pathophysiological response to infections, which ultimately determine the clinical outcome.

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References

  1. Hill AV. The genomics and genetics of human infectious disease susceptibility. Annu Rev Genomics Hum Genet. 2001; 2: 373–400.

    Article  PubMed  CAS  Google Scholar 

  2. Hill AV. The immunogenetics of human infectious diseases. Annu Rev Immunol. 1998; 16: 593–617.

    Article  PubMed  CAS  Google Scholar 

  3. Subramanian G, Adams MD, Venter JC, Broder S. Implications of the human genome for understanding human biology and medicine. J Am Med Assoc. 2001; 286: 2296–307.

    Article  CAS  Google Scholar 

  4. Subramanian G, Mural R, Hoffman SL, Venter JC, Broder S. Microbial disease in humans: a genomic perspective. Mol Diagn. 2001; 6: 243–52.

    PubMed  CAS  Google Scholar 

  5. Ponder BA. Cancer genetics. Nature. 2001; 411: 336–41.

    Article  PubMed  CAS  Google Scholar 

  6. Kuper H, Adami HO, Trichopoulos D. Infections as a major preventable cause of human cancer. J Intern Med. 2000; 248: 171–83.

    Article  PubMed  CAS  Google Scholar 

  7. Parsonnet J. Introduction. In: Parsonnet J, editor. Microbes and Malignancy. New York: Oxford University Press, 1999: 3–15.

    Google Scholar 

  8. Israel DA, Peek RM. Pathogenesis of Helicobacter pylori-induced gastric inflammation. Aliment Pharmacol Ther. 2001; 15: 1271–90.

    Article  PubMed  CAS  Google Scholar 

  9. Fridman WH, Tartour E. Cytokines and cell regulation. Mol Aspects Med. 1997; 18: 3–90.

    Article  PubMed  CAS  Google Scholar 

  10. Robert A, Olafsson AS, Lancaster C, Zhang WR. Interleukin-1 is cytoprotective, antisecretory, stimulates PGE2 synthesis by the stomach, and retards gastric emptying. Life Sci. 1991; 48: 123–34.

    Article  PubMed  CAS  Google Scholar 

  11. Wolfe MM, Nompleggi DJ. Cytokine inhibition of gastric acid secretion — a little goes a long way. Gastroenterology. 1992; 102: 2177–8.

    PubMed  CAS  Google Scholar 

  12. Beales IL, Calam J. Interleukin 1 beta and tumour necrosis factor alpha inhibit acid secretion in cultured rabbit parietal cells by multiple pathways. Gut. 1998; 42: 227–34.

    Article  PubMed  CAS  Google Scholar 

  13. McColl KE, El-Omar E, Gillen D. Helicobacter pylori gastritis and gastric physiology. Gastroenterol Clin N Am. 2000; 29: 687–703.

    Article  CAS  Google Scholar 

  14. Marshall BJ, Armstrong JA, McGechie DB, Glancy RJ. Attempt to fulfil Koch’s postulates for pyloric Campylobacter. Med J Aust. 1985; 142: 436–9.

    PubMed  CAS  Google Scholar 

  15. Morris A, Nicholson G. Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH. Am J Gastroenterol. 1987; 82: 192–9.

    PubMed  CAS  Google Scholar 

  16. Danon SJ, O’Rourke JL, Moss ND, Lee A. The importance of local acid production in the distribution of Helicobacter fells in the mouse stomach. Gastroenterology. 1995; 108: 1386–95.

    Article  PubMed  CAS  Google Scholar 

  17. Kuipers EJ, Uyterlinde AM, Pena AS et al. Increase of Helicobacter pylori-associated corpus gastritis during acid suppressive therapy: implications for long-term safety. Am J Gastroenterol. 1995; 90: 1401–6.

    PubMed  CAS  Google Scholar 

  18. Kuipers EJ, Lundell L, Klinkenberg-Knol EC et al. Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication. N Engl J Med. 1996; 334: 1018–22.

    Article  PubMed  CAS  Google Scholar 

  19. Kuipers EJ, Lee A, Klinkenberg-Knol EC, Meuwissen SG. Review article: The development of atrophic gastritis — Helicobacter pylori and the effects of acid suppressive therapy. Aliment Pharmacol Ther. 1995; 9: 331–40.

    Article  PubMed  CAS  Google Scholar 

  20. Hansson LE, Nyren O, Hsing AW et al. The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N Engl J Med. 1996; 335: 242–9.

    Article  PubMed  CAS  Google Scholar 

  21. El-Omar EM, Oien K, El Nujumi A et al. Helicobacter pylori infection and chronic gastric acid hyposecretion. Gastroenterology. 1997; 113: 15–24.

    Article  PubMed  CAS  Google Scholar 

  22. El-Omar EM, Penman ID, Ardill JE et al. Helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease. Gastroenterology. 1995; 109: 681–91.

    Article  PubMed  CAS  Google Scholar 

  23. Hogan DL, Rapier RC, Dreilinger A et al. Duodenal bicarbonate secretion: eradication of Helicobacter pylori and duodenal structure and function in humans. Gastroenterology. 1996; 110: 705–16.

    Article  PubMed  CAS  Google Scholar 

  24. Dinarello CA. Biologic basis for interleukin-1 in disease. Blood. 1996; 87: 2095–147.

    PubMed  CAS  Google Scholar 

  25. Graham DY, Yamaoka Y. Disease-specific Helicobacter pylori virulence factors: the unfulfilled promise. Helicobacter. 2000; 5 (Suppl. 1): S3–9.

    Article  PubMed  Google Scholar 

  26. Noach LA, Bosma NB, Jansen J et al. Mucosal tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8 production in patients with Helicobacter pylori infection. Scand J Gastroenterol. 1994; 29: 425–9.

    Article  PubMed  CAS  Google Scholar 

  27. Basso D, Scrigner M, Toma A et al. Helicobacter pylori infection enhances mucosal interleukin-1 beta, interleukin-6, and the soluble receptor of interleukin-2. Int J Clin Lab Res. 1996; 26: 207–10.

    Article  PubMed  CAS  Google Scholar 

  28. Jung HC, Kim JM, Song IS, Kim CY. Helicobacter pylori induces an array of pro-inflammatory cytokines in human gastric epithelial cells: quantification of mRNA for interleukin-8, -1 alpha/beta, granulocyte-macrophage colony-stimulating factor, monocyte chemoattractant protein-1 and tumour necrosis factor-alpha. J Gastroenterol Hepatol. 1997; 12: 473–80.

    Article  PubMed  CAS  Google Scholar 

  29. Wilkinson RJ, Patel P, Llewelyn M et al. Influence of polymorphism in the genes for the interleukin (IL)-1 receptor antagonist and IL-lbeta on tuberculosis. J Exp Med. 1999; 189: 1863–74.

    Article  PubMed  CAS  Google Scholar 

  30. Sciacca FL, Ferri C, Vandenbroeck K et al. Relevance of interleukin 1 receptor antagonist intron 2 polymorphism in Italian MS patients. Neurology. 1999; 52: 1896–8.

    Article  PubMed  CAS  Google Scholar 

  31. Engebretson SP, Lamster IB, Herrera-Abreu M et al. The influence of interleukin gene polymorphism on expression of interleukin-lbeta and tumor necrosis factor-alpha in periodontal tissue and gingival crevicular fluid. J Periodontol. 1999; 70: 567–73.

    Article  PubMed  CAS  Google Scholar 

  32. Bidwell J, Keen L, Gallagher G et al. Cytokine gene polymorphism in human disease: on-line databases, supplement 1. Genes Immun. 2001; 2: 61–70.

    Article  PubMed  CAS  Google Scholar 

  33. Hurme M, Santtila S. IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-lbeta genes. Eur J Immunol. 1998; 28: 2598–602.

    Article  PubMed  CAS  Google Scholar 

  34. Pociot F, Molvig J, Wogensen L, Worsaae H, Nerup J. A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro. Eur J Clin Invest. 1992; 22: 396–402.

    Article  PubMed  CAS  Google Scholar 

  35. Donn RP, Farhan AJ, Barrett JH et al. Absence of association between interleukin 1 alpha and oligoarticular juvenile chronic arthritis in UK patients. Rheumatology (Oxford). 1999; 38: 171–5.

    Article  CAS  Google Scholar 

  36. Danis VA, Millington M, Hyland VJ, Grennan D. Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism. Clin Exp Immunol. 1995; 99: 303–10.

    Article  PubMed  CAS  Google Scholar 

  37. Tountas NA, Casini-Raggi V, Yang H et al. Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis. Gastroenterology. 1999; 117: 806–13.

    Article  PubMed  CAS  Google Scholar 

  38. Andus T, Daig R, Vogl D et al. Imbalance of the interleukin 1 system in colonic mucosa — association with intestinal inflammation and interleukin 1 receptor antagonist [corrected] genotype 2. Gut. 1997; 41: 651–7.

    Article  PubMed  CAS  Google Scholar 

  39. Cork MJ, Crane AM, DuffGW. Genetic control of cytokines. Cytokine gene polymorphisms in alopecia areata. Dermatol Clin. 1996; 14: 671–8.

    Article  PubMed  CAS  Google Scholar 

  40. Perrier S, Coussediere C, Dubost JJ, Albuisson E, Sauvezie B. IL-1 receptor antagonist (IL-1RA) gene polymorphism in Sjögren’s syndrome and rheumatoid arthritis. Clin Immunol Immunopathol. 1998; 87: 309–13.

    Article  PubMed  CAS  Google Scholar 

  41. El-Omar EM, Carrington M, Chow WH et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature. 2000; 404: 398–402.

    Article  PubMed  CAS  Google Scholar 

  42. El-Omar EM, Chow WH, Gammon MD, Vaughan TL, Risch HA, Fraumeni JF Jr. Pro-inflammatory genotypes of IL-1 beta, TNF-alpha and IL-10 increase risk of distal gastric cancer but not of cardia or oesophageal adenocarcinoma. Gastroenterology. 2001; 120 (Suppl. 1): A86.

    Article  Google Scholar 

  43. Machado JC, Pharoah P, Sousa Set al. Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma. Gastroenterology. 2001; 121: 823–9.

    Article  PubMed  CAS  Google Scholar 

  44. Furuta T, El Omar EM, Xiao F et al. Interleukin theta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan. Gastroenterology. 2002; 123: 92–105.

    Article  PubMed  CAS  Google Scholar 

  45. Kuipers EJ. Review article: Exploring the link between Helicobacter pylori and gastric cancer. Aliment Pharmacol Ther. 1999; 13 (Suppl. 1): 3–11.

    Article  PubMed  Google Scholar 

  46. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process — First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res. 1992; 52: 6735–40.

    PubMed  CAS  Google Scholar 

  47. Mayne ST, Risch HA, Dubrow R et al. Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prey. 2001; 10: 1055–62.

    CAS  Google Scholar 

  48. Banerjee S, Hawksby C, Miller S et al. Effect of Helicobacter pylori and its eradication on gastric juice ascorbic acid. Gut. 1994; 35: 317–22.

    Article  PubMed  CAS  Google Scholar 

  49. Woodward M, Tunstall-Pedoe H, McColl K. Helicobacter pylori infection reduces systemic availability of dietary vitamin C. Eur J Gastroenterol Hepatol. 2001; 13: 233–7.

    Article  PubMed  CAS  Google Scholar 

  50. Kneller RW, You WC, Chang YS et al. Cigarette smoking and other risk factors for progression of precancerous stomach lesions. J Natl Cancer Inst. 1992; 84: 1261–66.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. E. Troost
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  2. G. L. Hold
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  3. M. Smith
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  4. W.-H. Chow
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  5. C. S. Rabkin
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  6. K. E. L. McColl
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  7. E. M. El-Omar
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Editor information

Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, L8N 3Z5, Hamilton, Ontario, Canada

    Richard H. Hunt (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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© 2003 Springer Science+Business Media Dordrecht

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Troost, E. et al. (2003). Role of interleukin-1 beta and other potential genetic markers as indicators of gastric cancer risk. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobactor pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-1763-2_22

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  • DOI: https://doi.org/10.1007/978-94-017-1763-2_22

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5778-5

  • Online ISBN: 978-94-017-1763-2

  • eBook Packages: Springer Book Archive

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