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Applications of NMR Spectroscopy and Imaging to the Study of Immobilised Cell Physiology

  • Chapter
Fundamentals of Cell Immobilisation Biotechnology

Part of the book series: Focus on Biotechnology ((FOBI,volume 8A))

Abstract

The use of NMR spectroscopy and imaging in biology and medicine has grown dramatically over the last decade. The popularity of these magnetic resonance methods stems directly from the fact that they are non-invasive and can provide extremely detailed information about the chemical environment of atomic nuclei. Dynamic metabolic phenomena can be studied in real time, without perturbing normal cellular function. The biggest limitation in using NMR to study living systems is that it is a relatively insensitive technique. For this reason, immobilisation methods are generally used to culture cells at high densities for NMR studies.

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  1. Department of Radiology, University of Pennsylvania, B6 Blockley Hall, Philadelphia, PA, 19104-6069, USA

    Anthony Mancuso & Jerry D. Glickson

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    Viktor Nedović

  2. Free University of Brussels, Brussels, Belgium

    Ronnie Willaert

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Mancuso, A., Glickson, J.D. (2004). Applications of NMR Spectroscopy and Imaging to the Study of Immobilised Cell Physiology. In: Nedović, V., Willaert, R. (eds) Fundamentals of Cell Immobilisation Biotechnology. Focus on Biotechnology, vol 8A. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-1638-3_23

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  • DOI: https://doi.org/10.1007/978-94-017-1638-3_23

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6534-6

  • Online ISBN: 978-94-017-1638-3

  • eBook Packages: Springer Book Archive

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