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Immobilised Cell Bioreactors

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Fundamentals of Cell Immobilisation Biotechnology

Part of the book series: Focus on Biotechnology ((FOBI,volume 8A))

Abstract

Over the last decades, immobilised cell systems were widely investigated and used in different fields of biotechnology such as pharmacy, biomedicine, food and environmental technologies Immobilised cell technology is successfully established at the industrial scale in wastewater treatment and production of biopharmaceuticals and fermented beverages. Cell immobilisation provides several advantages over the conventional free cell systems including higher cell concentrations, higher volumetric productivities, cell protection required for shear sensitive cells, and easy separation of cells and products. In addition, immobilised cell systems can be operated in continuous mode at higher dilution rates without the risk of cell washout. Especially attractive are the options for co-immobilisation of different cell types for the simultaneous implementation of consecutive reactions.

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Authors and Affiliations

  1. Department of Chemical Engineering, Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, PO Box 3503, 1120, Belgrade, Yugoslavia

    Bojana Obradovic & Branko Bugarski

  2. Department of Food Technology and Biochemistry, University of Belgrade, Nemanjina 6, PO Box 127, 11081, Belgrade-Zemun, Yugoslavia

    Viktor A. Nedović

  3. Department of Ultrastructure, Flanders Interuniversity Institute for Biotechnology, Vrije Universiteit Brussel, Pleinlaan 2, B-1050, Brussels, Belgium

    Ronnie G. Willaert

  4. Harvard — MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, E25-330, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA

    Gordana Vunjak-Novakovic

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  1. Bojana Obradovic
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  2. Viktor A. Nedović
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  3. Branko Bugarski
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  4. Ronnie G. Willaert
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  5. Gordana Vunjak-Novakovic
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  1. University of Belgrade, Belgrade, Serbia and Montenegro

    Viktor Nedović

  2. Free University of Brussels, Brussels, Belgium

    Ronnie Willaert

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Obradovic, B., Nedović, V.A., Bugarski, B., Willaert, R.G., Vunjak-Novakovic, G. (2004). Immobilised Cell Bioreactors. In: Nedović, V., Willaert, R. (eds) Fundamentals of Cell Immobilisation Biotechnology. Focus on Biotechnology, vol 8A. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-1638-3_22

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  • DOI: https://doi.org/10.1007/978-94-017-1638-3_22

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